To try to live longer, billionaires are taking a pill that costs pennies. So, uh… does it work?
Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls.
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Sep 2019 – Aug 2025Where it's discussed
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What people are saying
Discussions reveal a strong interest in the possibility that metformin could extend lifespan, exemplified by users mentioning specific studies like Bannister et al. (2014) and the TAME trial, and expressing curiosity about its broader health effects, with a tone that balances skepticism and optimism that signals meaningful engagement and recognition of impact.
Most discussions support the idea that metformin may promote longevity, referencing studies like Bannister et al. (2014) and the TAME trial, though some express skepticism about the extrapolation to non-diabetics.
Posts show high curiosity, with many referencing videos explaining metformin's potential, and users actively engaging with study details and implications.
Participants analyze the study's findings, question causation versus correlation, and discuss potential benefits beyond diabetes management, indicating deep engagement.
While some see the findings as potentially transformative, especially given the cost-effectiveness of the drug, others remain cautious, reflecting moderate perceived impact before definitive proof.
Abstract in brief
- The study aimed to determine whether increased cardiovascular risk and mortality in diabetes patients was due to harmful effects of sulphonylureas or beneficial effects of metformin by comparing all-cause mortality in patients treated with either drug.
- Researchers analyzed data from the UK Clinical Practice Research Datalink, comparing 78,241 patients on metformin, 12,222 on sulphonylureas, and 90,463 matched non-diabetic individuals over a total follow-up period of 503,384 years.
- Findings indicated that patients on metformin had better survival rates than matched non-diabetic controls, while those on sulphonylureas faced a significant reduction in survival compared to both metformin patients and non-diabetic individuals.
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Most liked on X and BlueskyReferences: https://t.co/XsVPJGFAbp https://t.co/CsSaw7YzQY https://t.co/PnWNp9Z4vC https://t.co/vFVUftHdtj https://t.co/Vc9y4ShTTD https://t.co/lfBKrHNAO4 https://t.co/HWl72VwLiQ https://t.co/1u1oIOJ0NR
La publi décrite dans le docu, c'est celle-ci : https://t.co/dTSEtaJ2C2 Elle a pratiqué un ajustement pour atteindre non pas "17%" mais "15%", et c'est pas super fiable pour plein de limitations évoquées... Résultats contredits ici : https://t.co/Y0k49un93U ⬇️ https://t.co/X4Wweuz6u3
https://t.co/nUu0AVdwUv ①糖尿病患者でメタホルン摂取グループ VS ②糖尿病でなく、メタホルンも摂取していないグループ ②のグループは糖尿病でないにもかかわらず、ライフスパン(寿命)は①のグループに比べて15%も短かった https://t.co/cXv4QXo0gS
Entertained to see that I got a (very tiny!) cameo in @cleoabram’s new video on anti-aging drug metformin! And it’s a great video whose conclusion I completely agree with. I get asked about metformin all the time and this is basically what I say: https://t.co/SAsrIxuueb
There is some evidence that metformin helps do this in people with diabetes. In the video, we walk through the study that got Dr. Barzilai interested. BUT it's not clear that the whole "dying less" thing applies equally to people without diabetes. https://t.co/QMVEDN6PjB
All mentions
Exploring Metformin: Anti-Aging Potential and Current Research
Metformin is an old, inexpensive drug primarily used for diabetes management, now gaining attention for its potential anti-aging benefits. In this video, we discuss the research surrounding metformin, including its…
Exploring Anti-Aging Drugs and Lifespan Extension Studies
Discover real anti-aging drugs in this video. We delve into the effects of various substances such as rapamycin, metformin, and the impactful role of 17-a-estradiol in extending lifespan based on recent studies. Learn…
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Metformin and Sulphonylurea Impact on Mortality and Longevity
The study investigates whether increased cardiovascular risk and mortality in diabetes patients are due to sulphonylureas or benefits of metformin. Data shows metformin users have better survival rates than…
Metformin's Impact on Longevity in Type 2 Diabetes Patients
This study compares mortality rates of type 2 diabetes patients treated with metformin or sulphonylureas to non-diabetic controls, highlighting potential benefits of metformin for longevity and the risks associated with…
Understanding Aging: Biological, Systemic, and Statistical Perspectives
This video explores the question why we age at four levels of complexity using stories, biology, statistics, and systems biology to provide a comprehensive understanding of aging.
youtu.be/sFbghkE0WYo?... This is one of the cheapest and most effective drugs on Earth but of course there is no magic pill.
