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Overall, the discussions show a scientific curiosity about molecular mechanisms such as mTOR signaling and autophagy, with some posts referencing specific experimental results like unchanged protein degradation markers or decreased mTOR phosphorylation. The tone ranges from casual fun to scientific curiosity, indicating moderate engagement and interest in the study's implications.
Most posts imply some level of agreement with the significance of the findings, such as the mention of
Discussions reflect moderate interest, with some posts exploring mechanistic details like mTOR and autophagy but not deeply delving into broader implications.
Posts reference specific molecular markers like MAFbx, MURF1, LC3B-II, and mTOR phosphorylation, indicating active engagement.
The discussion around lifespan extension and fast-mimicking treatments suggests awareness of potential impact, though not universally emphasized.
@Mangan150 @jasonmpeirce @naval Nice. "Leontieva et al recently showed that a once-weekly treatment with rapamycin extends lifespan in high fat-fed mice without altering glucose or insulin levels" https://t.co/n97GkGz0Qy So it's fast mimicking? https://t.co/Ze3vNPE7cu Fun.
@JScholar נכון שהמחקרים הזמינים קצרי טווח, אבל מה שוודאי הוא ש TRE מפחית אינסולין, גלוקוז וחומצות אמינו רגולטרים של mTOR. בנוסף IGF-1 (עוד פרוקסי ל mTOR) נמוך שיטתית באוכלוסיות שלא צורכות הרבה חלבון מהחי. אין טענה ל״ניסים״, אלא שזו פרקטיקה פשוטה ויעילה בכיוון חיובי. https://t.co/qxnncqsOEo
@kagashin_sub 糖新生の分はあるが、水のみ48時間断食でも特に分解が活性化されているわけでもなさそう "MAFbx and MURF1 ubiquitin ligases remained unaltered after fasting indicating no change in protesomal protein degradation." https://t.co/MI0cAlOpGR
@miklosch @Manni75057232 https://t.co/uAjBlPRMb4
@NarfGb mTOR phosphorylation was decreased by ∼50% following fasting, https://t.co/r5wrHRIiTJ
Autophagy initiation is in part regulated by mTOR through ULK1 and fasting increased expression of the autophagic marker LC3B-II by ∼30%." 2/ https://t.co/AKg3eumMJZ
This video explores how Chaperone-Mediated Autophagy (CMA) degrades proteins, influencing neurodegenerative and metabolic disorders, and its potential as a target for therapies in age-related diseases.
This video explores autophagy as it relates to homeostasis, a vital process for maintaining internal stability amid external changes. Grasping the importance of these concepts is crucial for understanding physiology and…
This video explains how autophagy is a cellular recycling mechanism that occurs constantly and intensifies during fasting. It clarifies misconceptions, highlights its role in health and disease, and discusses how…
In this video, discover the optimal protocol for breaking a 72-hour fast. We focus on managing insulin response and maximizing metabolic benefits. Learn about nutritional strategies that safeguard against refeeding…
@JScholar נכון שהמחקרים הזמינים קצרי טווח, אבל מה שוודאי הוא ש TRE מפחית אינסולין, גלוקוז וחומצות אמינו רגולטרים של mTOR. בנוסף IGF-1 (עוד פרוקסי ל mTOR) נמוך שיטתית באוכלוסיות שלא צורכות הרבה חלבון מהחי. אין טענה ל״ניסים״, אלא שזו פרקטיקה פשוטה ויעילה בכיוון חיובי. https://t.co/qxnncqsOEo
@kagashin_sub 糖新生の分はあるが、水のみ48時間断食でも特に分解が活性化されているわけでもなさそう "MAFbx and MURF1 ubiquitin ligases remained unaltered after fasting indicating no change in protesomal protein degradation." https://t.co/MI0cAlOpGR
@NarfGb mTOR phosphorylation was decreased by ∼50% following fasting, https://t.co/r5wrHRIiTJ
Autophagy initiation is in part regulated by mTOR through ULK1 and fasting increased expression of the autophagic marker LC3B-II by ∼30%." 2/ https://t.co/AKg3eumMJZ
@miklosch @Manni75057232 https://t.co/uAjBlPRMb4
@Mangan150 @jasonmpeirce @naval Nice. "Leontieva et al recently showed that a once-weekly treatment with rapamycin extends lifespan in high fat-fed mice without altering glucose or insulin levels" https://t.co/n97GkGz0Qy So it's fast mimicking? https://t.co/Ze3vNPE7cu Fun.
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