Am J Psychiatry October 2014 PMID 25018057

Effects of post-session administration of methylene blue on fear extinction and contextual memory in adults with claustrophobia.

Michael J Telch, Aleksandra K Bruchey, David Rosenfield, Adam R Cobb, Jasper Smits, Sandra Pahl, F Gonzalez-Lima

Mentions

15
Peak: 2 in May 2024
across 5 sources since Mar 2022

Extended reach

71,510
potential audience

Total likes

475

Video views

19,197

Mentions per month

Mar 2022 – Sep 2025

Where it's discussed

  • X / Twitter7 posts
  • YouTube2 videos
  • Facebook2 posts
  • Reddit2 posts
  • Blogs2 articles

AI synopsis

What people are saying

The discussions range from highlighting the historical significance of methylene blue to skepticism about its current hype as a nootropic, with some posters referencing specific studies or comparing it to newly developed drugs. The tone varies from factual to dismissive, which affects the overall neutral to slightly skeptical view of its impact.

AgreementNeither agree nor disagree

The posts show mixed reactions, with some recognizing the potential benefits of methylene blue, while others dismiss it as overhyped or trivialized.

InterestModerate interest

Interest levels are moderate, with some posters intrigued by its history and applications, but others mainly dismissing it as a supplement or nootropic.

EngagementModerate engagement

Engagement is casual and somewhat superficial, with a few posts referencing the article or its findings but mostly sharing opinions or brief mentions.

ImpactNeutral impact

The overall discussion does not seem to significantly influence opinions or public health perceptions, mostly reflecting curiosity or skepticism.

Abstract in brief

  • The study investigated whether giving methylene blue after fear extinction training could improve memory retention and reduce fear renewal in adults with claustrophobia, finding that it helped those with low posttraining fear but worsened outcomes for those with moderate to high fear.
  • Methylene blue was administered immediately after extinction trials in a controlled experiment, with fear and memory assessed one month later, showing that it enhanced long-term fear extinction in participants who showed low fear levels post-training.
  • The effects of methylene blue on fear extinction depended on the success of the initial exposure session—helping with memory in successful cases but potentially hindering those with less effective extinction, indicating its impact varies based on initial fear response.

Top posts

Most liked on X and Bluesky
darkmodebiohacking
@darkmodebio · X

Methylene Blue was the world’s first synthetic medicine, first used against malaria. Now it’s trending online as a nootropic. I break down the history, mechanisms, and human studies here: https://t.co/wnIvZAjlqV https://t.co/X9p5qHle9y

Sep 24, 2025 · 2 likes · 75 followers View post →
Luisa7371
@MluisaSAV · X

@FerFalabella Reduce los recuerdos de miedo y ansiedad https://t.co/k3gbmsWHFS Mejora los síntomas de trastorno bipolar https://t.co/kAdLKPwe4j Mejora la memoria y la neuroprotección https://t.co/ezcJTUM4CX

May 31, 2024 · 1 like · 184 followers View post →
Terra cremada
@terra_cremada · X

Reduce los recuerdos de miedo y ansiedad https://t.co/RAahJSMeEh Mejora los síntomas de trastorno bipolar https://t.co/RmdNBE4Ox0 Mejora la memoria y la neuroprotección https://t.co/TmTs2Hbi2w Página para Revisar Interacciones de Medicamentos https://t.co/em4mAS7VTC

Aug 28, 2024 · 43,604 followers View post →
Lina
@Linaguasca · X

Millora l'Alzheimer en millorar el metabolisme i la producció energètica. https://t.co/ubw2FBFdQD Redueix els records de por i ansietat https://t.co/6wlxUUaElN Millora els símptomes de trastorn bipolar https://t.co/ohdb5r27As D3ACE2C595AADA7AF7410A8EF7BAF6D5

May 30, 2024 · 7,291 followers View post →
TommyTenacious
@TommyTenacious · X

WTF people are supplementing with Methylene Blue, you've got to be kidding, a nootropic?! LOL Then I read: a published paper (linked). Wow, more human trials have been conducted involving Methylene Blue ingestion/supplementation than the new Pfizer drug

Oct 13, 2022 · 590 followers View post →
Vini
@whoisvinii · X

https://t.co/DJ3B8EPxRJ https://t.co/rJjiGe5WHF https://t.co/e1l43WUzy0 https://t.co/3cAU0tnJGU

Jul 3, 2024 · 554 followers View post →

All mentions

darkmodebiohacking
@darkmodebio · X

Methylene Blue was the world’s first synthetic medicine, first used against malaria. Now it’s trending online as a nootropic. I break down the history, mechanisms, and human studies here: https://t.co/wnIvZAjlqV https://t.co/X9p5qHle9y

Sep 24, 2025 · 2 likes · 75 followers View post →
Terra cremada
@terra_cremada · X

Reduce los recuerdos de miedo y ansiedad https://t.co/RAahJSMeEh Mejora los síntomas de trastorno bipolar https://t.co/RmdNBE4Ox0 Mejora la memoria y la neuroprotección https://t.co/TmTs2Hbi2w Página para Revisar Interacciones de Medicamentos https://t.co/em4mAS7VTC

Aug 28, 2024 · 43,604 followers View post →
Vini
@whoisvinii · X

https://t.co/DJ3B8EPxRJ https://t.co/rJjiGe5WHF https://t.co/e1l43WUzy0 https://t.co/3cAU0tnJGU

Jul 3, 2024 · 554 followers View post →
Luisa7371
@MluisaSAV · X

@FerFalabella Reduce los recuerdos de miedo y ansiedad https://t.co/k3gbmsWHFS Mejora los síntomas de trastorno bipolar https://t.co/kAdLKPwe4j Mejora la memoria y la neuroprotección https://t.co/ezcJTUM4CX

May 31, 2024 · 1 like · 184 followers View post →
Lina
@Linaguasca · X

Millora l'Alzheimer en millorar el metabolisme i la producció energètica. https://t.co/ubw2FBFdQD Redueix els records de por i ansietat https://t.co/6wlxUUaElN Millora els símptomes de trastorn bipolar https://t.co/ohdb5r27As D3ACE2C595AADA7AF7410A8EF7BAF6D5

May 30, 2024 · 7,291 followers View post →
TommyTenacious
@TommyTenacious · X

WTF people are supplementing with Methylene Blue, you've got to be kidding, a nootropic?! LOL Then I read: a published paper (linked). Wow, more human trials have been conducted involving Methylene Blue ingestion/supplementation than the new Pfizer drug

Oct 13, 2022 · 590 followers View post →
Project_Monarch
@Project_Monarch · X

https://t.co/ph1tmDaYWM

Mar 19, 2022 · 16 followers View post →