Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls.
C A Bannister, S E Holden, S Jenkins-Jones, C Ll Morgan, J P Halcox, G Schernthaner, J Mukherjee, C J Currie
November 2014 Diabetes Obes MetabSynopsis of Social media discussions
Discussions reveal a strong interest in the possibility that metformin could extend lifespan, exemplified by users mentioning specific studies like Bannister et al. (2014) and the TAME trial, and expressing curiosity about its broader health effects, with a tone that balances skepticism and optimism that signals meaningful engagement and recognition of impact.
Agreement
Moderate agreementMost discussions support the idea that metformin may promote longevity, referencing studies like Bannister et al. (2014) and the TAME trial, though some express skepticism about the extrapolation to non-diabetics.
Interest
High level of interestPosts show high curiosity, with many referencing videos explaining metformin's potential, and users actively engaging with study details and implications.
Engagement
High engagementParticipants analyze the study's findings, question causation versus correlation, and discuss potential benefits beyond diabetes management, indicating deep engagement.
Impact
Moderate level of impactWhile some see the findings as potentially transformative, especially given the cost-effectiveness of the drug, others remain cautious, reflecting moderate perceived impact before definitive proof.
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Posts referencing the article
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Exploring Anti-Aging Drugs and Lifespan Extension Studies
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Metformin and Sulphonylurea Impact on Mortality and Longevity
The study investigates whether increased cardiovascular risk and mortality in diabetes patients are due to sulphonylureas or benefits of metformin. Data shows metformin users have better survival rates than non-diabetics, while sulphonylurea users have reduced survival. Learn more about these effects.
Metformin's Impact on Longevity in Type 2 Diabetes Patients
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youtu.be/sFbghkE0WYo?... This is one of the cheapest and most effective drugs on Earth but of course there is no magic pill.
view full postAugust 21, 2025
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Chuck Frasher
@ChuckFrasher (Twitter)@davidasinclair David Sinclair https://t.co/vmbdCFyeCN https://t.co/VN6ibzEpKv https://t.co/U0BkU1irZP https://t.co/44NfnvGi3Z https://t.co/Jp5fOjhBcb https://t.co/XjhwQ2ELzi https://t.co/eZ8m3IO72D
view full postJuly 18, 2025
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Chuck Frasher
@ChuckFrasher (Twitter)@siimland @davidasinclair https://t.co/vmbdCFyeCN https://t.co/VN6ibzEpKv https://t.co/U0BkU1irZP https://t.co/44NfnvGi3Z https://t.co/Jp5fOjhBcb https://t.co/XjhwQ2ELzi https://t.co/eZ8m3IO72D
view full postJuly 18, 2025
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Hopehood.org
@dotails (Twitter)## Immortality Theater Nobody knows what works best for your body, but we can't let anything keep us from trying our best. Here's some ideas about health I've found. https://t.co/abmxIr13f4
view full postMay 22, 2025
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ᯅ
@teel0ck (Twitter)Metformin, the Big New "Anti-Aging" Drug, Explained https://t.co/Ik5kcNlqRw via @YouTube
view full postApril 30, 2025
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赤い炊飯ジャー(shin1_s)
@shin1_s (Twitter)Can people with type 2 diabetes live longer than those without? https://t.co/ljTM5jyM0A
view full postApril 21, 2025
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waz
@_waztra (Twitter)https://t.co/eiY0ued5YL
view full postJanuary 8, 2025
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Hopehood.org
@dotails (Twitter)## Immortality Theater Nobody knows what works best for your body, but we can't let anything keep us from trying our best. Here's some ideas about health I've found. https://t.co/abmxIr13f4
view full postOctober 24, 2024
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luis hernan graffe
@hernangraffe (Twitter)https://t.co/PvVTXOFPUC
view full postOctober 22, 2024
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Health on a Budget
@healthonabudget (Twitter)Is metformin the new anti-aging drug? https://t.co/1wpnf7YCna
view full postOctober 20, 2024
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DANVZLA
