Essential functions of iron-requiring proteins in DNA replication, repair and cell cycle control.

Abstract in brief

• The text explains that eukaryotic cells depend on iron-requiring proteins like FeS cluster proteins, hemoproteins, and RNRs for essential processes such as DNA replication, repair, and cell cycle regulation, with disruptions in iron homeostasis leading to genetic diseases.
• It highlights that these proteins utilize iron as a cofactor to perform their functions and that organisms have evolved complex mechanisms to regulate iron levels, which are crucial for maintaining genome stability and proper cell development.
• The review summarizes recent research on how iron homeostasis functions in yeast and mammals, emphasizing the role of iron-requiring proteins in maintaining DNA integrity and controlling the cell cycle.]