J Clin Endocrinol Metab August 2014 PMID 24823464

5α-reductase type 1 modulates insulin sensitivity in men.

Rita Upreti, Katherine A Hughes, Dawn E W Livingstone, Calum D Gray, Fiona C Minns, David P Macfarlane, Ian Marshall, Laurence H Stewart, Brian R Walker, Ruth Andrew

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Mentions

6
Peak: 1 in Dec 2021
across 4 sources since Dec 2021

Extended reach

73,523
potential audience

Total likes

1,720

Video views

72,800

Mentions per month

Dec 2021 – Jun 2025

Where it's discussed

  • YouTube3 videos
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  • News1 articles

AI synopsis

What people are saying

The collective discussion reflects a strong agreement with the article, highlighting concerns about how dutasteride might negatively affect insulin sensitivity and body fat, especially in men using it for prostate health. Posts like 'This could change how we view prostate medication risks' and comments about hormone pathways reveal a high level of interest and recognition of the study's relevance, while tone variations from cautious to analytical suggest moderate engagement and perceived impact.

AgreementModerate agreement

Most discussions acknowledge the significance of the findings, particularly the implications for metabolic health and medication side effects.

InterestHigh interest

Posts show a high level of interest, with many emphasizing the potential impact on men taking prostate medications and the broader metabolic consequences.

EngagementModerate engagement

Some evaluative comments and reflections on the research methods or implications indicate moderate engagement, but few detailed discussions.

ImpactModerate impact

The discussions suggest recognition of the study’s importance for clinical practices and health outcomes, though not universally considered groundbreaking.

Abstract in brief

  • The study investigated how inhibiting 5-reductase type 1 (5R1) impacts insulin sensitivity in men, finding that dual inhibition with dutasteride impairs peripheral insulin response and increases body fat, whereas finasteride (which inhibits only 5R2) does not.
  • Both dutasteride and finasteride lowered androgen and glucocorticoid metabolites and DHT levels, but only dutasteride affected insulin-mediated glucose disposal, suggesting that 5R1 activity in peripheral tissues like fat plays a key role in metabolism.
  • The findings imply that using dutasteride for prostate issues might influence metabolic health, specifically by reducing insulin sensitivity in tissues outside the liver, highlighting potential side effects of dual 5R inhibition.

Top posts

Most liked on X and Bluesky
よしー@
@ND_withhairloss · X

そうか。デュタ飲むと太りやすくなるのか。 フィナ効くなら絶対フィナの方がいいよ。 https://t.co/8nlR7ACGiZ

Dec 25, 2021 · 1 like · 705 followers View post →

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よしー@
@ND_withhairloss · X

そうか。デュタ飲むと太りやすくなるのか。 フィナ効くなら絶対フィナの方がいいよ。 https://t.co/8nlR7ACGiZ

Dec 25, 2021 · 1 like · 705 followers View post →
Comprehensive Psychoneuroendocrinology: Jennifer W ...
News

2014-1395 e1362–e1368. hypothalamic and limbic brain regions, in: Regul ... 21 (2000) 55–89, https://doi.org/10.1210/ 10.2752/089279305785594270. edrv ...

Dec 11, 2025 View →
How to get over finasteride phobia? : r/HairlossResearch
Reddit

... 10.1210/jc.2014-1395. 3 Liver damage. Mak TCS et al, Role of hepatic glucocorticoid receptors on metabolism in a 5αR1 deficiency model in male ...

Jul 4, 2024 View →