@danvzla (Twitter)Metformin, the Big New "Anti-Aging" Drug, Explained https://t.co/VBaiykRYRE via @YouTube
view full postOctober 3, 2024
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Brian Goodman
@BrianGo11111623 (Twitter)https://t.co/Kcbzik6jVG
view full postSeptember 16, 2024
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BillOckham
@BillOccham0 (Twitter)@Madam_Mito That’s NOT a trial but observational data 2nd It’s not true as shown here: https://t.co/UDMtnSbSge And least but MOST important - plenty of life extended signalling paths https://t.co/EiJaxjqooA
view full postSeptember 13, 2024
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Hopehood.org
@dotails (Twitter)## Immortality Theater Nobody knows what works best for your body, but we can't let anything keep us from trying our best. Here's some ideas about health I've found. https://t.co/abmxIr13f4
view full postJuly 18, 2024
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luis hernan graffe
@hernangraffe (Twitter)https://t.co/EyIRVweOq1
view full postJune 7, 2024
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Jordan Curl
@JordanCurlMD (Twitter)TAME Trial https://t.co/AfsfwUflKc Keys et al. (2022) https://t.co/9qy2Lhqvvw Bannister et al. (2014) https://t.co/GPw4bEfasD
view full postMay 21, 2024
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Pee Baa
@Pee_Baaa (Twitter)@OkieLibSherry @EvolaVonValor @_celia_bedelia_ I guess type 2 diabetes must be healthy since they live longer if on metformin than no diabetics lol. Jfc it’s almost like medical interventions work lol.
view full postDecember 24, 2023
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Mind Your Science!
@MindYourSci (Twitter)RT @agingdoc1: Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin…
view full postDecember 15, 2023
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frank
@frankwikson (Twitter)RT @agingdoc1: Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin…
view full postDecember 14, 2023
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Agingdoc
@agingdoc1 (Twitter)Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls (2014) https://t.co/wu0eCQfOIr
view full postDecember 14, 2023
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Yuji Marutani Planning Director
@YujiMarutani (Twitter)Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non‐diabetic controls - Bannister - 2014 - Diabetes, Obesity and Metabolism - Wiley https://t.co/8SeCyQOHDE
view full postDecember 6, 2023
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alinthemind
@alinthemind (Twitter)https://t.co/clTUy2Mjv1
view full postNovember 29, 2023
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Alessiana
@Alessiana (Twitter)RT @DavidRoweWTL: "Conclusions: Patients with type 2 diabetes initiated with metformin monotherapy had longer survival than did matched, n…
view full postSeptember 11, 2023
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DavidRowe ⧖ - Caution, you may encounter nuance.
@DavidRoweWTL (Twitter)"Conclusions: Patients with type 2 diabetes initiated with metformin monotherapy had longer survival than did matched, non-diabetic controls." {From a total censored follow-up period of 503,384 years.} (Big Study). https://t.co/Mjh92gnWPT
view full postSeptember 11, 2023
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ParshPolit
@ParshPolit (Twitter)@RealCandaceO I’m loving Shot in the Dark and I’m wondering what do you think about Metformin? I watched this video on it: https://t.co/x1gQfjuVTO
view full postJuly 5, 2023
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VAUBAN Sébastien Le Prestre
@Vauban059 (Twitter)RT @AlexSamTG: La publi décrite dans le docu, c'est celle-ci : https://t.co/dTSEtaJ2C2 Elle a pratiqué un ajustement pour atteindre non pas…
view full postJune 1, 2023
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Sixers
@sixers2772 (Twitter)@Outdoctrination
view full postMay 23, 2023
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Laszlo Levay Trump best president
@levis3331 (Twitter)https://t.co/Yrz9HH1YGD https://t.co/Y8qLRnXQL2
view full postMay 15, 2023
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Esam Shahlol, MD
@EsamShahlol (Twitter)@AMCGME11 @DrAlkhodairy في الحقيقة مرضى السكر من النوع الثاني الذين يأخذون جلوكوفاج (ميتفورمين) يعيشون حياة صحية مثل أو أطول من غير المصابين بالسكر. ألمصدر: https://t.co/45LTS9zfph
view full postFebruary 24, 2023
