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Stem Cell Reports February 2014 PMID 24527394

Characterization of human induced pluripotent stem cell-derived retinal pigment epithelium cell sheets aiming for clinical application.

Hiroyuki Kamao, Michiko Mandai, Satoshi Okamoto, Noriko Sakai, Akiko Suga, Sunao Sugita, Junichi Kiryu, Masayo Takahashi

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Mentions

30
Peak: 5 in Jun 2023
across 6 sources since Jan 2023

Extended reach

337,969
potential audience

Total likes

19

Video views

9

Mentions per month

Jan 2023 – Aug 2024

Where it's discussed

  • X / Twitter9 posts
  • Blogs6 articles
  • Facebook5 posts
  • Bluesky4 posts
  • News4 articles
  • YouTube2 videos

AI synopsis

What people are saying

The discussions include references to the paper as a 'classic proof-of-principle' and emphasize its importance in developing RPE cell sheets for AMD therapy, often using words like 'highlight' and 'demonstrating' to underscore its significance. The tone suggests a mix of admiration and recognition of its contribution to advancing stem cell therapies, with examples illustrating how the research aligns with long-term goals in regenerative medicine.

AgreementModerate agreement

Most discussions recognize the significance of the study and its potential for clinical use, with some explicitly supporting its findings.

InterestHigh interest

Participants show high interest, frequently emphasizing the importance of the research for treating age-related macular degeneration and noting the paper's status as a noteworthy contribution.

EngagementModerate engagement

Posts demonstrate moderate engagement by referencing the study’s implications and placing it within the context of ongoing research milestones.

ImpactModerate impact

The discussions reflect an appreciation for the potential impact on medical treatments, highlighting the study's promising approach to regenerative medicine.

Abstract in brief

  • The study focuses on creating retinal pigment epithelium (RPE) cell sheets derived from human induced pluripotent stem cells (hiPSCs) to treat age-related macular degeneration (AMD), which damages RPE and affects vision.
  • The hiPSC-derived RPE cells are designed to meet clinical standards, forming monolayer sheets that display key RPE features like tight junctions, polarized secretion, and phagocytosis, similar to natural RPE tissue, and they show safety in nonhuman primate tests without immune rejection.
  • The findings suggest that these autologous hiPSC-RPE sheets could be a promising, safe option for tissue replacement therapy in AMD patients, potentially restoring damaged retinal tissue without adverse immune responses.
Read the full abstract

Top posts

Most liked on X and Bluesky
StemCellReports
@stemcellreports · X

This week we have two papers on the eye. The first is a classic proof-of-principle paper from @masayomasayo demonstrating the application of RPE sheets to treat AMD https://t.co/kiTE0eUTar.

May 1, 2023 · 9 likes · 5 shares · 3,530 followers View post →
Cell Press
@CellPressNews · X

As we continue the countdown to the @stemcellreports 10-year anniversary in June, we highlight a classic proof-of-principle paper from @masayomasayo demonstrating the application of RPE sheets to treat AMD https://t.co/3JAHK4vra0. https://t.co/mxFPHYhAYF

May 4, 2023 · 5 likes · 2 shares · 162,033 followers View post →
Cell Press
@CellPressNews · X

Editor’s top pick from the last decade of @stemcellreports: Characterization of human induced pluripotent stem cell-derived retinal pigment epithelium cell sheets aiming for clinical application @ISSCR @martinperaJAX https://t.co/zRpkp4W4UB https://t.co/BFms0MSTms

Jun 27, 2023 · 5 likes · 4 shares · 162,033 followers View post →
ludovic vallier
@VallierLab · X

RT @stemcellreports: This week we have two papers on the eye. The first is a classic proof-of-principle paper from @masayomasayo demonstra…

May 1, 2023 · 5 shares · 3,755 followers View post →
Martin Pera
@martinperaJAX · X

RT @stemcellreports: This week we have two papers on the eye. The first is a classic proof-of-principle paper from @masayomasayo demonstra…

May 1, 2023 · 5 shares · 2,403 followers View post →
Martin Pera
@martinperaJAX · X

