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J Physiol April 2014 PMID 24492839

Vitamin C and E supplementation hampers cellular adaptation to endurance training in humans: a double-blind, randomised, controlled trial.

Gøran Paulsen, Kristoffer T Cumming, Geir Holden, Jostein Hallén, Bent Ronny Rønnestad, Ole Sveen, Arne Skaug, Ingvild Paur, Nasser E Bastani, Hege Nymo Østgaard, Charlotte Buer, Magnus Midttun, Fredrik Freuchen, Havard Wiig, Elisabeth Tallaksen Ulseth

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Mentions

102
Peak: 4 in May 2024
across 7 sources since Mar 2023

Extended reach

25,677
potential audience

Total likes

71

Video views

3,471

Mentions per month

Mar 2023 – May 2025

Where it's discussed

  • Facebook51 posts
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  • YouTube2 videos
  • Bluesky1 posts

AI synopsis

What people are saying

The discussions reveal a recognition that antioxidant supplements could interfere with cellular adaptation processes, exemplified by phrases such as 'may reduce the positive effects of our training' and mentions of mitochondrial biogenesis. The tone balances curiosity and caution, emphasizing the potential need to rethink routine antioxidant supplementation during endurance training.

AgreementModerate agreement

Most discussions acknowledge the study's findings that vitamin C and E supplements may hinder cellular adaptations during endurance training, indicating moderate support.

InterestModerate interest

Comments reflect a reasonable level of curiosity about the implications for supplement use and training outcomes.

EngagementModerate engagement

Postings include references to cellular mechanisms like mitochondrial biogenesis and practical fitness effects, showing moderate depth of engagement.

ImpactModerate impact

The exchanges suggest that the study influences opinions about supplement benefits, prompting reconsideration of antioxidant use during training.

Abstract in brief

  • This study investigated how daily supplementation of vitamin C and E affects endurance training adaptations in young adults and found that these vitamins do not improve performance but may interfere with some cellular markers of mitochondrial growth.
  • Despite similar gains in VO2 max and shuttle run performance between those taking vitamins and the placebo, the vitamin group showed less increase in mitochondrial-related markers like COX4 and PGC-1α, suggesting that antioxidants might hinder muscle cellular adaptations.
  • Overall, while vitamin C and E supplementation did not prevent improvements in physical performance, it appeared to blunt some of the muscle's biological responses to endurance training, raising questions about the benefits of antioxidant supplements during such training.
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Top posts

Most liked on X and Bluesky
#i
@IgnaBroomr · X

La ingesta habitual de #antioxidantes (Vit C y E) atenúa la activación de la biogénesis mitocondrial en respuesta al entrenamiento de resistencia, e incluso puede disminuir las ganancias de fuerza tras 10 semanas de entrenamiento https://t.co/xiLc3TxyGj

May 2, 2024 · 15 likes · 4 shares · 9,806 followers View post →
Harm Wiegers
@harmwiegers.bsky.social · Bluesky

Vitamins/anti-oxidants help our body recover. But this paper found that supplementing may reduce the positive effects of our training. This was new to me. Vitamin-rich foods are healthy, but vitamin C/E pills may not always be constructive? doi: 10.1113/jphysiol.2013.267419

Mar 1, 2025 · 2 likes View post →
taka_hirai
@stac_hirai_sub · X

Vitamin C and E supplementation hampers cellular adaptation to endurance training in humans: a double-blind, random… https://t.co/rwLav41AiZ

Aug 27, 2024 · 7,887 followers View post →
Jenaro Sport
@Jenaro_Sport · X

RT @IgnaBroomr: La ingesta habitual de #antioxidantes (Vit C y E) atenúa la activación de la biogénesis mitocondrial en respuesta al entren…

May 3, 2024 · 4 shares · 3,890 followers View post →
Dr Daniel Valencia Torres
@Doc_Valencia · X

RT @IgnaBroomr: La ingesta habitual de #antioxidantes (Vit C y E) atenúa la activación de la biogénesis mitocondrial en respuesta al entren…

May 3, 2024 · 4 shares · 566 followers View post →
Wigberto Marciaga Osorio
@WigbertoMar · X

RT @IgnaBroomr: La ingesta habitual de #antioxidantes (Vit C y E) atenúa la activación de la biogénesis mitocondrial en respuesta al entren…

May 2, 2024 · 4 shares · 26 followers View post →

All mentions

Harm Wiegers
@harmwiegers.bsky.social · Bluesky

Vitamins/anti-oxidants help our body recover. But this paper found that supplementing may reduce the positive effects of our training. This was new to me. Vitamin-rich foods are healthy, but vitamin C/E pills may not always be constructive? doi: 10.1113/jphysiol.2013.267419

Mar 1, 2025 · 2 likes View post →
taka_hirai
@stac_hirai_sub · X

Vitamin C and E supplementation hampers cellular adaptation to endurance training in humans: a double-blind, random… https://t.co/rwLav41AiZ

Aug 27, 2024 · 7,887 followers View post →
Jenaro Sport
@Jenaro_Sport · X

RT @IgnaBroomr: La ingesta habitual de #antioxidantes (Vit C y E) atenúa la activación de la biogénesis mitocondrial en respuesta al entren…

May 3, 2024 · 4 shares · 3,890 followers View post →
Dr Daniel Valencia Torres
@Doc_Valencia · X

RT @IgnaBroomr: La ingesta habitual de #antioxidantes (Vit C y E) atenúa la activación de la biogénesis mitocondrial en respuesta al entren…

May 3, 2024 · 4 shares · 566 followers View post →
Wigberto Marciaga Osorio
@WigbertoMar · X

RT @IgnaBroomr: La ingesta habitual de #antioxidantes (Vit C y E) atenúa la activación de la biogénesis mitocondrial en respuesta al entren…

May 2, 2024 · 4 shares · 26 followers View post →
#i
@IgnaBroomr · X

La ingesta habitual de #antioxidantes (Vit C y E) atenúa la activación de la biogénesis mitocondrial en respuesta al entrenamiento de resistencia, e incluso puede disminuir las ganancias de fuerza tras 10 semanas de entrenamiento https://t.co/xiLc3TxyGj

May 2, 2024 · 15 likes · 4 shares · 9,806 followers View post →