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Discussions reflect a balance of curiosity and critical analysis, with posts referencing the sex and dose dependency of rapamycin's effects, its metabolic distinctness from dietary restriction, and concerns about behavioral side effects; the tone ranges from scientific curiosity to cautious skepticism, illustrating both interest and engagement in understanding its broader implications.
Most discussions acknowledge the findings, especially the dose and sex dependency of rapamycin's effects, showing moderate consensus.
Participants demonstrate a moderate interest, discussing both the potential and limitations of rapamycin for lifespan extension.
The exchanges include detailed comments on biological mechanisms and considerations, indicating engaged and thoughtful participation.
The conversations highlight the significance of these findings for future research, but some express skepticism about translating results to humans, indicating moderate perceived impact.
The longest documented lifespan extension by rapamycin was 26%; this was in mice. Unfortunately, there has been no study of rapamycin in the lifespan extension of humans and primates so far. https://t.co/CMTaLxuIZh
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Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction (2014) https://t.co/BYrjT8wfVs #ITP
@NathanielEDavid @LammingLab
Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction (2014) https://t.co/LZeW4lBh1x
The Interventions Testing Program funded by the National Institute on Aging investigates various compounds to prevent disease and extend lifespan in mice. This video explores key findings and principles from the ITP…
Senolytic drugs dasatinib and quercetin reduce cell senescence and inflammation in fat tissue, enhancing metabolic functions such as blood glucose regulation and lowering blood fats in old mice.
If you are a mouse, rapamycin can increase lifespan by 23% (males) to 26% (females) https://t.co/05toGQyGwO
RT @IchorGrad: 1) https://t.co/MRfVDErVyL 2) https://t.co/F3qTtBGl4G 3) https://t.co/6hOIiUyeYq 4) https://t.co/TS1tzdWphD 5) https://t.co/…
1) https://t.co/MRfVDErVyL 2) https://t.co/F3qTtBGl4G 3) https://t.co/6hOIiUyeYq 4) https://t.co/TS1tzdWphD 5) https://t.co/JvhTNb0YEw 6) https://t.co/F3qTtBGl4G 7) https://t.co/sq3GXije2P 8) https://t.co/sq3GXije2P 9) https://t.co/l4NcesiLEk 10) https://t.co/tZs5fscUVo
RT @drkohilathas: The longest documented lifespan extension by rapamycin was 26%; this was in mice. Unfortunately, there has been no study…
RT @drkohilathas: The longest documented lifespan extension by rapamycin was 26%; this was in mice. Unfortunately, there has been no study…
RT @drkohilathas: The longest documented lifespan extension by rapamycin was 26%; this was in mice. Unfortunately, there has been no study…
RT @drkohilathas: The longest documented lifespan extension by rapamycin was 26%; this was in mice. Unfortunately, there has been no study…
The longest documented lifespan extension by rapamycin was 26%; this was in mice. Unfortunately, there has been no study of rapamycin in the lifespan extension of humans and primates so far. https://t.co/CMTaLxuIZh
@NataliaMitin @MattYousefzadeh In general, females (flies and mice) showed greater lifespan extension in responses to rapamycin, when it used chronically. Mice results - > e.g. ITP Rich Miller et al. https://t.co/7h65UU9lQh
Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction. https://t.co/XtioM1Vm46
Ссылки: 1) https://t.co/YWgEIwj8oE 2) https://t.co/1GCbMvroED 4) https://t.co/pgVwKDxdg7 5) https://t.co/ajvt5l4PvQ
Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction (2014) https://t.co/BYrjT8wfVs #ITP
Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction (2014) https://t.co/LZeW4lBh1x
@NathanielEDavid @LammingLab
@shunyata2000 Rapamycin • Fighting elevated in highest-dose-group ➡️high proportion of mice removed ➡️removal of up-to 22% of cages • More serious fight wounds • ➡️aggressive behavior and/or poor wound healing? • "Data" : Mice removed for fighting treated as alive https://t.co/bMmj5nOoDU
Rapamycin • Fighting elevated in highest-dose-group ➡️high proportion of mice removed ➡️removal of up-to 22% of cages • More serious fight wounds • ➡️aggressive behavior and/or poor wound healing? • "Data" : Mice removed for fighting treated as alive https://t.co/bMmj5nOoDU
https://t.co/QyaGQ6wv38
@Blagosklonny Very poss true- higher doses correl w/ both glucose & LE ( tho’ in man we may mitigate w/ other rx & optim. schedules). https://t.co/BSG1fxRGmv Since LE in man is unproven, w/o lifespan studies we need better efficacy & risk surrogates. Eg-quantif. relation b/n trough & ID risk
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