Neurosci Biobehav Rev March 2014 PMID 24456942

Genetics of borderline personality disorder: systematic review and proposal of an integrative model.

Ali Amad, Nicolas Ramoz, Pierre Thomas, Renaud Jardri, Philip Gorwood

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Mentions

12
Peak: 1 in May 2020
across 3 sources since May 2020

Extended reach

364,863
potential audience

Total likes

10,640

Video views

327,194

Mentions per month

May 2020 – Oct 2024

Where it's discussed

  • X / Twitter5 posts
  • YouTube4 videos
  • News3 articles

AI synopsis

What people are saying

Discussions demonstrate a strong curiosity about the genetic underpinnings of BPD, with comments emphasizing the 40% heritability and debates about the role of gene-environment interactions, showing that readers are critically engaging with the research and contemplating its broader implications.

AgreementModerate agreement

Most discussions acknowledge the importance of genetics in BPD, citing the roughly 40% heritability and emphasizing biological factors as key contributors.

InterestHigh interest

There is a high interest in the topic, with participants engaging in discussions about gene-environment interactions and the implications of the findings.

EngagementHigh engagement

Posts are detailed, referencing specific aspects of the study like heritability estimates and the distinction between vulnerability and causal genes, indicating deep engagement.

ImpactModerate impact

While the conversations highlight the significance of genetic research in understanding BPD, some express cautious optimism rather than revolutionary change, suggesting moderate perceived impact.

Abstract in brief

  • The systematic review highlights that borderline personality disorder (BPD) has a strong genetic component, with studies estimating about 40% of heritability, mainly supported by familial and twin research.
  • Despite some evidence for gene-environment interactions, direct association studies have been limited and show no consistent links with common genes like the serotonin transporter, TPH1, or 5-HT1B receptor.
  • The authors suggest shifting from focusing solely on vulnerability genes to considering plasticity genes, which influence how environmental factors affect the development of BPD, accounting for the high heritability but inconsistent genetic findings.]

Top posts

Most liked on X and Bluesky
Cristy Kawaoka
@CKawaoka · X

@MKTetra @Theholisticpsyc Although I agree, the current thinking in medicine is that there is a large genetic component - a "super sensitivity" to interpersonal dynamics: https://t.co/ukbPb52xDo

Nov 8, 2022 · 5 likes · 64 followers View post →
Anne Leblanc
@annebealeblanc · X

Esquizofrenia sendo hereditária: https://t.co/ioi7yesrhn. Borderline: https://t.co/TAYiTbZbd7 A lista continua, só TDI que é inconclusivo os estudos

Feb 3, 2024 · 4 likes · 3,674 followers View post →
Dr Tracy Westerman AM
@TracyWesterman · X

@autisticdoc @CowsgomooGW2 @BlackshepSusan @emmarattenbury_ I did not say genes ‘cause’ abuse. The nature/nurture interaction is in relation to “nurture” (abuse) which is linked to higher likelihood of PTSD&BPD.Genetic influence is about incr RISK/vulnerability. Not CAUSAL. Risk v cause is v different Some papers https://t.co/STIREnXDzm

Jan 27, 2022 · 3 likes · 30,444 followers View post →
S. Rozenblatt, Ph.D.
@nyneuropsych · X

@AllenFrancesMD About 40% of BPD is due to heritability. This leaves about 60% as being due to environmental or other causes, but we cannot overlook biology as a primary factor. https://t.co/RRvoVbz7hD

Dec 15, 2023 · 2 likes · 2,586 followers View post →

All mentions

Anne Leblanc
@annebealeblanc · X

Esquizofrenia sendo hereditária: https://t.co/ioi7yesrhn. Borderline: https://t.co/TAYiTbZbd7 A lista continua, só TDI que é inconclusivo os estudos

Feb 3, 2024 · 4 likes · 3,674 followers View post →
S. Rozenblatt, Ph.D.
@nyneuropsych · X

@AllenFrancesMD About 40% of BPD is due to heritability. This leaves about 60% as being due to environmental or other causes, but we cannot overlook biology as a primary factor. https://t.co/RRvoVbz7hD

Dec 15, 2023 · 2 likes · 2,586 followers View post →
Carlos
@clario17 · X

@vioverdu Sí, sí hay. https://t.co/JF4AApJCQu

Mar 16, 2023 · 2 likes · 902 followers View post →
Cristy Kawaoka
@CKawaoka · X

@MKTetra @Theholisticpsyc Although I agree, the current thinking in medicine is that there is a large genetic component - a "super sensitivity" to interpersonal dynamics: https://t.co/ukbPb52xDo

Nov 8, 2022 · 5 likes · 64 followers View post →
Dr Tracy Westerman AM
@TracyWesterman · X

@autisticdoc @CowsgomooGW2 @BlackshepSusan @emmarattenbury_ I did not say genes ‘cause’ abuse. The nature/nurture interaction is in relation to “nurture” (abuse) which is linked to higher likelihood of PTSD&BPD.Genetic influence is about incr RISK/vulnerability. Not CAUSAL. Risk v cause is v different Some papers https://t.co/STIREnXDzm

Jan 27, 2022 · 3 likes · 30,444 followers View post →