@davidasinclair David Sinclair https://t.co/vmbdCFyeCN https://t.co/VN6ibzEpKv https://t.co/U0BkU1irZP https://t.co/44NfnvGi3Z https://t.co/Jp5fOjhBcb https://t.co/XjhwQ2ELzi https://t.co/eZ8m3IO72D
@siimland @davidasinclair https://t.co/vmbdCFyeCN https://t.co/VN6ibzEpKv https://t.co/U0BkU1irZP https://t.co/44NfnvGi3Z https://t.co/Jp5fOjhBcb https://t.co/XjhwQ2ELzi https://t.co/eZ8m3IO72D
## Immortality Theater Nobody knows what works best for your body, but we can't let anything keep us from trying our best. Here's some ideas about health I've found. https://t.co/abmxIr13f4
Metformin, the Big New "Anti-Aging" Drug, Explained https://t.co/Ik5kcNlqRw via @YouTube
Can people with type 2 diabetes live longer than those without? https://t.co/ljTM5jyM0A
https://t.co/eiY0ued5YL
## Immortality Theater Nobody knows what works best for your body, but we can't let anything keep us from trying our best. Here's some ideas about health I've found. https://t.co/abmxIr13f4
https://t.co/PvVTXOFPUC
Is metformin the new anti-aging drug? https://t.co/1wpnf7YCna
Metformin, the Big New "Anti-Aging" Drug, Explained https://t.co/VBaiykRYRE via @YouTube
https://t.co/Kcbzik6jVG
@Madam_Mito That’s NOT a trial but observational data 2nd It’s not true as shown here: https://t.co/UDMtnSbSge And least but MOST important - plenty of life extended signalling paths https://t.co/EiJaxjqooA
## Immortality Theater Nobody knows what works best for your body, but we can't let anything keep us from trying our best. Here's some ideas about health I've found. https://t.co/abmxIr13f4
https://t.co/EyIRVweOq1
TAME Trial https://t.co/AfsfwUflKc Keys et al. (2022) https://t.co/9qy2Lhqvvw Bannister et al. (2014) https://t.co/GPw4bEfasD
@OkieLibSherry @EvolaVonValor @_celia_bedelia_ I guess type 2 diabetes must be healthy since they live longer if on metformin than no diabetics lol. Jfc it’s almost like medical interventions work lol.
RT @agingdoc1: Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin…
RT @agingdoc1: Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin…
Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls (2014) https://t.co/wu0eCQfOIr
Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non‐diabetic controls - Bannister - 2014 - Diabetes, Obesity and Metabolism - Wiley https://t.co/8SeCyQOHDE
https://t.co/clTUy2Mjv1
RT @DavidRoweWTL: "Conclusions: Patients with type 2 diabetes initiated with metformin monotherapy had longer survival than did matched, n…
"Conclusions: Patients with type 2 diabetes initiated with metformin monotherapy had longer survival than did matched, non-diabetic controls." {From a total censored follow-up period of 503,384 years.} (Big Study). https://t.co/Mjh92gnWPT
@RealCandaceO I’m loving Shot in the Dark and I’m wondering what do you think about Metformin? I watched this video on it: https://t.co/x1gQfjuVTO
RT @AlexSamTG: La publi décrite dans le docu, c'est celle-ci : https://t.co/dTSEtaJ2C2 Elle a pratiqué un ajustement pour atteindre non pas…
@Outdoctrination
https://t.co/Yrz9HH1YGD https://t.co/Y8qLRnXQL2
@AMCGME11 @DrAlkhodairy في الحقيقة مرضى السكر من النوع الثاني الذين يأخذون جلوكوفاج (ميتفورمين) يعيشون حياة صحية مثل أو أطول من غير المصابين بالسكر. ألمصدر: https://t.co/45LTS9zfph
RT @DrBDrugDoc: Type 2 Diabetics taking Metformin lived longer than those who were not T2D. https://t.co/6R1PdWcqCO
@ElieJarrougeMD I found this study incredible. T2D taking Metformin lived longer than those who were not T2D. https://t.co/6R1PdWcqCO
Type 2 Diabetics taking Metformin lived longer than those who were not T2D. https://t.co/6R1PdWcqCO
Hacking the 3 Pathways of Aging https://t.co/SIOH8ztLfQ via @YouTube
RT @BradStanfieldMD: References: https://t.co/XsVPJGFAbp https://t.co/CsSaw7YzQY https://t.co/PnWNp9Z4vC https://t.co/vFVUftHdtj https://t.…
RT @BradStanfieldMD: References: https://t.co/XsVPJGFAbp https://t.co/CsSaw7YzQY https://t.co/PnWNp9Z4vC https://t.co/vFVUftHdtj https://t.…
