In healthy young women, 5mg Melatonin, 15 min before a glucose test causes much higher blood glucose in the next 2 h. @martagaraulet found morning melatonin makes insulin less efficient and evening melatonin leads to too much insulin release. https://t.co/FqtCtUyywU https://t.co/yxHKJJdTic
Acute melatonin administration in humans impairs glucose tolerance in both the morning and evening.
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Sep 2019 – Aug 2025Where it's discussed
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What people are saying
The analysis reveals strong agreement with the publication's findings, as many discussions emphasize melatonin's potential to impair glucose metabolism, often mentioning studies, insulin effects, and the risks of timing intake. The tone and choice of words like 'impairs' and 'dangerous' reflect serious concern and in-depth engagement with the topic's implications for health and circadian regulation.
Most discussions acknowledge that acute melatonin intake impairs glucose tolerance, supporting the findings of the publication.
Participants show high interest, referencing specific studies, effects on insulin, and implications for health and circadian mechanisms.
Posts delve into mechanisms, citing studies, and debating the potential risks, indicating deep engagement with the topic.
The discussions highlight significant concerns about melatonin's influence on glucose regulation, suggesting a substantial impact on health and medical advice.
Abstract in brief
- Acute melatonin intake impairs glucose tolerance in humans both in the morning and evening, as shown by increased blood glucose levels after a glucose challenge.
- The study found that melatonin significantly raised the maximum glucose concentration and overall glucose exposure (area under the curve), with different effects on insulin response depending on the time of day — reducing insulin release in the morning and decreasing insulin sensitivity in the evening.
- These results suggest that taking melatonin, especially near meal times, could affect glucose metabolism and might be a concern for individuals at risk of glucose intolerance.]
Top posts
Most liked on X and BlueskyAcute Melatonin Administration in Humans Impairs Glucose Tolerance in Both the Morning and Evening https://t.co/Kdn0p1qqVh https://t.co/Qy9ATchquc
When you take supplemental melatonin more times than not Nature will punish your circadian mechanism around PER1/PER2 NAD+/SIRT1 levels to favor chronic mitochondrial colony failure. Acute melatonin administration in humans impairs glucose tolerance in both the morning and https://t.co/bbq0mHoqxU
Melatonin increases blood sugar. 5 mg melatonin increased AUC glucose by 21% and peak glucose by 121% when taken at 9 am. Taken at 9 pm the increases were 54% (AUC) and 27% (peak). “Acute melatonin administration in humans impairs glucose tolerance in both the morning and https://t.co/IhuGBhDSC2 https://t.co/nUqOhO9GVN
1) La melatonina provoca RI https://t.co/qVpj1iHFVz desde la hipótesis energética: la melatonina redistribuye energía al SI (menos energía para el músculo y el cerebro y más para el SI) https://t.co/w4fX9us5s5
3) La melatonina induce resistencia a la insulina para favorecer la redistribución energética hacia el sistema inmune. Incorporar CHO en la cena podría ser malo para la gestión de la glucosa https://t.co/qVpj1iHFVz
All mentions
Melatonin and Glucose Metabolism: Clarifying Its Role in Diabetes Risk
This video explores melatonin's impact on glucose regulation, highlighting the controversy over its beneficial or harmful effects. It emphasizes the importance of timing in melatonin administration for metabolic health.