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Genetic Health Systems
@GeneHealthSys (Twitter)RT @DrBDrugDoc: Type 2 Diabetics taking Metformin lived longer than those who were not T2D. https://t.co/6R1PdWcqCO
view full postFebruary 20, 2023
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Brad Carper
@BradPharm (Twitter)@ElieJarrougeMD I found this study incredible. T2D taking Metformin lived longer than those who were not T2D. https://t.co/6R1PdWcqCO
view full postFebruary 20, 2023
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Brad Carper
@BradPharm (Twitter)Type 2 Diabetics taking Metformin lived longer than those who were not T2D. https://t.co/6R1PdWcqCO
view full postFebruary 20, 2023
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@HemskVampyr (Twitter)Hacking the 3 Pathways of Aging https://t.co/SIOH8ztLfQ via @YouTube
view full postFebruary 20, 2023
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luis hernan graffe
@hernangraffe (Twitter)RT @BradStanfieldMD: References: https://t.co/XsVPJGFAbp https://t.co/CsSaw7YzQY https://t.co/PnWNp9Z4vC https://t.co/vFVUftHdtj https://t.…
view full postJanuary 30, 2023
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Sonia Jardón V
@sjardon_gdl (Twitter)RT @BradStanfieldMD: References: https://t.co/XsVPJGFAbp https://t.co/CsSaw7YzQY https://t.co/PnWNp9Z4vC https://t.co/vFVUftHdtj https://t.…
view full postJanuary 12, 2023
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John Best
@noobestjohn (Twitter)RT @BradStanfieldMD: References: https://t.co/XsVPJGFAbp https://t.co/CsSaw7YzQY https://t.co/PnWNp9Z4vC https://t.co/vFVUftHdtj https://t.…
view full postJanuary 12, 2023
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Dr Brad Stanfield
@BradStanfieldMD (Twitter)References: https://t.co/XsVPJGFAbp https://t.co/CsSaw7YzQY https://t.co/PnWNp9Z4vC https://t.co/vFVUftHdtj https://t.co/Vc9y4ShTTD https://t.co/lfBKrHNAO4 https://t.co/HWl72VwLiQ https://t.co/1u1oIOJ0NR
view full postJanuary 12, 2023
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Peekaboo
@PaPeekaboo (Twitter)RT @AlexSamTG: La publi décrite dans le docu, c'est celle-ci : https://t.co/dTSEtaJ2C2 Elle a pratiqué un ajustement pour atteindre non pas…
view full postDecember 17, 2022
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Aude Smith
@AudeSmith5 (Twitter)RT @AlexSamTG: La publi décrite dans le docu, c'est celle-ci : https://t.co/dTSEtaJ2C2 Elle a pratiqué un ajustement pour atteindre non pas…
view full postDecember 17, 2022
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Alexander Samuel
@AlexSamTG (Twitter)La publi décrite dans le docu, c'est celle-ci : https://t.co/dTSEtaJ2C2 Elle a pratiqué un ajustement pour atteindre non pas "17%" mais "15%", et c'est pas super fiable pour plein de limitations évoquées... Résultats contredits ici : https://t.co/Y0k49un93U ⬇️ https://t.co/X4Wweuz6u3
view full postDecember 17, 2022
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David Stănete
@stanete (Twitter)I love Cleo Abram's idea of genuine optimism. In a world (specially on Twitter) where I see a lot of pessimism, this way of looking at technology brings fresh air. https://t.co/zn4koQqyWt
view full postDecember 13, 2022
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goufpeera
@goufpeera2 (Twitter)https://t.co/y0ga5qu7QG
view full postNovember 22, 2022
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@kedarus (Twitter)@CJ_NFA @Openskies13 @DoctorJack16 I started to read about https://t.co/7gbDiA7A5k
view full postOctober 17, 2022
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BATMAN
@ChamaraVFX (Twitter)https://t.co/E5Unq81u3E
view full postOctober 7, 2022
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@Orlando_uy (Twitter)RT @JBlivik: Reduction of high insulin (increases linearly with obesity & exposure to diabetes care) prolongs life, halves the risk of dyin…
view full postJuly 13, 2022
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John Blivik
@JBlivik (Twitter)Reduction of high insulin (increases linearly with obesity & exposure to diabetes care) prolongs life, halves the risk of dying, & helps with weight loss (along with physical activity immediately after eating, reduced intake of animal fat & fast carbs). https://t.co/ZeNC7IleGA
view full postJuly 13, 2022
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a
@nhxpost (Twitter)@llamacorn888 @VitalikButerin https://t.co/cTgEE6vc0B diabetics taking metformin live longer than healthy non-diabetics not taking it apparently