RT @CellPressNews: Editor’s top pick from the last decade of @stemcellreports: Characterization of human induced pluripotent stem cell-der…

Jun 27, 2023 · 4 shares · 2,403 followers View post →

All mentions

bioRxiv Cell Biology
@biorxiv-cellbio.bsky.social · Bluesky

Transcriptomic analysis and high throughput functional characterization of human induced pluripotent stem cell derived sensory neurons https://www.biorxiv.org/content/10.1101/2024.08.23.607310v1

Aug 25, 2024 View post →
bioRxivpreprint
@biorxivpreprint.bsky.social · Bluesky

Transcriptomic analysis and high throughput functional characterization of human induced pluripotent stem cell derived sensory neurons https://www.biorxiv.org/content/10.1101/2024.08.23.607310v1

Aug 25, 2024 View post →
bioRxiv Neuroscience
@biorxiv-neursci.bsky.social · Bluesky

Multielectrode array characterization of human induced pluripotent stem cell derived neurons in co-culture with primary human astrocytes. https://www.biorxiv.org/content/10.1101/2024.03.04.583341v1

Mar 8, 2024 View post →
bioRxivpreprint
@biorxivpreprint.bsky.social · Bluesky

Multielectrode array characterization of human induced pluripotent stem cell derived neurons in co-culture with primary human astrocytes. https://www.biorxiv.org/content/10.1101/2024.03.04.583341v1

Mar 8, 2024 View post →
Phenomics
@Phenomics_J · X

RT @CellPressNews: Editor’s top pick from the last decade of @stemcellreports: Characterization of human induced pluripotent stem cell-der…

Jun 27, 2023 · 4 shares · 1,524 followers View post →
Isha Verma, Ph.D.
@ivy_hederahelix · X

RT @CellPressNews: Editor’s top pick from the last decade of @stemcellreports: Characterization of human induced pluripotent stem cell-der…

Jun 27, 2023 · 4 shares · 90 followers View post →
Martin Pera
@martinperaJAX · X

RT @CellPressNews: Editor’s top pick from the last decade of @stemcellreports: Characterization of human induced pluripotent stem cell-der…

Jun 27, 2023 · 4 shares · 2,403 followers View post →
big Afc
@appiah_oxwell · X

RT @CellPressNews: Editor’s top pick from the last decade of @stemcellreports: Characterization of human induced pluripotent stem cell-der…

Jun 27, 2023 · 4 shares · 116 followers View post →
Cell Press
@CellPressNews · X

Editor’s top pick from the last decade of @stemcellreports: Characterization of human induced pluripotent stem cell-derived retinal pigment epithelium cell sheets aiming for clinical application @ISSCR @martinperaJAX https://t.co/zRpkp4W4UB https://t.co/BFms0MSTms

Jun 27, 2023 · 5 likes · 4 shares · 162,033 followers View post →
Cell Press
@CellPressNews · X

As we continue the countdown to the @stemcellreports 10-year anniversary in June, we highlight a classic proof-of-principle paper from @masayomasayo demonstrating the application of RPE sheets to treat AMD https://t.co/3JAHK4vra0. https://t.co/mxFPHYhAYF

May 4, 2023 · 5 likes · 2 shares · 162,033 followers View post →
Martin Pera
@martinperaJAX · X

RT @stemcellreports: This week we have two papers on the eye. The first is a classic proof-of-principle paper from @masayomasayo demonstra…

May 1, 2023 · 5 shares · 2,403 followers View post →
ludovic vallier
@VallierLab · X

RT @stemcellreports: This week we have two papers on the eye. The first is a classic proof-of-principle paper from @masayomasayo demonstra…

May 1, 2023 · 5 shares · 3,755 followers View post →
StemCellReports
@stemcellreports · X

This week we have two papers on the eye. The first is a classic proof-of-principle paper from @masayomasayo demonstrating the application of RPE sheets to treat AMD https://t.co/kiTE0eUTar.

May 1, 2023 · 9 likes · 5 shares · 3,530 followers View post →