Clin Rheumatol April 2014 PMID 24526250

The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain.

Jarred Younger, Luke Parkitny, David McLain

Download social card

Mentions

63
Peak: 7 in Dec 2022
across 8 sources since Jan 2015

Extended reach

90,719
potential audience

Total likes

104

Video views

1,083

Mentions per month

Jan 2015 – Aug 2025

Where it's discussed

  • X / Twitter32 posts
  • Reddit13 posts
  • News7 articles
  • Facebook3 posts
  • Blogs3 articles
  • YouTube2 videos
  • Instagram2 posts
  • TikTok1 posts

AI synopsis

What people are saying

Overall, the discussions reflect a strong interest and curiosity about LDN's therapeutic potential, exemplified by questions about its mechanisms (e.g., TLR4 antagonism) and possibilities for treating inflammatory disorders. The tone indicates cautious optimism, with some referencing research papers and mechanisms, which highlights a thoughtful engagement rather than dismissiveness.

AgreementModerate agreement

Most discussions acknowledge the potential benefits and mechanisms of LDN, indicating moderate support.

InterestHigh interest

Posts show high curiosity and interest, with several examining different aspects and implications of LDN.

EngagementHigh engagement

Many figures reference research, mechanisms, or questions, demonstrating deep engagement with the topic.

ImpactModerate impact

The discussions suggest recognition of LDN's potential significance, though mainly exploratory and not conclusive.

Abstract in brief

  • Low-dose naltrexone (LDN) shows potential as a new anti-inflammatory treatment for chronic pain conditions like fibromyalgia, Crohn’s disease, multiple sclerosis, and complex regional pain syndrome by affecting microglial cells in the brain.
  • Its anti-inflammatory effects seem to be unique to low doses and are separate from its better-known role in blocking opioid receptors, making it a different kind of therapy.
  • Although LDN is inexpensive and well-tolerated, its use for chronic conditions is still experimental, with current studies limited in size and number, and more research is needed to confirm its effectiveness.

Top posts

Most liked on X and Bluesky
Michael Stingl
@neurostingl · X

Dieser Tierversuch ist spannend weil wir mit Naltrexon einen billigen TLR4-Antagonisten an der Hand hätten: https://t.co/hjctEfdrXN https://t.co/0MHGw3WUOt

Jun 9, 2022 · 28 likes · 2 shares · 16,327 followers View post →
Tess Falor, Ph.D. | Renegade Research
@tessfalor · X

@Jef_The_Leftist @Lc_weekly @ahandvanish It needs to be studied more, but I wouldn't say it's a scam. There are possible mechanisms for how it might help. https://t.co/uzFkmCsPbw (Hannah is on the low end of therapeutic dose in this article) https://t.co/NZIByVn9yS

Sep 5, 2022 · 10 likes · 9,696 followers View post →
にょろり_nyolori,Forensic DVM
@nyolotarou · X

中枢活性免疫調節剤が将来関心のある分野になると予想 コメント 中枢神経性の炎症を抑制することからme/cfsにも効果があると判定 https://t.co/32PmfwfZnw

Aug 30, 2025 · 7 likes · 1 share · 734 followers View post →
Hope
@hopestardust20 · X

The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain - PMC https://t.co/esqhpfr5Jw

Apr 23, 2023 · 6 likes · 6 shares · 2,372 followers View post →
松井健太郎 睡眠・精神医学 (Kentaro Matsui)
@matsuikentaro1 · X

低用量ナルトレキソン、抗炎症作用から、慢性疼痛に効く可能性が指摘されているらしい https://t.co/rWXd9nyJKa 気になって調べてみたけど、ナルメフェンだとそういう報告はなさそう https://t.co/IZl128KnYf

Oct 24, 2022 · 5 likes · 1 share · 7,912 followers View post →
cynomel muncher
@cynomel · X

https://t.co/EqrgDYr0MP

Jun 28, 2024 · 2 likes · 13,745 followers View post →

All mentions

猫やで
@7YzzjuywccS3RwK · X

RT @nyolotarou: 中枢活性免疫調節剤が将来関心のある分野になると予想 コメント 中枢神経性の炎症を抑制することからme/cfsにも効果があると判定 https://t.co/32PmfwfZnw

Aug 31, 2025 · 1 share · 1,015 followers View post →
にょろり_nyolori,Forensic DVM
@nyolotarou · X