view full postJune 20, 2022
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Giuseppe Maltese
@docmaltese (Twitter)RT @docmaltese: Can people with type 2 diabetes live longer than those without? “Patients with type 2 diabetes initiated with metformin mo…
view full postMay 3, 2022
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Chuck Frasher
@ChuckFrasher (Twitter)@CharlesMBrenner https://t.co/VN6ibzEpKv. https://t.co/vmbdCFyeCN
view full postMay 1, 2022
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Prajit
@docprajit (Twitter)Correlation or Causation? Is Metformin, the big new "anti-aging" or rather prevent effects of aging drug? https://t.co/URIGg94oWo via @YouTube
view full postApril 24, 2022
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Annie
@fullinhalfout (Twitter)@hankgreen @cleoabram My fave one recently: https://t.co/s45r8khsSp
view full postApril 12, 2022
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ShibaTatsuya
@ShibaTa50325300 (Twitter)@ilyassahinMD https://t.co/YW8co5YPx2 Sayın İlyas hocam, bazen benim de kullanasım gelmiyor değil.
view full postApril 6, 2022
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Tomasz
@perlyswietlne (Twitter)Metformin i inne leki (potencjalnie!) opóźniające starzenie się.
view full postApril 3, 2022
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Philosophy And Math
@philosophy_math (Twitter)Liked on YouTube: Metformin, the big new "anti-aging" drug, explained https://t.co/Ni5czf2rLE
view full postApril 3, 2022
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曾嘉俊 Zeng Jiajun
@zengjiajun_eth (Twitter)Metformin, the big new "anti-aging" drug, explained https://t.co/qou0XJ0eEZ via @YouTube
view full postMarch 21, 2022
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ProjectOneWorldLearn
@OneWorldSchool1 (Twitter)Metformin, the big new "anti-aging" drug, explained https://t.co/mCMkqn6EHr via @YouTube
view full postMarch 21, 2022
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Pelayo Prieto
@PelayoPrieto (Twitter)¿Y si un fármaco barato, conocido desde hace años para tratar la diabetes pudiera retrasar nuestro envejecimiento? Más importante aún : ¿Y si nos permitiera pasar más tiempo con los que más queremos? https://t.co/MvLWnM5JvA vía @cleoabram
view full postMarch 15, 2022
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SortaRican
@vaughnp (Twitter)The new way billionaires try to live longer https://t.co/xaXlfuPxMX via @YouTube
view full postFebruary 5, 2022
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MediaREDEF
@MediaREDEF (Twitter)The new way billionaires try to live longer (@cleoabram) https://t.co/4hG5hXLzNH
view full postFebruary 4, 2022
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ᯅ
@teel0ck (Twitter)The new way #billionaires try to live longer https://t.co/tr2biBmlH2 via @YouTube
view full postFebruary 4, 2022
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Sachin Mourya
@SachinMourya6 (Twitter)RT @cleoabram: To try to live longer, billionaires are taking a pill that costs pennies. So, uh… does it work?
view full postFebruary 4, 2022
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How to Change Your Self
@iamdeandwyer (Twitter)RT @cleoabram: To try to live longer, billionaires are taking a pill that costs pennies. So, uh… does it work?
view full postFebruary 4, 2022
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Show Me Strength
@ShowMeStrength (Twitter)The mainstream finally catching up to what @JayCampbell333 has been saying for years https://t.co/qV1JG6aWxa
view full postFebruary 4, 2022
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HouseOfOchii
@OchiiOgango (Twitter)RT @cleoabram: To try to live longer, billionaires are taking a pill that costs pennies. So, uh… does it work?
view full postFebruary 4, 2022
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Abhishek Patil
@oldtrafford007 (Twitter)The new way billionaires try to live longer https://t.co/vJC5Nmhcu4 via @YouTube
view full postFebruary 4, 2022
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wachira
@__wchr (Twitter)Great video by @cleoabram to end the week https://t.co/WPUFJOIZW9
view full postFebruary 4, 2022
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RiskReversal Media
@RiskReversal (Twitter)RT @cleoabram: To try to live longer, billionaires are taking a pill that costs pennies. So, uh… does it work?
