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Overall, the social discussions show a positive reception, with comments highlighting pregnenolone's potential as a safe treatment for bipolar depression, as well as curiosity about its biological mechanisms, using words like 'significantly improved' and 'possible biological mechanism' that signal a mix of interest and cautious optimism.
Most discussions recognize pregnenolone's potential benefits for bipolar depression, with some noting it as a promising or safe option, reflecting general agreement and cautious optimism.
The topic draws high interest due to its relevance to mental health treatment and neurosteroid research, evident from phrases like 'can improve depressive symptoms' and 'minimal adverse effects'.
Participants engage by referencing biological mechanisms, emphasizing the significance of neurosteroids, and considering practical implications, though some comments remain at a surface level.
The discussions suggest the publication could influence future research directions or clinical approaches to bipolar depression, albeit with some skepticism about the need for further validation.
A randomized, double-blind. placebo-controlled trial of modulating the gut microbiome is successful for symptom alleviation in Long Covid www.thelancet.com/journals/lan...
Study: A randomized, double-blind, placebo-controlled trial of niclosamide nanohybrid for the treatment of patients with mild to moderate COVID-19 Published: 01 August 2025 www.nature.com/articles/s41...
Hormone deficiencies are often an underlying cause of depression. Pregnenolone can improve depressive symptoms in bipolar patients with minimal adverse effects. https://t.co/DUJXgD44JY
New PubPeer comment on "Efficacy of oral folinic acid supplementation in children with autism spectrum disorder: a randomized double-blind, placebo-controlled trial" (Panda et al, 2024). Concerns about significant errors. #folinicacid #leucovorin, #autism pubpeer.com/publications...
New in #ASNJASN and at #Hypertension25: In a randomized, double-blind, placebo-controlled trial, Baxdrostat reduced systolic blood pressure in patients with CKD and uncontrolled hypertension. Read more about its safety and efficacy in patients with CKD here: kidney.pub/JASN0849
RETRACTED: Clinical and metabolic response to probiotic administration in people with Parkinson's disease: A randomized, double- blind, placebo- controlled trial It happens too many times, takes time and undermines science in general. www.sciencedirect.co...
Some claim pregnenolone can increase testosterone levels, but is this true? This video explains the hormone precursor's role and what current research says about its effects on testosterone.
This video discusses the role of supplementation in bipolar disorder (TAB) treatment, including traditional approaches, contraindicated supplements, and recent research on integrating safe supplements like NAC and…
What did a randomized, double-blind, placebo-controlled trial of hibiscus tea for weight loss find?
Effects of a spore-forming probiotic blend on bowel habits and physical well-being in adults with functional constipation: a randomized, double-blind, placebo-controlled trial https://www.medrxiv.org/content/10.1101/2025.11.05.25339581v1
Effects of Continuous Oral Intake of DR.ERGO(R) Ergothioneine Capsules on Skin Status: A Randomized, Double-Blind, Placebo-Controlled Trial https://www.medrxiv.org/content/10.1101/2025.10.16.25337962v1
A randomized, double-blind, placebo-controlled trial of niclosamide nanohybrid for the treatment of patients with mild to moderate #COVID19 #DrugDiscovery #SarsCoV2 #COVID
A randomized, double-blind, placebo-controlled trial of niclosamide nanohybrid for the treatment of patients with mild to moderate #COVID19 #DrugDiscovery #SarsCoV2 #COVID
Some interesting PubPeer comments on "Efficacy of oral folinic acid supplementation in children with autism spectrum disorder: a randomized double-blind, placebo-controlled trial" pubpeer.com/publications...
New PubPeer comment on "Efficacy of oral folinic acid supplementation in children with autism spectrum disorder: a randomized double-blind, placebo-controlled trial" (Panda et al, 2024). Concerns about significant errors. #folinicacid #leucovorin, #autism pubpeer.com/publications...
Lactucin, the hypnotic component of lettuce, is put to the test in a randomized, double-blind, placebo-controlled trial of lettuce seeds.
