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J Neurochem May 2014 PMID 24460956

The oxidized form of vitamin C, dehydroascorbic acid, regulates neuronal energy metabolism.

Pedro Cisternas, Carmen Silva-Alvarez, Fernando Martínez, Emilio Fernandez, Luciano Ferrada, Karina Oyarce, Katterine Salazar, Juan P Bolaños, Francisco Nualart

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Mentions

7
Peak: 2 in Sep 2024
across 3 sources since Oct 2022

Extended reach

3,473
potential audience

Total likes

10

Video views

108

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Oct 2022 – Sep 2024

Where it's discussed

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AI synopsis

What people are saying

Discussions reflect a balanced interest, with posts noting how DHA influences neuronal metabolism and oxidative stress, using terms like 'regulates,' 'promotes,' and 'boosts.' Some posts highlight its potential impact on disease understanding, showing a thoughtful engagement with the article's implications.

AgreementModerate agreement

Most discussions acknowledge the importance of the research, with several posts expressing support or highlighting its significance for understanding neuronal energy mechanisms.

InterestModerate interest

The posts demonstrate moderate curiosity, mentioning elements like the role of DHA in antioxidant defenses and neuronal metabolism, showing a genuine but cautious interest.

EngagementModerate engagement

Many discussions reference specific biological processes such as glutathione levels, glucose oxidation, and the pentose phosphate pathway, indicating a reasonable depth of engagement.

ImpactModerate impact

Commenters suggest that these findings could influence future research or treatments related to oxidative stress and neuronal health, reflecting moderate perceived impact.

Abstract in brief

  • The study shows that rat brain neurons take up both ascorbic acid (AA) and its oxidized form, dehydroascorbic acid (DHA), with intracellular AA rapidly converting to DHA, which then impacts neuronal energy metabolism.
  • DHA causes a temporary decrease in glutathione levels but promotes increased glucose oxidation via the pentose phosphate pathway (PPP) by activating glucose-6-phosphate dehydrogenase, enhancing antioxidant defenses.
  • Additionally, DHA boosts lactate uptake by neurons in a dose- and time-dependent manner, suggesting it plays a key role in modulating neuronal energy use and protecting cells against oxidative stress.]
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Lee Stevenson
@bashuser · X

https://t.co/Jvf0htsYwn

Oct 29, 2022 · 1 like · 1,683 followers View post →
Lee Stevenson
@bashuser · X

The oxidized form of vitamin C, dehydroascorbic acid, regulates neuronal energy metabolism https://t.co/Jvf0htsqGP

Jan 29, 2024 · 1,683 followers View post →

All mentions

Lee Stevenson
@bashuser · X

The oxidized form of vitamin C, dehydroascorbic acid, regulates neuronal energy metabolism https://t.co/Jvf0htsqGP

Jan 29, 2024 · 1,683 followers View post →
Lee Stevenson
@bashuser · X

https://t.co/Jvf0htsYwn

Oct 29, 2022 · 1 like · 1,683 followers View post →