PubHawk
August 2014 PMID 25082703

Modeling digits. Digit patterning is controlled by a Bmp-Sox9-Wnt Turing network modulated by morphogen gradients.

J Raspopovic, L Marcon, L Russo, J Sharpe

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Mentions

22
Peak: 7 in Oct 2025
across 4 sources since Aug 2016

Extended reach

1,198,185
potential audience

Total likes

18,039

Video views

1,196,478

Mentions per month

Aug 2016 – Oct 2025

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  • News12 articles
  • Reddit7 posts
  • YouTube2 videos
  • X / Twitter1 posts

AI synopsis

What people are saying

Participants highlight the study as a prime example of complex systems in biology, with phrases like 'best biology example' and references to modeling and regulation indicating active engagement and recognition of its significance.

AgreementModerate agreement

Most discussions express understanding and appreciation for the biological modeling, indicating general agreement with its significance.

InterestHigh interest

The topic of digit patterning and complex biological networks sparks high curiosity among participants.

EngagementModerate engagement

Comments reflect an active interest, including references to complex systems and the importance of the research for biology.

ImpactModerate impact

While the discussions recognize the importance, there is limited indication that the work is seen as transformative beyond academic interest.

Abstract in brief

  • The development of digits in limbs is regulated by a Turing network involving Bmp, Sox9, and Wnt molecules, which interact through diffusible signals to create the patterning of digital and interdigital regions.
  • Researchers used experiments and computer modeling to show that this network, influenced by morphogen gradients, accurately reproduces digit formation and Sox9 expression patterns seen in both normal and experimental conditions.
  • The study suggests that a combination of growth signals (morphogen gradients) and a self-organizing Turing mechanism ensures reliable and consistent formation of digit patterns during limb development.
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Julia Zeitlinger (@jzeitlinger@genomic.social)
@JuliaZeitlinger · X

@slavov_n @arjunrajlab If that’s what you mean with complex systems, then this is the best biology example I know: https://t.co/VVDDpkyPaN

Oct 6, 2020 · 1 like · 1,518 followers View post →

All mentions

Julia Zeitlinger (@jzeitlinger@genomic.social)
@JuliaZeitlinger · X

@slavov_n @arjunrajlab If that’s what you mean with complex systems, then this is the best biology example I know: https://t.co/VVDDpkyPaN

Oct 6, 2020 · 1 like · 1,518 followers View post →
Brian K Hall - Sally A Moody (Eds.) - Cells in Evolutionary Biology ...
News

doi:10.1126/science.1130670. Schilde, C., Lawal, H. M., Noegel, A. A. ... 1252960. Rebscher, N., Deichmann, C., Sudhop, S., Fritzenwanker, J. H., Green ...

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Top-Down Biology for Regeneration | PDF | Neuroscience | Causality
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Science 345, 13 200. (doi:10.1523/JNEUROSCI.3315-10.2010) deformation and patterned gene expression in 566 –570. (doi:10.1126/science.1252960) 149.

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Digit patterning is controlled by a Bmp-Sox9-Wnt Turing network ...
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Por que 5 dedos? : r/evolution
Reddit

... science.org/doi/abs/10.1126/science.1252960 ): a bioquímica de como o desenvolvimento (crescimento do embrião) funciona. Um padrão muito ...

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Reddit

Un biologiste de l'évo-dévo me l'a expliqué avant, et c'est dû aux morphogènes (https://www.science.org/doi/abs/10.1126/science.1252960 ) ...

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Warum 5 Finger? : r/evolution
Reddit

... science.org/doi/abs/10.1126/science.1252960 ): der Biochemie, wie Entwicklung (Embryonenwachstum) funktioniert. Ein zu feines Muster der ...

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Perché 5 dita? : r/evolution
Reddit

Un biologo evo-devo me lo ha spiegato prima, ed è dovuto ai morfogeni (https://www.science.org/doi/abs/10.1126/science.1252960 ): la ...

Oct 9, 2025 View →
5 उंगलियाँ क्यों? : r/evolution
Reddit

अंकों के लिए, यह एक संतुलन है। एक इवो-डेवो जीवविज्ञानी ने मुझे पहले समझाया था, और यह मॉर्फोजेन्स (https://www.science.org/doi/abs/10.1126/science.1252960 ) पर निर्भर करता है: ...

Oct 9, 2025 View →
¿Por qué 5 dedos? : r/evolution
Reddit

Un biólogo evo-devo me lo explicó una vez, y se debe a los morfógenos (https://www.science.org/doi/abs/10.1126/science.1252960 ): la ...

Oct 9, 2025 View →
¿Por qué tenemos 5 dedos en cada mano?
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2014;345(6196):566-570. doi:10.1126/science.1252960. ARCHIVADO EN: Medicina · Ciencia · Naturaleza.

Jul 23, 2022 View →
¿Por qué no tenemos seis dedos?
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Aug 1, 2014 View →
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Jul 31, 2014 View →
Las matemáticas de Turing explican la formación de los dedos
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Jul 30, 2014 View →