Nature March 2014 PMID 24463515

Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European.

Iñigo Olalde, Morten E Allentoft, Federico Sánchez-Quinto, Gabriel Santpere, Charleston W K Chiang, Michael DeGiorgio, Javier Prado-Martinez, Juan Antonio Rodríguez, Simon Rasmussen, Javier Quilez, Oscar Ramírez, Urko M Marigorta, Marcos Fernández-Callejo, María Encina Prada, Julio Manuel Vidal Encinas

Mentions

165
Peak: 3 in Mar 2025
across 6 sources since Apr 2023

Extended reach

527,919
potential audience

Total likes

23,664

Video views

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Where it's discussed

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  • YouTube6 videos
  • Reddit2 posts

AI synopsis

What people are saying

The discussions reflect a balanced interest; for example, posts referencing the rare Y-DNA haplogroup C highlight curiosity about genetic lineage, while mentions of pigmentation alleles show engagement with evolutionary implications. The tone varies from scientific references to casual skepticism, illustrating both curiosity and critical thinking, which contributes to a consensus that the study has meaningful yet interpretive significance.

AgreementModerate agreement

Many discussions acknowledge the significance of the study, with some expressing skepticism about interpretations, leading to a generally positive but nuanced consensus.

InterestModerate interest

Participants demonstrate moderate curiosity, mentioning specific details like Y-DNA haplogroups and pigmentation alleles, indicating engagement with scientific content.

EngagementModerate engagement

Several posts delve into details such as the rarity of certain genetic markers and their implications, showing active involvement and analysis.

ImpactModerate impact

The discussions suggest that the study's findings are considered relevant to understanding European prehistoric genetics and human evolution, reflecting a moderate perceived impact.

Abstract in brief

  • Ancient genomic analysis from a 7,000-year-old Mesolithic skeleton in Spain reveals insights into the origins of European farmers and their demographic impact.
  • The transition to agriculture during the Neolithic likely initiated genetic changes linked to immunity and diet, but data from earlier hunter-gatherers has been limited.
  • Findings indicate that the La Braña individual possessed ancestral alleles for skin pigmentation, implying that lighter skin was not common in Mesolithic Europe, and also carried adaptive variants suggesting early resistance to pathogens.

Top posts

Most liked on X and Bluesky
155 AUF1
@LiberPharos · X

@Nain_Portekoi "source" qui n'a pas lu l'article Iñigo Olalde et al., Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European. Nature 2014. [doi:10.1038/nature12960] [paywalled] "La Braña 1 carried the very rare Y-DNA haplogroup C (possibly C6-V20)" https://t.co/njXvtBIlVY

Mar 24, 2025 · 5 likes · 201 followers View post →
Viajantestoria2
@Viajantestoria2 · X

Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European: https://t.co/YMLmU41mVJ Single carcass of Mammuthus primigenius with lithic artifacts in the Upper Pleistocene of northern Italy: https://t.co/nxtnKa14sV

Jan 18, 2025 · 2 likes · 6,633 followers View post →
155 AUF1
@LiberPharos · X

@3lfares @RadioGenoa ye... but no! La Braña 1 carried the very rare Y-DNA haplogroup C (possibly C6-V20). DOI: 10.1038/nature12960 [paywalled] A dark-skinned Kazakh, why not, an african, NO! https://t.co/09zbNuoQWb

Mar 24, 2025 · 1 like · 201 followers View post →
DrSponz
@SponzDr · X

@kinshipactivist @smlmkl Ei arvailua vaan tunnetusti ihon väriin vaikuttavien geenien analyysiä WHG-löydöksistä. Esim. Naturen artikkelissa vuodelta 2014. https://t.co/XqeiZhEVxu

Nov 10, 2023 · 1 like · 102 followers View post →
Libre pensador
@Librepensador73 · X

4 Nina G. Jablonski (2004). The Evolution of Human Skin and Skin Color. Annual Review of Anthropology, 33:585–623. Olalde et al. (2014). Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European. Nature, 507(7491), 225–228.

Jul 27, 2025 · 2,133 followers View post →
Biswajit
@parresianz · X

@S1L3NT_WARR10R @yajnadevam See "Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European" by Ofalde et al. https://t.co/lJ8fYC9qK6

Apr 8, 2023 · 574 followers View post →

All mentions

The Genetic Basis of Blue Eye Color in Humans

This video explores the genetic factors behind blue eye color in humans, primarily focusing on a mutation in the HERC2 gene that inhibits OCA2 expression. Through research on a large Danish family, key SNPs associated…

Martina Mencucci · Apr 24, 2025 1,829 views
Libre pensador
@Librepensador73 · X

4 Nina G. Jablonski (2004). The Evolution of Human Skin and Skin Color. Annual Review of Anthropology, 33:585–623. Olalde et al. (2014). Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European. Nature, 507(7491), 225–228.

Jul 27, 2025 · 2,133 followers View post →
155 AUF1
@LiberPharos · X

@3lfares @RadioGenoa ye... but no! La Braña 1 carried the very rare Y-DNA haplogroup C (possibly C6-V20). DOI: 10.1038/nature12960 [paywalled] A dark-skinned Kazakh, why not, an african, NO! https://t.co/09zbNuoQWb

Mar 24, 2025 · 1 like · 201 followers View post →
155 AUF1
@LiberPharos · X

@Nain_Portekoi "source" qui n'a pas lu l'article Iñigo Olalde et al., Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European. Nature 2014. [doi:10.1038/nature12960] [paywalled] "La Braña 1 carried the very rare Y-DNA haplogroup C (possibly C6-V20)" https://t.co/njXvtBIlVY

Mar 24, 2025 · 5 likes · 201 followers View post →
Viajantestoria2
@Viajantestoria2 · X

Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European: https://t.co/YMLmU41mVJ Single carcass of Mammuthus primigenius with lithic artifacts in the Upper Pleistocene of northern Italy: https://t.co/nxtnKa14sV

Jan 18, 2025 · 2 likes · 6,633 followers View post →
Zephyr LópezCervilla
@zeephyyr · X

@GeorgePingas @DVoorkamp @SallyMayweather Those aren’t Rebecca Morelle's opinions: https://t.co/HpxsmBI2fi Olalde I, Allentoft M, Sánchez-Quinto F et al. “Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European.” Nature 507, 225–228 (2014) https://t.co/a5yCcNJddf https://t.co/vnE6IGs3AR https://t.co/i4v6rpCxvN

Nov 13, 2023 · 167 followers View post →
DrSponz
@SponzDr · X

@kinshipactivist @smlmkl Ei arvailua vaan tunnetusti ihon väriin vaikuttavien geenien analyysiä WHG-löydöksistä. Esim. Naturen artikkelissa vuodelta 2014. https://t.co/XqeiZhEVxu

Nov 10, 2023 · 1 like · 102 followers View post →
Biswajit
@parresianz · X

@S1L3NT_WARR10R @yajnadevam See "Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European" by Ofalde et al. https://t.co/lJ8fYC9qK6

Apr 8, 2023 · 574 followers View post →