中枢活性免疫調節剤が将来関心のある分野になると予想 コメント 中枢神経性の炎症を抑制することからme/cfsにも効果があると判定 https://t.co/32PmfwfZnw

Aug 30, 2025 · 7 likes · 1 share · 734 followers View post →
David Nicholas
@MolBio_Cat · X

@healingfromlc This study doesn't directly look at long COVID, but rather at the effects of LDN. (3) "The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain" https://t.co/n8P90lUfhn

Dec 22, 2024 · 1 like · 1,240 followers View post →
Billy Buffington, MD⚕️
@BillyBuffington · X

Sources: 1. Bruera E, et al. “Low-dose naltrexone use for the management of post-acute sequelae of COVID-19.” Int Immunopharmacol. 2023. https://t.co/B957W1Qu22 2. Younger J, Parkitny L, McLain D. “The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for

Nov 18, 2024 · 2 likes · 844 followers View post →
AMARESH KUMAR
@amareshskumar · X

@Thinkerks @Clynnieman @Jessica03302106 @JohnDParody As mentioned below - can start with 12.5mg (¼tablet) and see response. For details, FLCCC has some articles (hope it helps) : https://t.co/xs4AXkkWN7 https://t.co/VGZz1HRcGK https://t.co/pC2YxJH1CO

Jul 11, 2024 · 1 like · 1,284 followers View post →
cynomel muncher
@cynomel · X

https://t.co/EqrgDYr0MP

Jun 28, 2024 · 2 likes · 13,745 followers View post →
8Eevert ✨
@8Eevert · X

RT @8Eevert: 1. #naltrexone is an opioid antagonist, unrelated to benefits of low-dose naltrexone (#LDN)—https://t.co/Q14okVHF0K 2. #LDN p…

Jun 4, 2023 · 1 share · 1,173 followers View post →
Hope
@hopestardust20 · X

RT @Hopesaxons: The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain - PMC https://t.co/esqhpfr5Jw

May 15, 2023 · 6 shares · 2,372 followers View post →
Hope
@hopestardust20 · X

RT @Hopesaxons: The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain - PMC https://t.co/esqhpfr5Jw

Apr 24, 2023 · 6 shares · 2,372 followers View post →
Priceless2020 #FBLC
@Priceless20201 · X

RT @Hopesaxons: The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain - PMC https://t.co/esqhpfr5Jw

Apr 23, 2023 · 6 shares · 1,201 followers View post →
Susannah H
@firebug70 · X

RT @Hopesaxons: The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain - PMC https://t.co/esqhpfr5Jw

Apr 23, 2023 · 6 shares · 1,663 followers View post →
EsperanzaBenRam
@EsperanzaBenRam · X

RT @Hopesaxons: The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain - PMC https://t.co/esqhpfr5Jw

Apr 23, 2023 · 6 shares · 1,194 followers View post →
Hope
@hopestardust20 · X

The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain - PMC https://t.co/esqhpfr5Jw

Apr 23, 2023 · 6 likes · 6 shares · 2,372 followers View post →
SUMMER TIME
@summerhasfun · X

The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain https://t.co/d0SZKyrbuU

Mar 13, 2023 · 78 followers View post →
8Eevert ✨
@8Eevert · X

1. #naltrexone is an opioid antagonist, unrelated to benefits of low-dose naltrexone (#LDN)—https://t.co/Q14okVHF0K 2. #LDN prevents #neuroinflammation by #TLR4 antagonism—https://t.co/z7QZKZ8BsB 3. #TLR4 is significant in #Covid pathogenesis—https://t.co/ClcdcJz5kb https://t.co/U1dwzb9sfn

Feb 28, 2023 · 1 like · 1 share · 1,173 followers View post →
サプリ
@Dad84860837 · X

RT @matsuikentaro1: 低用量ナルトレキソン、抗炎症作用から、慢性疼痛に効く可能性が指摘されているらしい https://t.co/rWXd9nyJKa 気になって調べてみたけど、ナルメフェンだとそういう報告はなさそう

Oct 24, 2022 · 1 share · 122 followers View post →
松井健太郎 睡眠・精神医学 (Kentaro Matsui)
@matsuikentaro1 · X

低用量ナルトレキソン、抗炎症作用から、慢性疼痛に効く可能性が指摘されているらしい https://t.co/rWXd9nyJKa 気になって調べてみたけど、ナルメフェンだとそういう報告はなさそう https://t.co/IZl128KnYf

