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Nature August 2014 PMID 25043035

Altitude adaptation in Tibetans caused by introgression of Denisovan-like DNA.

Emilia Huerta-Sánchez, Xin Jin, Asan, Zhuoma Bianba, Benjamin M Peter, Nicolas Vinckenbosch, Yu Liang, Xin Yi, Mingze He, Mehmet Somel, Peixiang Ni, Bo Wang, Xiaohua Ou, Huasang, Jiangbai Luosang

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192
Peak: 2 in Jul 2014
across 7 sources since Jul 2014

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AI synopsis

What people are saying

The discussions reflect a positive attitude towards the study, with comments like 'kudos to Emilia' and references to the genetic basis of altitude adaptation, such as the Denisovan gene. The tone is enthusiastic and respectful, emphasizing the scientific importance and novelty of the findings.

AgreementModerate agreement

Most discussions acknowledge and support the findings of the research, highlighting its significance.

InterestModerate interest

Participants show moderate curiosity, engaging with the subject of human adaptation and genetic introgression.

EngagementModerate engagement

Comments demonstrate active engagement, such as recognizing researchers and summarizing genetic concepts.

ImpactModerate impact

The discussions suggest that the publication is considered impactful, advancing understanding of human evolution and adaptation.

Abstract in brief

  • Tibetans have adapted to high-altitude environments through a genetic change in the EPAS1 gene, which influences oxygen levels in the blood, and this adaptation is linked to introgression from Denisovan-like DNA.
  • The unusual genetic haplotype found in Tibetans matches that of Denisovans and is rare in other modern populations, suggesting that it was acquired through interbreeding (introgression) rather than inherited from a common ancestor.
  • This study shows that interbreeding with extinct human relatives like Denisovans has contributed to beneficial genetic traits that help modern humans survive in challenging environments such as high altitudes.]
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Most liked on X and Bluesky
Agus BAC
@ElAgusdeKomodo · X

For Chp 4 Mutation we have @emiliahsc's "Altitude adaptation in Tibetans caused by introgression of Denisovan-like DNA" https://t.co/4AVr34rNTy and also Cinthya Beall's "Detecting natural selection in high-altitude human populations" https://t.co/epiejZxCoI #EvolutionisFemale 3/n

Jun 3, 2020 · 4 likes · 3,156 followers View post →
DeanxRiley
@DeanxRiley · X

@bronzeagemantis #69 surface area of skin is square of length, volume is cube. Polar animals are larger so less heat loss. Lithe desert features allow for greater heat loss. Tibetan altitude adaptation was selective sweep of Denisovan gene https://t.co/OkyPZo5ej1

Jun 1, 2024 · 2,453 followers View post →
Katerina
@Jerichon_kat · X

https://t.co/hBXveVCNun

Dec 18, 2021 · 134 followers View post →
Paleogenomics - María Ávila Arcos
@paleogenomics.bsky.social · Bluesky

Excited 2 see this out! kudos 2 Emilia! Altitude adaptation in Tibetans caused by introgression of Denisovan-like DNA http://go.nature.com/GRWpo6

Jul 2, 2014 View post →

All mentions

Denisovans: Understanding Our Ancient Human Relatives

Denisovans are mysterious hominins whose traces live on in modern humans. This video explores their significant role in human evolution, including their impact in regions like Indonesia. Discover how Denisovans may…

Evolucy · Jul 14, 2025 215 views
DeanxRiley
@DeanxRiley · X

@bronzeagemantis #69 surface area of skin is square of length, volume is cube. Polar animals are larger so less heat loss. Lithe desert features allow for greater heat loss. Tibetan altitude adaptation was selective sweep of Denisovan gene https://t.co/OkyPZo5ej1

Jun 1, 2024 · 2,453 followers View post →
Katerina
@Jerichon_kat · X

https://t.co/hBXveVCNun

Dec 18, 2021 · 134 followers View post →
Agus BAC
@ElAgusdeKomodo · X

For Chp 4 Mutation we have @emiliahsc's "Altitude adaptation in Tibetans caused by introgression of Denisovan-like DNA" https://t.co/4AVr34rNTy and also Cinthya Beall's "Detecting natural selection in high-altitude human populations" https://t.co/epiejZxCoI #EvolutionisFemale 3/n

Jun 3, 2020 · 4 likes · 3,156 followers View post →
Hannes Schroeder
@bitesizedna.bsky.social · Bluesky

Altitude adaptation in Tibetans caused by introgression of Denisovan-like DNA http://www.nature.com/nature/journal/vaop/ncurrent/full/nature13408.html?WT.ec_id=NATURE-20140703

Jul 2, 2014 View post →
Paleogenomics - María Ávila Arcos
@paleogenomics.bsky.social · Bluesky

Excited 2 see this out! kudos 2 Emilia! Altitude adaptation in Tibetans caused by introgression of Denisovan-like DNA http://go.nature.com/GRWpo6

Jul 2, 2014 View post →