view full postFebruary 3, 2022
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ricardosharing
@ricardosharing (Twitter)The cheap drug rich people take to live longer https://t.co/P5U081zfdo
view full postFebruary 2, 2022
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Nestor Lagos Borda
@DxNESTORxD (Twitter)RT @cleoabram: To try to live longer, billionaires are taking a pill that costs pennies. So, uh… does it work?
view full postFebruary 2, 2022
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Rob Schutz
@rob (Twitter)RT @cleoabram: To try to live longer, billionaires are taking a pill that costs pennies. So, uh… does it work?
view full postFebruary 1, 2022
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Z Reitano
@ZReitano (Twitter)RT @cleoabram: To try to live longer, billionaires are taking a pill that costs pennies. So, uh… does it work?
view full postFebruary 1, 2022
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ntapia
@ntapia (Twitter)@JEverettLearned https://t.co/Lq9sfhBHEC
view full postFebruary 1, 2022
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Louis Anslow
@LouisAnslow (Twitter)RT @cleoabram: To try to live longer, billionaires are taking a pill that costs pennies. So, uh… does it work?
view full postFebruary 1, 2022
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Garry Tan
@garrytan (Twitter)RT @cleoabram: To try to live longer, billionaires are taking a pill that costs pennies. So, uh… does it work?
view full postFebruary 1, 2022
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Louis Anslow
@LouisAnslow (Twitter)RT @statto: Entertained to see that I got a (very tiny!) cameo in @cleoabram’s new video on anti-aging drug metformin! And it’s a great vi…
view full postFebruary 1, 2022
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Cleo Abram
@cleoabram (Twitter)RT @statto: Entertained to see that I got a (very tiny!) cameo in @cleoabram’s new video on anti-aging drug metformin! And it’s a great vi…
view full postFebruary 1, 2022
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Andrew Steele
@statto (Twitter)Entertained to see that I got a (very tiny!) cameo in @cleoabram’s new video on anti-aging drug metformin! And it’s a great video whose conclusion I completely agree with. I get asked about metformin all the time and this is basically what I say: https://t.co/SAsrIxuueb
view full postFebruary 1, 2022
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Nicholas (Sedgewick) Thompson
@niksthompson (Twitter)RT @cleoabram: To try to live longer, billionaires are taking a pill that costs pennies. So, uh… does it work?
view full postFebruary 1, 2022
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JULES
@julesterpak (Twitter)RT @cleoabram: To try to live longer, billionaires are taking a pill that costs pennies. So, uh… does it work?
view full postFebruary 1, 2022
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Cleo Abram
@cleoabram (Twitter)There is some evidence that metformin helps do this in people with diabetes. In the video, we walk through the study that got Dr. Barzilai interested. BUT it's not clear that the whole "dying less" thing applies equally to people without diabetes. https://t.co/QMVEDN6PjB
view full postFebruary 1, 2022
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Cleo Abram
@cleoabram (Twitter)To try to live longer, billionaires are taking a pill that costs pennies. So, uh… does it work?
