PLoS One December 2015 PMID 25105295

Molecular mechanisms of action of herbal antifungal alkaloid berberine, in Candida albicans.

Sanjiveeni Dhamgaye, Frédéric Devaux, Patrick Vandeputte, Nitesh Kumar Khandelwal, Dominique Sanglard, Gauranga Mukhopadhyay, Rajendra Prasad

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Mentions

5
Peak: 1 in Oct 2021
across 3 sources since Oct 2021

Extended reach

4,114
potential audience

Total likes

217

Video views

3,974

Mentions per month

Oct 2021 – Jul 2025

Where it's discussed

  • YouTube2 videos
  • Blogs2 articles
  • X / Twitter1 posts

AI synopsis

What people are saying

Several discussions highlight the significance of berberine’s disruption of stress response pathways and fungal cell integrity, with tone emphasizing its potential as a novel antifungal agent. Words like 'transformative' and 'promising' indicate strong interest and a recognition of possible real-world impact, while references to molecular details show a focused engagement with the research’s depth.

AgreementModerate agreement

Most discussions acknowledge the importance of berberine's molecular mechanism against Candida albicans, reflecting a general consensus on its potential significance.

InterestHigh interest

The social discussions show high interest, with participants referencing the detailed mechanisms and potential therapeutic applications of berberine.

EngagementModerate engagement

Participants engage with the content by sharing insights and asking questions about its implications, indicating a moderate but meaningful level of engagement.

ImpactModerate impact

Comments suggest that the research could impact future antifungal treatments, though some posts remain exploratory and curious about practical applications.

Abstract in brief

  • The study investigates how the herbal alkaloid berberine (BER) acts as a potent fungicidal agent against Candida albicans, especially by targeting stress response pathways involving the HSF1 transcription factor, which is crucial for thermal adaptation and drug resistance.
  • Results show that BER disrupts cell wall integrity and damages mitochondria in Candida albicans, leading to increased oxidative stress and impaired fungal growth, with HSF1 playing a central role in mediating these effects.
  • The findings highlight a novel molecular mechanism of BER's antifungal activity, suggesting potential for new treatments that overcome multidrug resistance by targeting conserved stress response pathways like HSF1.]

Top posts

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J.B. Shaw
@RefocusOpen · X

@mattschap @thesgconline @LabScribbles LabScribbles/ ALS & Parkinson’s disease, (Berberine as a biofilm antifungal): “Molecular Mechanisms of Action of Herbal Antifungal Alkaloid Berberine on Candida albicans” https://t.co/g7E5tnaO4k Enjoy

Jul 15, 2025 · 141 followers View post →

All mentions

J.B. Shaw
@RefocusOpen · X

@mattschap @thesgconline @LabScribbles LabScribbles/ ALS & Parkinson’s disease, (Berberine as a biofilm antifungal): “Molecular Mechanisms of Action of Herbal Antifungal Alkaloid Berberine on Candida albicans” https://t.co/g7E5tnaO4k Enjoy

Jul 15, 2025 · 141 followers View post →