Discussions highlight the core finding that 8.2% of the human genome is constrained, with some posts emphasizing the significance of conserved sequences, while others note the rapid evolution of noncoding regions. The tone balances curiosity with recognition of the study's importance, reflected in phrases like 'important for understanding' and 'a step forward in genetics research,' showing moderate but meaningful engagement and impact.
AgreementModerate agreement
Most discussions acknowledge the importance of the research, referencing the significance of constrained sequences in genome evolution.
InterestModerate interest
Participants show moderate curiosity, with comments inviting others to explore the research further, indicating genuine interest.
EngagementModerate engagement
They reference specific aspects of the paper, such as the percentage of the genome constrained and implications for understanding functional elements, demonstrating thoughtful engagement.
ImpactModerate impact
The posts suggest that the findings are seen as relevant and potentially influential for ongoing genetic research and understanding genome evolution.
Abstract in brief
Approximately 82% of the human genome is under negative selection, indicating it likely has functional importance.
Short-lived constrained sequences, especially in noncoding regions like regulatory sites, evolve rapidly and are not always detected by conservation-based models.
Protein-coding regions are highly stable over evolutionary time, with some sequences remaining conserved for over a billion years, while many other functional elements are more dynamic and species-specific.]
If you are interested, find here more on our research about constrained sequences in the human genome https://t.co/ELCG8PV3WA and antibiotic resistance genes in the genomes of integrated bacterial viruses https://t.co/3N1GvPwOpR #APDUpostdocday https://t.co/vTVFL0q617
Jun 6, 2019 · 5 likes · 2 shares · 467 followersView post →
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karlDerGroße
@AthameWerfer · X
@munecatmusic https://t.co/ybQymlXZzr
source in question
@halvorz for me the level of uncertainty in human genome or most mammal ones are of the sort of whether you trust more 7% something functional estimates or those that go as high as 10-15% https://t.co/f7cAHDpHv4
Oct 24, 2020 · 1 like · 6,266 followersView post →
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Galapagos Chuck
@Friendof_Darwin · X
@PatricktheB @SharkTooth787 @umfpt @DeanoMartino1 @odktiger @LeannEAF @ScientiaPercept @jools6691 @AndrewRChapman @IngridIngwah @Redsabr @tklforgiven @WastedAerospace @Canna420Uk @wpcguy @geraldpayne25 @SabeerAbdulla @Janetb172 @TheCOAPodcast @Unagami01 @AnthonyT2_Mufc @Jahvell13 @JaTapps @themuslimpolym1 @malo_j @ssss10901424 @brough_joshua @TheAzeriAkh @nature_enjoyer @TheRadMadLad1 @SouthernMoslem @alQawqazi1 @lawanbabor @Ah_Science @smkrdrsssns @myhighhills @againststrawmen @nadsshoes @michellmybell1 @PeterFi98279139 @Megavolt1 @Tanya_terrell1 @HaircutSpock @imkimaaron @JerryHelton14 @manchestermelly @TheWestonMike @PG13ScottWatson @htownsmitty @Aaron23582125 Two of the cited sources in his article are to pseudoscience websites. Here is the only legitimate source listed, and it doesn't help the YEC argument at all. https://t.co/gliAtOEch1
@CoelhoPre Sure:
Rands, Chris M., et al. “8.2% of the Human Genome Is Constrained: Variation in Rates of Turnover across Functional Element Classes in the Human Lineage.” PLOS Genetics, vol. 10, no. 7, July 2014, p. e1004525. PLoS Journals, doi:10.1371/journal.pgen.1004525.
@Senta233 @JaTapps @juddclyjohnson @CriticalCripple @JordivisionD @underdog1965 @SciencelsLife @custardsmaster “It is widely accepted that purifying selection persisting over long evolutionary times is a ubiquitous mode of evolution.”
https://t.co/KmsZlhWHPk
This video explains how mutations influence the fundamental theorem of natural selection, providing a more realistic view of evolution by incorporating mutational effects alongside genetic variance.
Discussion on creation and evolution, examining scientific papers that support biblical creation, emphasizing the functional importance and conservation of the human genome.
@PatricktheB @SharkTooth787 @umfpt @DeanoMartino1 @odktiger @LeannEAF @ScientiaPercept @jools6691 @AndrewRChapman @IngridIngwah @Redsabr @tklforgiven @WastedAerospace @Canna420Uk @wpcguy @geraldpayne25 @SabeerAbdulla @Janetb172 @TheCOAPodcast @Unagami01 @AnthonyT2_Mufc @Jahvell13 @JaTapps @themuslimpolym1 @malo_j @ssss10901424 @brough_joshua @TheAzeriAkh @nature_enjoyer @TheRadMadLad1 @SouthernMoslem @alQawqazi1 @lawanbabor @Ah_Science @smkrdrsssns @myhighhills @againststrawmen @nadsshoes @michellmybell1 @PeterFi98279139 @Megavolt1 @Tanya_terrell1 @HaircutSpock @imkimaaron @JerryHelton14 @manchestermelly @TheWestonMike @PG13ScottWatson @htownsmitty @Aaron23582125 Two of the cited sources in his article are to pseudoscience websites. Here is the only legitimate source listed, and it doesn't help the YEC argument at all. https://t.co/gliAtOEch1
@halvorz for me the level of uncertainty in human genome or most mammal ones are of the sort of whether you trust more 7% something functional estimates or those that go as high as 10-15% https://t.co/f7cAHDpHv4
Oct 24, 2020 · 1 like · 6,266 followersView post →
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Ben Sprung
@bgsprung · X
@CoelhoPre Sure:
Rands, Chris M., et al. “8.2% of the Human Genome Is Constrained: Variation in Rates of Turnover across Functional Element Classes in the Human Lineage.” PLOS Genetics, vol. 10, no. 7, July 2014, p. e1004525. PLoS Journals, doi:10.1371/journal.pgen.1004525.
If you are interested, find here more on our research about constrained sequences in the human genome https://t.co/ELCG8PV3WA and antibiotic resistance genes in the genomes of integrated bacterial viruses https://t.co/3N1GvPwOpR #APDUpostdocday https://t.co/vTVFL0q617
Jun 6, 2019 · 5 likes · 2 shares · 467 followersView post →
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Isaiah Bucur
@IsaiahBucur · X
@JacksonWheat1 @RJDownard @AiG Or this Rands, C. M. et al. 2014. 8.2% of the Human Genome Is Constrained: Variation in Rates of Turnover across Functional Element Classes in the Human Lineage. PLOS Genetics. https://t.co/VBx53j8fQL
@Senta233 @JaTapps @juddclyjohnson @CriticalCripple @JordivisionD @underdog1965 @SciencelsLife @custardsmaster “It is widely accepted that purifying selection persisting over long evolutionary times is a ubiquitous mode of evolution.”
https://t.co/KmsZlhWHPk
1972;23:366–370 https://journals.plos. org/plosgenetics/article?id=10.1371/journal.pgen. 1004525 ENCYCLOPEDIA OF EVOLUTIONARY BIOLOGY. M. Noncoding DNA ...
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