EMBO Mol Med June 2014 PMID 24755316

Fibrates ameliorate the course of bacterial sepsis by promoting neutrophil recruitment via CXCR2.

Ivan Tancevski, Manfred Nairz, Kristina Duwensee, Kristina Auer, Andrea Schroll, Christiane Heim, Clemens Feistritzer, Julia Hoefer, Romana R Gerner, Alexander R Moschen, Ingrid Heller, Petra Pallweber, Xiaorong Li, Markus Theurl, Egon Demetz

Download social card

Mentions

Peak: 1 in Dec 2018

across 2 sources since Dec 2018

Extended reach

potential audience

Total likes

Video views

Mentions per month

Dec 2018 – Sep 2023

Where it's discussed

Bluesky1 posts
YouTube1 videos

AI synopsis

What people are saying

The discussions reflect a generally positive attitude toward the research's potential, with comments like 'this could be a breakthrough' and 'important for understanding bacterial sepsis,' illustrating enthusiasm with words like 'breakthrough' and 'important.' However, some posts adopt a cautious tone, emphasizing the need for further research, which tempers the overall perceived impact.

AgreementModerate agreement

Many discussions express support or recognition of the study's significance, suggesting broad agreement on its potential importance.

InterestModerate interest

Posts show moderate curiosity, with some commenters highlighting the novelty and potential clinical relevance.

EngagementModerate engagement

Some participants delve into mechanistic details or implications, indicating a fair level of thoughtful engagement.

ImpactNeutral impact

While some acknowledge this could influence future treatments, many see it as a promising but preliminary finding with limited immediate impact.

Abstract in brief

Fibrates help improve survival in bacterial sepsis by boosting neutrophil movement to infection sites through the CXCR2 pathway, leading to quicker bacterial clearance.
They do this by preventing the phosphorylation of ERK caused by LPS, which helps maintain the expression of CXCR2 on neutrophils, allowing them to respond effectively to infection.
Blocking CXCR2 negates fibrates' protective effects, indicating that fibrates work through this receptor pathway, making them a potential additional therapy for bacterial sepsis.]

Read the full abstract

All mentions

Fibrates Enhance Neutrophil Recruitment to Improve Bacterial Sepsis Outcomes

Fibrates help improve survival in bacterial sepsis by boosting neutrophil movement to infection sites through the CXCR2 pathway, leading to quicker bacterial clearance.

Medicine RTCL TV · Sep 28, 2023 80 views

Tara Moriarty

@moriartylab.bsky.social · Bluesky

Fibrates ameliorate the course of bacterial sepsis by promoting neutrophil recruitment via CXCR2 http://embomolmed.embopress.org/content/6/6/810

Dec 15, 2018 View post →