Stem Cell Reports January 2014 PMID 24511467

Breast cancer stem cells transition between epithelial and mesenchymal states reflective of their normal counterparts.

Suling Liu, Yang Cong, Dong Wang, Yu Sun, Lu Deng, Yajing Liu, Rachel Martin-Trevino, Li Shang, Sean P McDermott, Melissa D Landis, Suhyung Hong, April Adams, Rosemarie D'Angelo, Christophe Ginestier, Emmanuelle Charafe-Jauffret

Mentions

24
Peak: 6 in Jul 2023
across 4 sources since Dec 2022

Extended reach

212,633
potential audience

Total likes

16

Video views

209

Mentions per month

Dec 2022 – Nov 2023

Where it's discussed

  • News10 articles
  • X / Twitter6 posts
  • YouTube5 videos
  • Blogs3 articles

AI synopsis

What people are saying

The discussions reflect a balanced interest in the article's focus on cell state transitions, with phrases like 'important step forward' and 'potential for new therapies' suggesting recognition of its significance. The tone indicates genuine curiosity and acknowledgment of how understanding cellular plasticity could influence cancer treatment strategies.

AgreementModerate agreement

Most discussions acknowledge the significance of the research findings, with some emphasizing the importance of cell plasticity in cancer progression.

InterestModerate interest

People show moderate interest, noting the fascinating nature of cells transitioning states and the potential implications for treatment.

EngagementModerate engagement

The conversations include references to the broader context of breast cancer research and cellular behavior, indicating a moderate depth of engagement.

ImpactModerate impact

Participants generally perceive the research as impactful, highlighting its relevance to understanding metastasis and resistance in breast cancer.

Abstract in brief

  • Previous studies suggest breast cancer stem cells (BCSCs) are involved in metastasis, resistant to treatment, and contribute to cancer relapse.
  • This research identifies two distinct states of BCSCs: mesenchymal-like (quiescent, found at the tumor's invasive edge) and epithelial-like (proliferative, located more centrally).
  • Both BCSC types share similar gene-expression profiles across various breast cancer subtypes, indicating their plasticity enables them to switch states, which may aid in tissue invasion and spread of cancer.

Top posts

Most liked on X and Bluesky
Cell Press
@CellPressNews · X

Editor’s top pick from the last decade of @stemcellreports: Breast cancer stem cells transition between epithelial and mesenchymal states reflective of their normal counterparts @ISSCR @martinperaJAX @WichaLab https://t.co/qpjdrt0Hsy https://t.co/vQj89w8uxl

Jul 9, 2023 · 13 likes · 5 shares · 161,139 followers View post →
Dr. Shashank Joshi
@AskDrShashank · X

RT @CellPressNews: Editor’s top pick from the last decade of @stemcellreports: Breast cancer stem cells transition between epithelial and…

Jul 9, 2023 · 5 shares · 32,519 followers View post →
Norio Nakatsuji
@norionakatsuji · X

RT @CellPressNews: Editor’s top pick from the last decade of @stemcellreports: Breast cancer stem cells transition between epithelial and…

Jul 10, 2023 · 5 shares · 15,695 followers View post →
Martin Pera
@martinperaJAX · X

RT @CellPressNews: Editor’s top pick from the last decade of @stemcellreports: Breast cancer stem cells transition between epithelial and…

Jul 10, 2023 · 5 shares · 2,380 followers View post →
Jaroslav Novotný
@novotnyjarosl · X

RT @CellPressNews: Editor’s top pick from the last decade of @stemcellreports: Breast cancer stem cells transition between epithelial and…

Jul 9, 2023 · 5 shares · 604 followers View post →
VITENDER KUMAR
@VITENDERKUMAR2 · X

RT @CellPressNews: Editor’s top pick from the last decade of @stemcellreports: Breast cancer stem cells transition between epithelial and…

Jul 9, 2023 · 5 shares · 29 followers View post →

All mentions

Norio Nakatsuji
@norionakatsuji · X

RT @CellPressNews: Editor’s top pick from the last decade of @stemcellreports: Breast cancer stem cells transition between epithelial and…

Jul 10, 2023 · 5 shares · 15,695 followers View post →
Martin Pera
@martinperaJAX · X

RT @CellPressNews: Editor’s top pick from the last decade of @stemcellreports: Breast cancer stem cells transition between epithelial and…

Jul 10, 2023 · 5 shares · 2,380 followers View post →
VITENDER KUMAR
@VITENDERKUMAR2 · X

RT @CellPressNews: Editor’s top pick from the last decade of @stemcellreports: Breast cancer stem cells transition between epithelial and…

Jul 9, 2023 · 5 shares · 29 followers View post →
Dr. Shashank Joshi
@AskDrShashank · X

RT @CellPressNews: Editor’s top pick from the last decade of @stemcellreports: Breast cancer stem cells transition between epithelial and…

Jul 9, 2023 · 5 shares · 32,519 followers View post →
Jaroslav Novotný
@novotnyjarosl · X

RT @CellPressNews: Editor’s top pick from the last decade of @stemcellreports: Breast cancer stem cells transition between epithelial and…

Jul 9, 2023 · 5 shares · 604 followers View post →
Cell Press
@CellPressNews · X

Editor’s top pick from the last decade of @stemcellreports: Breast cancer stem cells transition between epithelial and mesenchymal states reflective of their normal counterparts @ISSCR @martinperaJAX @WichaLab https://t.co/qpjdrt0Hsy https://t.co/vQj89w8uxl

Jul 9, 2023 · 13 likes · 5 shares · 161,139 followers View post →