Oct 24, 2022 · 5 likes · 1 share · 7,912 followers View post →
Tess Falor, Ph.D. | Renegade Research
@tessfalor · X

@Jef_The_Leftist @Lc_weekly @ahandvanish It needs to be studied more, but I wouldn't say it's a scam. There are possible mechanisms for how it might help. https://t.co/uzFkmCsPbw (Hannah is on the low end of therapeutic dose in this article) https://t.co/NZIByVn9yS

Sep 5, 2022 · 10 likes · 9,696 followers View post →
Gary Robinson
@lessorfewer · X

@Naomi_D_Harvey Also a couple of papers on LDN for chronic pain and for ME/CFS, in case they are useful: https://t.co/gEeMZozmie https://t.co/I6Pkt1er3S

Aug 19, 2022 · 2 likes · 901 followers View post →
Erlend Bleken
@vitemer · X

RT @neurostingl: Dieser Tierversuch ist spannend weil wir mit Naltrexon einen billigen TLR4-Antagonisten an der Hand hätten: https://t.co/…

Jun 9, 2022 · 2 shares · 382 followers View post →
Michael Stingl
@neurostingl · X

Dieser Tierversuch ist spannend weil wir mit Naltrexon einen billigen TLR4-Antagonisten an der Hand hätten: https://t.co/hjctEfdrXN https://t.co/0MHGw3WUOt

Jun 9, 2022 · 28 likes · 2 shares · 16,327 followers View post →
Tiff-Annie
@Tiff__Annie_ · X

@angryhacademic Many articles & reviews for LDN & chronic pain, neuropathies, autoimmune and inflammatory conditions, like this one. Apologies I am new to Twitter & not versed in presenting these links more efficiently. Should put together a summary or review in time. https://t.co/MJpMSifBst

Mar 16, 2022 · 1 like · 800 followers View post →
LDN Research Trust
@LDNRTrust · X

Can Low Dose Naltrexone (LDN) block pain when something is wrong? In general, yes LDN can block pain when something is wrong. https://t.co/qMSt0faG02 Please see Dr Younger's article in the description for further information. https://t.co/OVo893Wf4h By Dr Leonard Weinstock

Nov 24, 2021 · 1,659 followers View post →
Pamela KarnBOT
@pamelakarnbach · X

https://t.co/due86YGmZF

Nov 20, 2021 · 4,661 followers View post →
Rene Sugar
@renesugar · X

The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain https://t.co/JYtOsc4sHm

Sep 28, 2021 · 1 like · 3,995 followers View post →
Pamela KarnBOT
@pamelakarnbach · X

Trying to understand why one w/allergy to aspirin, anti inflammatory meds in general would have a reaction to Embeda. Apparently naltrexone has been found to have anti inflammatory properties. Who knew? https://t.co/due86YGmZF Naltrexone can also cause issue w/udt. https://t.co/WUVGPZg8Mp

Mar 20, 2020 · 4,661 followers View post →
urban fatbiker
@urbanfatbiker · X

@Kelly @Katamac1967 Here's another reference. Note.... Naltrexone, and anti-inflammatory. And the location of the receptors being attached? A lot closer to your ....well...you know. Not the brain. https://t.co/R5McJDzeOK

Dec 18, 2019 · 1,403 followers View post →
Appalachian Wellness
@AppWellness · X

New post (The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain) has been published on Appalachian Wellness - https://t.co/V3nClZcIBh

Oct 22, 2019 · 22 followers View post →
Phelix
@Phelix_RD · X

The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain https://t.co/6MZGO9XBA8

Jul 14, 2019 · 1,468 followers View post →
Natasha Wiscombe
@NatashaWiscombe · X

The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain https://t.co/gpSDhEwagU

May 19, 2019 · 1,916 followers View post →
Gerald E Morris MD, MPH, ABOM
@GEMorrisMD · X

Could LDN (low-dose Naltrexone) be a 'silver bullet' for a lot of inflammatory disorders? What are you Thoughts on this topic? The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain https://t.co/LXIXElFtO3

Mar 28, 2019 · 132 followers View post →
ᵉⁿᵗᵉʳᵒᵛⁱʳᵃˡ ᴀᴛʏᴘɪᴄᴀʟ ᴘᴏʟɪᴏᴍʏᴇʟɪᴛɪꜱ
@AtypicalPolioME · X

@PlanBCounsellor @TinaRodwell1 @jonstoneneuro @TomKindlon @velogubbed @jenbrea The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain. https://t.co/HsvlJyOT0Y

Mar 20, 2019 · 738 followers View post →
The Stress Phenotyping Framework: A multidisciplinary ...
Blogs

https://doi.org/10.1007/s12529-019-09843-x. Amtmann, D., cook, K. F. ... s10067-014-2517-2. Young, e. S., Griskevicius, v., Simpson, J. A., waters ...

