This is why I'll ALWAYS discourage long term keto. To compensate being low on glucose and adapt to utilizing ketones, my body down regulated insulin production. Use it or lose it. Keto causes low β- and α-cell mass along with a whole host of other issues. https://t.co/GBjFVVjkqI
Long-term ketogenic diet causes glucose intolerance and reduced β- and α-cell mass but no weight loss in mice.
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Mar 2019 – Jul 2025Where it's discussed
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X / Twitter27 posts
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Facebook22 posts
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YouTube6 videos
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News4 articles
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Reddit2 posts
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AI synopsis
What people are saying
Several posts highlight concerns about the long-term health implications of keto diets, such as decreased insulin production and pancreatic cell mass, exemplified by comments like 'Keto causes low β- and α-cell mass' and calls for clarification on clinical evidence. The tone varies from cautious critique to supportive, with some posts questioning the validity of ketogenic foods marketed as 'healthy,' emphasizing a critical stance that underscores the scientific importance of the findings.
Most discussions acknowledge the findings or express concern, with some posts explicitly supporting the study's conclusions about negative long-term effects of keto diets on pancreatic function and metabolic health.
Posts demonstrate high curiosity, as users respond to the research with questions, critiques, and calls for expert opinions, showing they find the topic highly relevant.
Many participants delve into detailed analyses, referencing specific aspects like insulin, alpha- and beta-cell mass, and long-term health risks, indicating deep engagement.
While some posts imply the study could influence opinions or dietary choices, overall the perceived impact remains moderate due to skepticism and the request for further evidence.
Abstract in brief
- Longterm ketogenic diets in mice lead to glucose intolerance, reduced pancreatic cell mass, and signs of metabolic issues like dyslipidemia and hepatic steatosis, despite initial weight loss.
- The study found that after 22 weeks, mice on a longterm KD showed decreased insulin secretion, impaired glucose uptake, and an increase in smaller, less functional islets, indicating compromised pancreatic function.
- These findings suggest that, over time, high-fat low-carbohydrate KD may mimic features of metabolic syndrome and raise risks for type 2 diabetes, without promoting sustained weight loss.]
Top posts
Most liked on X and Blueskyケトジェニックダイエットの注意点について知っていますか?果物や穀物から得られる有益な食物繊維やポリフェノールの不足です!
De donde salio el sustento serio para llamar a un alimento "Keto"? .De los mismos creadores de alimentos "funcionales"?.En que momento una dieta que nació como ayuda en epilepsia se volvió sinónimo de postres para bajar de peso? https://t.co/XaFi2jWFn5
@AncestorAligned https://t.co/rzn1eTprOz
@MurseDarius @gatordadsteve @dr_ericberg @Pl4ntbased @MichaelMindrum @NutritionMadeS3 @realDaveFeldman You may also need to know that long term KD reduces beta cell function in mice and this may be one of the reasons for your blunted insulin response. https://t.co/kOKKRbyebB
@findinSilver @erreyedoc @DrNadolsky There are many studies on IF without other dietary intervention. Would be worth looking into. Long term #keto studies here- https://t.co/plJgeuFNLS https://t.co/HkZZLPm7hJ https://t.co/PsIdgRJ0SR
All mentions
Long-term Ketogenic Diet Effects on Glucose and Pancreatic Cells in Mice
Long-term ketogenic diets in mice lead to glucose intolerance, reduced pancreatic cell mass, and signs of metabolic issues like dyslipidemia and hepatic steatosis, despite initial weight loss. The study observed…
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Impact of Long-term Ketogenic Diets on Glucose Tolerance in Mice
Long-term ketogenic diets in mice lead to glucose intolerance, reduced pancreatic cell mass, and metabolic issues such as dyslipidemia and hepatic steatosis, despite initial weight loss. The study shows impaired insulin…
RT @somethings_awry: This is why I'll ALWAYS discourage long term keto. To compensate being low on glucose and adapt to utilizing ketones,…
This is why I'll ALWAYS discourage long term keto. To compensate being low on glucose and adapt to utilizing ketones, my body down regulated insulin production. Use it or lose it. Keto causes low β- and α-cell mass along with a whole host of other issues. https://t.co/GBjFVVjkqI
@MurseDarius @gatordadsteve @dr_ericberg @Pl4ntbased @MichaelMindrum @NutritionMadeS3 @realDaveFeldman You may also need to know that long term KD reduces beta cell function in mice and this may be one of the reasons for your blunted insulin response. https://t.co/kOKKRbyebB
@HannahDCox https://t.co/tm431Meiyl Or maybe there's actual research and overly simple answers like "carbs = bad" don't fix the issue in the long term.