2024 paper on use of oral leucovorin in autism spectrum disorder with folate receptor auto-antibodies
JMIR Res Protocols: Effectiveness of Tocotrienol-Rich Fraction in Older Adults: #Protocol for a Randomized, Double-Blind, Placebo-Controlled Trial
Study Design: HI-PRO was a randomized, double-blind, placebo-controlled trial. 600 patients with provoked VTE + ≥1 enduring risk factor received apixaban 2.5mg BID vs. placebo for 12 months after completing ≥3 months of initial anticoagulation. 3/8
Efficacy and Safety of Baxdrostat in Participants with CKD and Uncontrolled #Hypertension: A Randomized, Double-Blind, Placebo-Controlled Trial ca. 2025 from @asnpublications.bsky.social @escardio.bsky.social #Nephpearls #NephSky #ESCCongress
New in #ASNJASN and at #Hypertension25: In a randomized, double-blind, placebo-controlled trial, Baxdrostat reduced systolic blood pressure in patients with CKD and uncontrolled hypertension. Read more about its safety and efficacy in patients with CKD here: kidney.pub/JASN0849
RETRACTED: Clinical and metabolic response to probiotic administration in people with Parkinson's disease: A randomized, double- blind, placebo- controlled trial It happens too many times, takes time and undermines science in general. www.sciencedirect.co...
Study: A randomized, double-blind, placebo-controlled trial of niclosamide nanohybrid for the treatment of patients with mild to moderate COVID-19 Published: 01 August 2025 www.nature.com/articles/s41...
A randomized, double-blind, placebo-controlled trial of #niclosamide nanohybrid for #treatment of patients with mild to moderate #COVID19, etidiohnew.blogspot.com/2025/08/a-ra...
A randomized, double-blind, placebo-controlled trial of niclosamide nanohybrid for the treatment of patients with mild to moderate COVID-19 ->Nature | #Covid19 | More info from EcoSearch
People won’t take a vaccine tested in a randomized, double-blind, placebo-controlled trial w/ over 70,000 participants but they’ll pay thousand to regularly inject (possibly cancer-causing) peptides w/ zero scientific data because Paltrow or RFK Jr. or some other “wellness” con-artist promotes it.
Scientists from the Food and Drug Administration’s Division of Applied Regulatory Science carried out a randomized double-blind placebo-controlled trial last year to assess how low-dose CBD affects liver function in a group of healthy middle-aged men and women.
What were the results of a randomized, double-blind, placebo-controlled trial of a daily half teaspoon of powdered black cumin in Hashimoto’s patients?
A randomized, double‐blind, placebo‐controlled trial of abatacept for the treatment of relapsing, non‐severe, granulomatosis with polyangiitis - Langford - Arthritis & Rheumatology - Wiley Online Library acrjournals.onlinelibrary.wiley.com/doi/10.1002/...
A randomized, double-blind, placebo-controlled trial of abatacept for the treatment of relapsing, non-severe, granulomatosis with polyangiitis
A randomized, double-blind, placebo-controlled trial of abatacept for the treatment of relapsing, non-severe, granu… pubmed.ncbi.nlm.nih.gov/40506793/
A randomized, double-blind, placebo-controlled trial involving patients with #WernerSyndrome found that #NicotinamideRiboside supplementation increased #NAD levels in blood and counteracted the clinical features associated with the syndrome. #AcceleratedAging
A randomized double-blind placebo-controlled trial in 2015 published in Complementary Therapies in Medicine revealed that 2 grams of ginger daily significantly reduced fasting blood sugar and HbA1c in type 2 diabetics over 12 weeks.
매크로 1번. A randomized, double-blind, placebo-controlled trial suggests
A Randomized, Double-blind, Placebo-Controlled Trial of Terminalia Chebula and Terminalia Bellerica For Hyperuricemia www.thefocalpoints.com/p/a-randomiz...
Long-term egg-protein hydrolysate consumption improves endothelial function: a randomized, double-blind, placebo-controlled trial in older adults with overweight or obesity. Eur J Nutr 2024 2/5
Evaluation of the Efficacy of the Traditional Chinese Medicine Formulation Ru-Yi-Jin-Huang-Saan on Colles Fracture After Surgery: Protocol for a Randomized, Double-Blind, Placebo-Controlled Trial - a @jmirpub.bsky.social Research Protocols article on #ScienceOpen: www.scienceopen.com/document?vid...