RT @BradStanfieldMD: References: https://t.co/XsVPJGFAbp https://t.co/CsSaw7YzQY https://t.co/PnWNp9Z4vC https://t.co/vFVUftHdtj https://t.…
References: https://t.co/XsVPJGFAbp https://t.co/CsSaw7YzQY https://t.co/PnWNp9Z4vC https://t.co/vFVUftHdtj https://t.co/Vc9y4ShTTD https://t.co/lfBKrHNAO4 https://t.co/HWl72VwLiQ https://t.co/1u1oIOJ0NR
RT @AlexSamTG: La publi décrite dans le docu, c'est celle-ci : https://t.co/dTSEtaJ2C2 Elle a pratiqué un ajustement pour atteindre non pas…
RT @AlexSamTG: La publi décrite dans le docu, c'est celle-ci : https://t.co/dTSEtaJ2C2 Elle a pratiqué un ajustement pour atteindre non pas…
La publi décrite dans le docu, c'est celle-ci : https://t.co/dTSEtaJ2C2 Elle a pratiqué un ajustement pour atteindre non pas "17%" mais "15%", et c'est pas super fiable pour plein de limitations évoquées... Résultats contredits ici : https://t.co/Y0k49un93U ⬇️ https://t.co/X4Wweuz6u3
I love Cleo Abram's idea of genuine optimism. In a world (specially on Twitter) where I see a lot of pessimism, this way of looking at technology brings fresh air. https://t.co/zn4koQqyWt
https://t.co/y0ga5qu7QG
@CJ_NFA @Openskies13 @DoctorJack16 I started to read about https://t.co/7gbDiA7A5k
https://t.co/E5Unq81u3E
RT @JBlivik: Reduction of high insulin (increases linearly with obesity & exposure to diabetes care) prolongs life, halves the risk of dyin…
Reduction of high insulin (increases linearly with obesity & exposure to diabetes care) prolongs life, halves the risk of dying, & helps with weight loss (along with physical activity immediately after eating, reduced intake of animal fat & fast carbs). https://t.co/ZeNC7IleGA
@llamacorn888 @VitalikButerin https://t.co/cTgEE6vc0B diabetics taking metformin live longer than healthy non-diabetics not taking it apparently
RT @docmaltese: Can people with type 2 diabetes live longer than those without? “Patients with type 2 diabetes initiated with metformin mo…
@CharlesMBrenner https://t.co/VN6ibzEpKv. https://t.co/vmbdCFyeCN
Correlation or Causation? Is Metformin, the big new "anti-aging" or rather prevent effects of aging drug? https://t.co/URIGg94oWo via @YouTube
@hankgreen @cleoabram My fave one recently: https://t.co/s45r8khsSp
@ilyassahinMD https://t.co/YW8co5YPx2 Sayın İlyas hocam, bazen benim de kullanasım gelmiyor değil.
Metformin i inne leki (potencjalnie!) opóźniające starzenie się.
Liked on YouTube: Metformin, the big new "anti-aging" drug, explained https://t.co/Ni5czf2rLE
Metformin, the big new "anti-aging" drug, explained https://t.co/qou0XJ0eEZ via @YouTube
Metformin, the big new "anti-aging" drug, explained https://t.co/mCMkqn6EHr via @YouTube
¿Y si un fármaco barato, conocido desde hace años para tratar la diabetes pudiera retrasar nuestro envejecimiento? Más importante aún : ¿Y si nos permitiera pasar más tiempo con los que más queremos? https://t.co/MvLWnM5JvA vía @cleoabram
The new way billionaires try to live longer https://t.co/xaXlfuPxMX via @YouTube
The new way billionaires try to live longer (@cleoabram) https://t.co/4hG5hXLzNH
The new way #billionaires try to live longer https://t.co/tr2biBmlH2 via @YouTube
RT @cleoabram: To try to live longer, billionaires are taking a pill that costs pennies. So, uh… does it work?
RT @cleoabram: To try to live longer, billionaires are taking a pill that costs pennies. So, uh… does it work?
The mainstream finally catching up to what @JayCampbell333 has been saying for years https://t.co/qV1JG6aWxa
RT @cleoabram: To try to live longer, billionaires are taking a pill that costs pennies. So, uh… does it work?
The new way billionaires try to live longer https://t.co/vJC5Nmhcu4 via @YouTube
Great video by @cleoabram to end the week https://t.co/WPUFJOIZW9
RT @cleoabram: To try to live longer, billionaires are taking a pill that costs pennies. So, uh… does it work?