view full postFebruary 1, 2022
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TY (タイ)
@150made (Twitter)https://t.co/nUu0AVdwUv ①糖尿病患者でメタホルン摂取グループ VS ②糖尿病でなく、メタホルンも摂取していないグループ ②のグループは糖尿病でないにもかかわらず、ライフスパン(寿命)は①のグループに比べて15%も短かった https://t.co/cXv4QXo0gS
view full postJuly 14, 2021
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Paul Benavidez
@paulmbenavidez (Twitter)Hacking the 3 Pathways of Aging https://t.co/6TL8fLPafi via @YouTube
view full postJuly 7, 2021
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lisa champion
@lm_champion (Twitter)@naplesdave I know taking meds is a pain but there is some interest atm about met having some healthful effects other than BGL control. I have attached the Bannister paper. And the study currently looking at understanding what is going on - the TAME study.https://t.co/kVmwWHdZOC
view full postJune 2, 2021
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DaRocDok.com®
@DaRocDok (Twitter)Hacking the 3 Pathways of Aging https://t.co/kWbfo5OujD via @YouTube
view full postApril 24, 2021
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Rohit Gupta
@rohit_bmw (Twitter)RT @Daniilgor: This study (published 6 years ago) strongly suggested that metformin prolongs lives. No one gave a damn. But with #COVIDー19,…
view full postDecember 29, 2020
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Daniil Gorbatenko
@Daniilgor (Twitter)This study (published 6 years ago) strongly suggested that metformin prolongs lives. No one gave a damn. But with #COVIDー19, saving the elderly suddenly became a religion. Politics is fundamentally irrational. https://t.co/BpTt3HOaG3
view full postDecember 28, 2020
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Bruno.N
@BrunoN29428943 (Twitter)@drjkahn @davidasinclair Thanks for the interesting research. Mic has these notes to consider: https://t.co/ESmB4nqDJU (Includes some vegetables that naturally contain NMN).
view full postDecember 6, 2020
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Republican-Justicialist (He/Him/The God Of F*ck)
@JRClark14591150 (Twitter)https://t.co/2lH3NvvNWq
view full postSeptember 8, 2020
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Matthew Lake
@Matthew_Lake182 (Twitter)@HanCardiomd @DBelardoMD Here's the study: https://t.co/SMbbRGfCRC
view full postAugust 27, 2020
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Matthew Lake
@Matthew_Lake182 (Twitter)@und3rgrounder @DBelardoMD "Patients with type 2 diabetes initiated with metformin monotherapy had longer survival than did matched, non-diabetic controls. Those treated with sulphonylurea had markedly reduced survival" https://t.co/SMbbRGfCRC
view full postAugust 27, 2020
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Matthew Lake
@Matthew_Lake182 (Twitter)@DBelardoMD @SteveH35081752 "Patients with T2D initiated with metformin monotherapy had longer survival than did matched, non-diabetic controls. Those treated with sulphonylurea had markedly reduced survival compared with both matched controls and....." https://t.co/SMbbRGfCRC
view full postAugust 27, 2020
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د هيثم السيف
@57ksu (Twitter)Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non‐diabetic controls https://t.co/2acmvx2SUr
view full postJuly 27, 2020
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ᵀᵒⁿᵉ
@ToneLives (Twitter)Hacking the 3 Pathways of Aging https://t.co/bpOcwN0M4f
view full postJuly 25, 2020
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~Journey P.Ⓥ︎
@SouLJOo0oOurney (Twitter)Hacking the 3 Pathways of Aging https://t.co/WtyopJoBGb via @YouTube
view full postJuly 24, 2020
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lisa champion
@lm_champion (Twitter)@bigpurpleduck @TheRhodri Metformin might help you with smoothing out the IR due to hormone stuff. It is relatively cheap and has been around for about 60 years. Also may have other protective benefits ?? (see Bannister study 2014 https://t.co/Bi6f4elpLR or TAME studyl currently going on).
view full postJuly 2, 2020
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Staffan
@StaffanOlsson13 (Twitter)Ska metformin skrivas ut till äldre utan diabetes typ 2? https://t.co/7UxfMlKaf0
view full postFebruary 29, 2020
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Matt Baggott
@mattbagg (Twitter)@StevenSalzberg1 @EverydayFinance There is very limited evidence in diabetics, leading to efforts to study it in adults without diabetes. https://t.co/DxqBPmkfwT
view full postSeptember 17, 2019
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Abstract Synopsis
- The study aimed to determine whether increased cardiovascular risk and mortality in diabetes patients was due to harmful effects of sulphonylureas or beneficial effects of metformin by comparing all-cause mortality in patients treated with either drug.
- Researchers analyzed data from the UK Clinical Practice Research Datalink, comparing 78,241 patients on metformin, 12,222 on sulphonylureas, and 90,463 matched non-diabetic individuals over a total follow-up period of 503,384 years.
- Findings indicated that patients on metformin had better survival rates than matched non-diabetic controls, while those on sulphonylureas faced a significant reduction in survival compared to both metformin patients and non-diabetic individuals.
Adam Galas
@adamgalas.bsky.social (Bluesky)