JMIR Res Protocols: Evaluation of the Efficacy of the Traditional Chinese Medicine Formulation Ru-Yi-Jin-Huang-Saan on Colles Fracture After Surgery: #Protocol for a Randomized, Double-Blind, Placebo-Controlled Trial
A randomized, double-blind, placebo controlled trial of IL-7 in critically ill COVID-19 patients revealed reduced nosocomial infections insight.jci.org/articles/vie... @jci-insight.bsky.social
Open Access UCL Research: IL-1 Signal Inhibition in Alcohol-Related Hepatitis: A Randomized, Double-Blind, Placebo-Controlled Trial of Canakinumab discovery.ucl.ac.uk/id/eprint/10...
#STAREE (Statins in Reducing Events in the Elderly) trial, which is a randomized, double-blind, placebo-controlled trial among community-dwelling older people Can't wait to see the results of this trial... pubmed.ncbi.nlm.nih.gov/39548016/
Inhaled Nitric Oxide in Fibrotic Lung Disease: A Randomized, Double-Blind, Placebo-controlled Trial @atscommunity.bsky.social #medsky
last night was a randomized double blind placebo controlled trial
Pamidronate for pain in adult chronic nonbacterial osteitis. #18FNaF #nucmed #molrad #nuclearmedicine #nuclearradiology #molecularimaging #petct #petmri #precisionmedicine #precisionimaging doi.org/10.1093/jbmr...
Bovhyaluronidase azoximer for long-term pulmonary sequelae of COVID-19: a randomized, double-blind, placebo-controlled trial https://www.medrxiv.org/content/10.1101/2024.09.19.24313792v1
Hydroxychloroquine treatment for recurrent pregnancy loss: a study protocol for a randomized, double-blind, placebo-controlled trial. https://www.medrxiv.org/content/10.1101/2024.05.23.24307818v1
A randomized, double-blind. placebo-controlled trial of modulating the gut microbiome is successful for symptom alleviation in Long Covid www.thelancet.com/journals/lan...
A Randomized, Double-Blind, Placebo Controlled Trial to Assess the Effectiveness and Safety of Melatonin and Three Formulations of Floraworks Proprietary TruCBN for Improving Sleep. https://www.medrxiv.org/content/10.1101/2023.11.07.23298230v1
Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with [ME/CFS]: A Randomized, Double-Blind, Placebo-Controlled Trial www.mdpi.com/2072-6643/15... #MEcfs #CFS #MyalgicE #PwME #MyalgicEncephalomyelitis #ChronicFatigueSyndrome
Safety and Efficacy of Disulfiram in Hospitalized Patients with Moderate COVID-19: A Randomized, Double-Blind, Placebo-Controlled Trial. https://www.medrxiv.org/content/10.1101/2023.10.25.23297554v1
The efficacy of influenza vaccination in elderly individuals. A randomized double-blind placebo-controlled trial | @scoopit
Probiotic Bifidobacterium longum BB68S Improves Cognitive Functions in Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial https://www.mdpi.com/2072-6643/15/1/51
Nobility Trial Rich Furie et al @HofNorthwellDOM B-cell depletion with obinutuzumab for the treatment of proliferative lupus nephritis: a randomized, double-blind, placebo-controlled trial https://ard.bmj.com/content/81/1/100.long
RT @drmikehart: Hormone deficiencies are often an underlying cause of depression. Pregnenolone can improve depressive symptoms in bipolar…
RT @drmikehart: Hormone deficiencies are often an underlying cause of depression. Pregnenolone can improve depressive symptoms in bipolar…
Hormone deficiencies are often an underlying cause of depression. Pregnenolone can improve depressive symptoms in bipolar patients with minimal adverse effects. https://t.co/DUJXgD44JY
... 10.1038/tp.2014.138. through GSK3, Curr Pharm Des 24 (33) (2019) 3868–3877 ... npp.2013.23. org/10.1093/brain/awn049. [112] R.A. Steingart, I. Gozes ...
https://doi.org/10.1038/mp.2014.138. of the microbiome. [7] Carhart-Harris ... 1038/npp.2017.84. or truffles) or as synthetic substance produces similar ...
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