The cheap drug rich people take to live longer https://t.co/P5U081zfdo
RT @cleoabram: To try to live longer, billionaires are taking a pill that costs pennies. So, uh… does it work?
RT @cleoabram: To try to live longer, billionaires are taking a pill that costs pennies. So, uh… does it work?
RT @cleoabram: To try to live longer, billionaires are taking a pill that costs pennies. So, uh… does it work?
@JEverettLearned https://t.co/Lq9sfhBHEC
RT @cleoabram: To try to live longer, billionaires are taking a pill that costs pennies. So, uh… does it work?
RT @cleoabram: To try to live longer, billionaires are taking a pill that costs pennies. So, uh… does it work?
RT @statto: Entertained to see that I got a (very tiny!) cameo in @cleoabram’s new video on anti-aging drug metformin! And it’s a great vi…
RT @statto: Entertained to see that I got a (very tiny!) cameo in @cleoabram’s new video on anti-aging drug metformin! And it’s a great vi…
Entertained to see that I got a (very tiny!) cameo in @cleoabram’s new video on anti-aging drug metformin! And it’s a great video whose conclusion I completely agree with. I get asked about metformin all the time and this is basically what I say: https://t.co/SAsrIxuueb
RT @cleoabram: To try to live longer, billionaires are taking a pill that costs pennies. So, uh… does it work?
RT @cleoabram: To try to live longer, billionaires are taking a pill that costs pennies. So, uh… does it work?
There is some evidence that metformin helps do this in people with diabetes. In the video, we walk through the study that got Dr. Barzilai interested. BUT it's not clear that the whole "dying less" thing applies equally to people without diabetes. https://t.co/QMVEDN6PjB
To try to live longer, billionaires are taking a pill that costs pennies. So, uh… does it work?
https://t.co/nUu0AVdwUv ①糖尿病患者でメタホルン摂取グループ VS ②糖尿病でなく、メタホルンも摂取していないグループ ②のグループは糖尿病でないにもかかわらず、ライフスパン(寿命)は①のグループに比べて15%も短かった https://t.co/cXv4QXo0gS
Hacking the 3 Pathways of Aging https://t.co/6TL8fLPafi via @YouTube
@naplesdave I know taking meds is a pain but there is some interest atm about met having some healthful effects other than BGL control. I have attached the Bannister paper. And the study currently looking at understanding what is going on - the TAME study.https://t.co/kVmwWHdZOC
Hacking the 3 Pathways of Aging https://t.co/kWbfo5OujD via @YouTube
RT @Daniilgor: This study (published 6 years ago) strongly suggested that metformin prolongs lives. No one gave a damn. But with #COVIDー19,…
This study (published 6 years ago) strongly suggested that metformin prolongs lives. No one gave a damn. But with #COVIDー19, saving the elderly suddenly became a religion. Politics is fundamentally irrational. https://t.co/BpTt3HOaG3
@drjkahn @davidasinclair Thanks for the interesting research. Mic has these notes to consider: https://t.co/ESmB4nqDJU (Includes some vegetables that naturally contain NMN).
https://t.co/2lH3NvvNWq
@HanCardiomd @DBelardoMD Here's the study: https://t.co/SMbbRGfCRC
@und3rgrounder @DBelardoMD "Patients with type 2 diabetes initiated with metformin monotherapy had longer survival than did matched, non-diabetic controls. Those treated with sulphonylurea had markedly reduced survival" https://t.co/SMbbRGfCRC
@DBelardoMD @SteveH35081752 "Patients with T2D initiated with metformin monotherapy had longer survival than did matched, non-diabetic controls. Those treated with sulphonylurea had markedly reduced survival compared with both matched controls and....." https://t.co/SMbbRGfCRC
Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non‐diabetic controls https://t.co/2acmvx2SUr
Hacking the 3 Pathways of Aging https://t.co/bpOcwN0M4f
Hacking the 3 Pathways of Aging https://t.co/WtyopJoBGb via @YouTube
@bigpurpleduck @TheRhodri Metformin might help you with smoothing out the IR due to hormone stuff. It is relatively cheap and has been around for about 60 years. Also may have other protective benefits ?? (see Bannister study 2014 https://t.co/Bi6f4elpLR or TAME studyl currently going on).
Ska metformin skrivas ut till äldre utan diabetes typ 2? https://t.co/7UxfMlKaf0
@StevenSalzberg1 @EverydayFinance There is very limited evidence in diabetics, leading to efforts to study it in adults without diabetes. https://t.co/DxqBPmkfwT
A