Dec 25, 2025 View →
Fundamentals of Cancer Pain Management | PDF | Pain ...
News

https://doi.org/10.1007/s10067- 014-2517-2 Epub 2014 Feb 15 45. Li Z et al (2018) Low-dose naltrexone (LDN): a promising treatment in immune-related

Dec 25, 2025 View →
PSSD Clinical Findings 2.0 - F2705
Blogs

doi:10.1007/s10067-014-2517-2. Yu, X., Riemekasten, G., and Petersen, F. 2018. Autoantibodies against muscarinic acetylcholine receptor M3 in Sjogren's ...

Dec 25, 2025 View →
Akil Palanisamy MD The TIGER Protocol An Integrative 5 Step ...
News

... 10.1007/s11356-020-10574-w. 113. Cha-Na Zhao et al., “Emerging Role of Air ... s10067-014-2517-2. 51. Guttorm Raknes and Lars Småbrekke, “Low Dose ...

Dec 25, 2025 View →
Naltrexone & Low-Dose Naltexone | PDF | Opioid | Diseases And ...
News

doi: 10.1007/s10067-014-2517-2 PMCID: PMC3962576 Activated Glia=opioid tolerance & hyperalgesia!!! When activated – glia release a variety of substances ...

Dec 25, 2025 View →
Swipe to learn more about a rising use of naltrexone. Join our LDN ...
TikTok

... 10.1007/s10067-014-2517-2 https://clinicaltrials.gov/search?term=low%20dose%20naltrexone&viewType=Table #ldn”. Cross Your Mind - Shelly.

Jul 28, 2025 View →
Two failed attempts, but I want to start again. What should I do? : r ...
Reddit

Clin Rheumatol. 2014 Apr;33(4):451-9. doi: 10.1007/s10067-014-2517-2. Epub 2014 Feb 15. PMID: 24526250; PMCID: PMC3962576. Aveirah. • ...

Jul 15, 2025 View →
Low Dose Naltrexone : r/ChronicPain
Reddit

doi: 10.1007/s10067-014-2517-2 The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain Jarred Younger 1 ...

May 10, 2025 View →
Adakah LDA dan LDA cuma menutup beberapa PEM atau ...
Reddit

doi:10.1007/s10067-014-2517-2. [2] Chopra P, Cooper MS. Rawatan Sindrom Sakit Serantau Kompleks (CRPS) Menggunakan Naltrekson Dos Rendah ...

Jan 18, 2025 View →
Do LDA and LDA just mask some PEM or do something like helping ...
Reddit

doi:10.1007/s10067-014-2517-2. [2] Chopra P, Cooper MS. Treatment of Complex Regional Pain Syndrome (CRPS) Using Low Dose Naltrexone (LDN) ...

Jan 18, 2025 View →
Machen LDA und LDA nur einige PEM-Symptome unsichtbar oder ...
Reddit

doi:10.1007/s10067-014-2517-2. [2] Chopra P, Cooper MS. Treatment of Complex Regional Pain Syndrome (CRPS) Using Low Dose Naltrexone (LDN) ...

Jan 18, 2025 View →
Делают ли ЛДА и ЛДА просто маскировку некоторых симптомов ...
Reddit

doi:10.1007/s10067-014-2517-2. [2] Chopra P, Cooper MS. Treatment of Complex Regional Pain Syndrome (CRPS) Using Low Dose Naltrexone (LDN) ...

Jan 18, 2025 View →
What is low dose naltrexone (LDN)?
News

https://doi.org/10.1007/s10067-014-2517-2; Bolton MJ, Chapman BP, Van Marwijk H. Low-dose naltrexone as a treatment for chronic fatigue ...

Oct 17, 2024 View →
Halberd/Athena GTX Research Promises a Much Brighter Future
News

... 10.1007/s10067-014-2517-2, all relate to the endorphin release as a contributing factor. The most prevalent hypothesis, advanced by Dr. Ian ...

May 22, 2024 View →
Halberd/Athena GTX Research Promises a Much Brighter Future ...
News

While there are thousands of articles attesting to the analgesic effects, such as https://link.springer.com/article/10.1007/s10067-014-2517-2 ...

