Psychol Bull May 2014 PMID 24417575

From stress to inflammation and major depressive disorder: a social signal transduction theory of depression.

George M Slavich, Michael R Irwin

Mentions

94
Peak: 12 in Dec 2025
across 6 sources since Dec 2018

Extended reach

6,488
potential audience

Total likes

23

Video views

2,436

Mentions per month

Dec 2018 – Dec 2025

Where it's discussed

  • Instagram45 posts
  • Blogs24 articles
  • Facebook16 posts
  • Reddit5 posts
  • X / Twitter2 posts
  • YouTube2 videos

AI synopsis

What people are saying

Several posts highlight the role of social stress and inflammation, such as references to the longstanding link between social adversity and depression, while others discuss the biological mechanisms involved. The tone varies from curiosity to cautious optimism, emphasizing the importance of this work for advancing mental health research.

AgreementModerate agreement

Most discussions acknowledge the connection between social stress, inflammation, and depression, indicating general agreement with the research's framework.

InterestModerate interest

Participants show moderate curiosity, referencing past studies and emphasizing the relevance of social stressors in mental health.

EngagementModerate engagement

The posts include some detailed comments and reflections on the mechanisms involved, demonstrating a basic but thoughtful level of engagement.

ImpactModerate impact

The discussions suggest that this research may influence understanding and future treatment approaches, as seen in mentions of its significance for mental health and potential interventions.

Abstract in brief

  • Social stressors, especially interpersonal rejection, are major risk factors for depression, and this theory explains how social adversity activates biological processes leading to depression.
  • The theory suggests that social threats increase inflammation via immune system components called proinflammatory cytokines, which can cause depressive behaviors like sadness, fatigue, and social withdrawal.
  • This inflammation response, evolved for physical danger, can be triggered by modern social stress, linking depression to other health issues like heart disease, arthritis, and obesity, and highlighting new avenues for prevention and treatment by targeting inflammation.]

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UCLA Stress Lab
@UCLAStressLab · X

RT @myuuko: うつ病の炎症仮説にかんする2014年のレビュー論文。今はもううつ病は炎症反応あるよねーってことで落ち着いてるのかな。/ From stress to inflammation and major depressive disorder: A social…

Oct 24, 2022 · 4 shares · 3,070 followers View post →
Mind Body Health Studies
@zychosomatic · X

RT @myuuko: うつ病の炎症仮説にかんする2014年のレビュー論文。今はもううつ病は炎症反応あるよねーってことで落ち着いてるのかな。/ From stress to inflammation and major depressive disorder: A social…

Oct 24, 2022 · 4 shares · 66 followers View post →

All mentions

Mind Body Health Studies
@zychosomatic · X

RT @myuuko: うつ病の炎症仮説にかんする2014年のレビュー論文。今はもううつ病は炎症反応あるよねーってことで落ち着いてるのかな。/ From stress to inflammation and major depressive disorder: A social…

Oct 24, 2022 · 4 shares · 66 followers View post →
UCLA Stress Lab
@UCLAStressLab · X

RT @myuuko: うつ病の炎症仮説にかんする2014年のレビュー論文。今はもううつ病は炎症反応あるよねーってことで落ち着いてるのかな。/ From stress to inflammation and major depressive disorder: A social…

Oct 24, 2022 · 4 shares · 3,070 followers View post →
A saúde nos tempos da peste do século XXI
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Mar 25, 2023 View →
#Neurociencias: El cerebro y su relación con la música. La relación ...
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DOI: 10.1037/a0035302. Miller, A. H., & Raison, C. L. (2016). Nature Reviews Immunology, 16(1), 22–34. DOI: 10.1038/nri.2016.5. more. December ...

Mar 4, 2023 View →
Interpersonal Life Stress and Inflammatory Reactivity as Prospective ...
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doi.org/10.1037/a0035302. Slavich, G. M., O'Donovan, A., Epel, E. S., & Kemeny, M. E. (2010). Black sheep get the blues: a psychobiological ...

Feb 28, 2023 View →
Neural and peripheral markers of reward during positive social ...
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140. (2014) 774–815, https://doi.org/10.1037/a0035302. [11] J. Vanhalst, K. Luyckx, R.H.J. Scholte, R.C.M.E. Engels, L. Goossens, Low self ...

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Psychological Bulletin, 140(3), 774. https://doi.org/10.1037/a0035302. Slavich, G. M., O'Donovan, A., Epel, E. S., & Kemeny ...

Jun 9, 2022 View →
Forgiveness, rumination, and depression in the United States and ...
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https://doi.org/10.1037/a0035302. Slavich, G. M., & Sacher, J. (2019). Stress, sex hormones, inflammation, and major depressive disorder ...

Apr 27, 2022 View →
Operacja kręgosłupa L5-S1. Wstawiony implant i śruby z powodu ...
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... . Psychological Bulletin, 140(3), 774–815. https://doi.org/10.1037/a0035302 · May be an image of phone · Adriana Strześniewska and 8 others ·

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Już w pełni oficjalnie - od listopada dołącza do mnie Artur Gruchała ...
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... , 140(3), 774–815. https://doi.org/10.1037/a0035302 · May be an image of phone · Adriana Strześniewska and 8 others ·

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... . Psychological Bulletin, 140(3), 774–815. https://doi.org/10.1037/a0035302 · May be an image of phone. Adriana Strześniewska and 8 others ·

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... . Psychological Bulletin, 140(3), 774–815. https://doi.org/10.1037/a0035302 · May be an image of phone. Adriana Strześniewska and 8 others ·

Feb 5, 2021 View →
Interpersonal life stress, inflammation, and depression in ...
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1037/a0035302. Slavich, G. M., Monroe, S. M., & Gotlib, I. H. ... org/10.1037/0022‐3514.54.6.1063. Yamakawa, K., Matsunaga, M., Isowa ...

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Stress and Health in Nursing Students: The Nurse Engagement and ...
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doi:10.1037/a0035302. Slavich, G. M., & Shields, G. S. (2018). Assessing lifetime stress exposure using the Stress and. Adversity Inventory ...

Oct 7, 2019 View →
Sex-specific association between prenatal life stress exposure and ...
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https://doi.org/10.1037/a0035302. Sutherland, S., Brunwasser, S.M., 2018. Sex differences in vulnerability to prenatal stress: a review of ...

Dec 11, 2018 View →