@carnivore_jt @TempleDietitian https://t.co/crkBaua1lN
RT @tarou_ymd_: ケトジェニックダイエットの注意点について知っていますか?果物や穀物から得られる有益な食物繊維やポリフェノールの不足です!
RT @tarou_ymd_: ケトジェニックダイエットの注意点について知っていますか?果物や穀物から得られる有益な食物繊維やポリフェノールの不足です!
RT @tarou_ymd_: ケトジェニックダイエットの注意点について知っていますか?果物や穀物から得られる有益な食物繊維やポリフェノールの不足です!
RT @tarou_ymd_: ケトジェニックダイエットの注意点について知っていますか?果物や穀物から得られる有益な食物繊維やポリフェノールの不足です!
ケトジェニックダイエットの注意点について知っていますか?果物や穀物から得られる有益な食物繊維やポリフェノールの不足です!
@JohnCaseIII @MacroFour https://t.co/OKOP4GZnvi
RT @LondonoMd: De donde salio el sustento serio para llamar a un alimento "Keto"? .De los mismos creadores de alimentos "funcionales"?.En q…
De donde salio el sustento serio para llamar a un alimento "Keto"? .De los mismos creadores de alimentos "funcionales"?.En que momento una dieta que nació como ayuda en epilepsia se volvió sinónimo de postres para bajar de peso? https://t.co/XaFi2jWFn5
@AncestorAligned https://t.co/rzn1eTprOz
@MofoKang @UncreatdSkeptic @RedbananaTH @Matt_Dillahunty This indicates that long-term high-fat, low-carbohydrate KD lead to features that are also associated with the metabolic syndrome and an increased risk for type 2 diabetes in humans. https://t.co/zFwD6QlZSy
@findinSilver @erreyedoc @DrNadolsky There are many studies on IF without other dietary intervention. Would be worth looking into. Long term #keto studies here- https://t.co/plJgeuFNLS https://t.co/HkZZLPm7hJ https://t.co/PsIdgRJ0SR
@happyselvan @themanalivora @EduMinOfIndia https://t.co/1QLI4YEyTm
@DiscoStew66 Here : https://t.co/sQ0G2kAjYx And here : https://t.co/GRvkTc2kwj
@KetoHiking @Poffertjee @RektMoranis It can still cause problems for healthy livers. And monitoring and when and if necessary: adjusting is critical in young, still growing patients with complicated or weekend health conditions to begin with. https://t.co/2KFsWI9NgK
@Dr__Guess OK, that is clarifying. That theory begs clinical long-term evidence :). Any? Those adaptations should be quite dramatic to offset the reduction of 100-200 g carbs/d, don’t you think? You are probably thinking of pre-clinical evidence? https://t.co/YZDYvc2JeB
@kevinnbass From animal studies, there seem to be chronic problems rather than benefits. Mice on long-term ketogenic diets develop diabetes, dyslipidemia, and hepatic steatosis over the course of 5-6 months: https://t.co/6shBl63n7g Ketogenic diets only mimic the health benefits of fasting.
RT @PreKureOfficial: In this ketogenic diet mouse study, alpha-cell mass decreased even more significantly than beta-cell mass, consistent…
In this ketogenic diet mouse study, alpha-cell mass decreased even more significantly than beta-cell mass, consistent with a lowered glucagon level. https://t.co/fEG8kOCcfR
RT @texas_nancy: Would like to see a response from some of the keto experts on this study, https://t.co/GfLgsSArxq
@FatEmperor Have you looked at this study? As a committed keto/low-carb advocate, I am disturbed. https://t.co/GfLgsSArxq
Would like to see a response from some of the keto experts on this study, https://t.co/GfLgsSArxq
Long-term #ketogenic diet causes glucose intolerance, THE OTHER TERM FOR WHAT I CALL HUMAN FOOD INTOLERANCE #keto #ketogenicdiet #lchf #potatodiet #zerofat #nofat #weightloss #keto Read here: https://t.co/tYLkiWT4yJ https://t.co/BSQkTzwZ8C