May 22, 2024 View →
Astrid Boeckelmann | DID YOU KNOW iodine deficiency is the ...
Instagram

... 10.1007/s10067-014-2517-2) ➡️Are you curious to see if low-dose naltrexone could improve the symptoms you're experiencing? Book a ...

May 6, 2024 View →
“Kayli seems like she's doing better” — and that's because I am ...
Instagram

wandering on December 17, 2023: "“Kayli seems like she's doing better” — and that's because I am ☺️ I've had significant improvement thanks ...

Dec 17, 2023 View →
Check out these articles on LDN: LDN helps to normalize immune ...
Facebook

org/10.1007/s10067-014-2517-2 LDN ameliorates symptoms of Crohn's disease; PMID: 24558033 LDN and the therapeutic implications in ...

Jun 5, 2023 View →
In the months following a COVID infection, Olga Wehrly's ... - Facebook
Facebook

... 10.1007/s10067-014-2517-2). “Inflammation tends to spread, and it tends to migrate, and it tends to cause other inflammation.” As Younger ...

May 18, 2023 View →
حدّش فيكم استعمل نالتريكسون بجرعات قليلة بشكل شخصي، بس مش ...
Reddit

Clin Rheumatol. 2014 Apr;33(4):451-9. doi: 10.1007/s10067-014-2517-2. Epub 2014 Feb 15. PMID: 24526250; PMCID: PMC3962576. مزيد من الردود.

Dec 23, 2022 View →
有人**亲自**用过低剂量纳曲酮( off label )来缓解过度刺激吗? : r ...
Reddit

Clin Rheumatol. 2014 Apr;33(4):451-9. doi: 10.1007/s10067-014-2517-2. Epub 2014 Feb 15. PMID: 24526250; PMCID: PMC3962576. 更多回复.

Dec 23, 2022 View →
Hat jemand PERSÖNLICH niedrig dosiertes Naltrexon off-label ...
Reddit

Clin Rheumatol. 2014 Apr;33(4):451-9. doi: 10.1007/s10067-014-2517-2. Epub 2014 Feb 15. PMID: 24526250; PMCID: PMC3962576. Weitere Antworten.

Dec 23, 2022 View →
Has anyone PERSONALLY used low dose naltrexone off label for ...
Reddit

Clin Rheumatol. 2014 Apr;33(4):451-9. doi: 10.1007/s10067-014-2517-2. Epub 2014 Feb 15. PMID: 24526250; PMCID: PMC3962576. More replies.

Dec 23, 2022 View →
有人**親身**用過低劑量納曲酮,非標籤用於過度刺激嗎? : r ...
Reddit

Clin Rheumatol. 2014 Apr;33(4):451-9. doi: 10.1007/s10067-014-2517-2. Epub 2014 Feb 15. PMID: 24526250; PMCID: PMC3962576. 更多回覆.

Dec 23, 2022 View →
Zkoušel někdo osobně nízkodávkovaný naltrexon mimo schválené ...
Reddit

Clin Rheumatol. 2014 Apr;33(4):451-9. doi: 10.1007/s10067-014-2517-2. Epub 2014 Feb 15. PMID: 24526250; PMCID: PMC3962576. Další odpovědi.

Dec 23, 2022 View →
Quelqu'un a-t-il PERSONNELLEMENT utilisé de la naltrexone à ...
Reddit

est ce que je: 10.1007/s10067-014-2517-2. Publication en ligne du 15 février 2014. PMID : 24526250 ; PMCID : PMC3962576. Réponses ...

Dec 23, 2022 View →
'Room for improvement': Treating ankylosing spondylitis
News

2014;doi:10.1007/s10067-014-2517-2. Zhao S, et al. ArthritisTher. 2018;doi:10.1186/s13075-018-1644-6. Published by: healio rheumatology logo ...

Aug 14, 2020 View →
Pediatrician Dr. Elisa Song on PANS/PANDAS DX Treatment
Blogs

DOI 10.1007/s10067-014-2517-2. Cell Danger Response/Mast Cells : RK Naviaux. Metabolic features of the cell danger response. TC Theroharides ...

Jul 13, 2019 View →
Hi Val! What's your opinion on LDN?
Facebook

org/10.1007/s10067-014-2517-2 LDN ameliorates symptoms of Crohn's disease; PMID: 24558033 LDN and the therapeutic implications in ...

Jan 27, 2015 View →