Exploring the Comprehensive Benefits of Melatonin for Health
In this video, we discuss melatonin benefits and how to supplement for better health and longevity. Key points include its effects on sleep, blood sugar levels, depression, inflammation, and immune function, as well as…
RT @lowmegatron: Melatonin increases blood sugar. 5 mg melatonin increased AUC glucose by 21% and peak glucose by 121% when taken at 9 am.…
Rubio-Sastre Acute melatonin administration in humans impairs glucose tolerance in both the morning and evening. Sleep. 2014 Oct 1;37(10):1715-9. Lauritzen ES,. Three months of melatonin treatment reduces insulin sensitivity in patients with type 2 diabetes-A randomized
RT @lowmegatron: Melatonin increases blood sugar. 5 mg melatonin increased AUC glucose by 21% and peak glucose by 121% when taken at 9 am.…
RT @lowmegatron: Melatonin increases blood sugar. 5 mg melatonin increased AUC glucose by 21% and peak glucose by 121% when taken at 9 am.…
RT @lowmegatron: Melatonin increases blood sugar. 5 mg melatonin increased AUC glucose by 21% and peak glucose by 121% when taken at 9 am.…
RT @lowmegatron: Melatonin increases blood sugar. 5 mg melatonin increased AUC glucose by 21% and peak glucose by 121% when taken at 9 am.…
Melatonin increases blood sugar. 5 mg melatonin increased AUC glucose by 21% and peak glucose by 121% when taken at 9 am. Taken at 9 pm the increases were 54% (AUC) and 27% (peak). “Acute melatonin administration in humans impairs glucose tolerance in both the morning and https://t.co/IhuGBhDSC2 https://t.co/nUqOhO9GVN
RT @DrJackKruse: When you take supplemental melatonin more times than not Nature will punish your circadian mechanism around PER1/PER2 NAD+…
Rubio-Sastre P, Scheer FA, Gómez-Abellán P, Madrid JA, Garaulet M. Acute melatonin administration in humans impairs glucose tolerance in both the morning and evening. Sleep. 2014 Oct 1;37(10):1715-9. doi: 10.5665/sleep.4088. PMID: 25197811; PMCID: PMC4173928.
RT @DrJackKruse: When you take supplemental melatonin more times than not Nature will punish your circadian mechanism around PER1/PER2 NAD+…
RT @DrJackKruse: When you take supplemental melatonin more times than not Nature will punish your circadian mechanism around PER1/PER2 NAD+…
RT @DrJackKruse: When you take supplemental melatonin more times than not Nature will punish your circadian mechanism around PER1/PER2 NAD+…
RT @DrJackKruse: When you take supplemental melatonin more times than not Nature will punish your circadian mechanism around PER1/PER2 NAD+…
RT @DrJackKruse: When you take supplemental melatonin more times than not Nature will punish your circadian mechanism around PER1/PER2 NAD+…
RT @DrJackKruse: When you take supplemental melatonin more times than not Nature will punish your circadian mechanism around PER1/PER2 NAD+…
RT @DrJackKruse: When you take supplemental melatonin more times than not Nature will punish your circadian mechanism around PER1/PER2 NAD+…
RT @DrJackKruse: When you take supplemental melatonin more times than not Nature will punish your circadian mechanism around PER1/PER2 NAD+…
RT @DrJackKruse: When you take supplemental melatonin more times than not Nature will punish your circadian mechanism around PER1/PER2 NAD+…
When you take supplemental melatonin more times than not Nature will punish your circadian mechanism around PER1/PER2 NAD+/SIRT1 levels to favor chronic mitochondrial colony failure. Acute melatonin administration in humans impairs glucose tolerance in both the morning and https://t.co/bbq0mHoqxU
RT @Grimhood: Acute Melatonin Administration in Humans Impairs Glucose Tolerance in Both the Morning and Evening https://t.co/Kdn0p1qqVh ht…
RT @Grimhood: Acute Melatonin Administration in Humans Impairs Glucose Tolerance in Both the Morning and Evening https://t.co/Kdn0p1qqVh ht…
RT @Grimhood: Acute Melatonin Administration in Humans Impairs Glucose Tolerance in Both the Morning and Evening https://t.co/Kdn0p1qqVh ht…
RT @Grimhood: Acute Melatonin Administration in Humans Impairs Glucose Tolerance in Both the Morning and Evening https://t.co/Kdn0p1qqVh ht…
RT @Grimhood: Acute Melatonin Administration in Humans Impairs Glucose Tolerance in Both the Morning and Evening https://t.co/Kdn0p1qqVh ht…
RT @Grimhood: Acute Melatonin Administration in Humans Impairs Glucose Tolerance in Both the Morning and Evening https://t.co/Kdn0p1qqVh ht…
RT @Grimhood: Acute Melatonin Administration in Humans Impairs Glucose Tolerance in Both the Morning and Evening https://t.co/Kdn0p1qqVh ht…
RT @Grimhood: Acute Melatonin Administration in Humans Impairs Glucose Tolerance in Both the Morning and Evening https://t.co/Kdn0p1qqVh ht…
Acute Melatonin Administration in Humans Impairs Glucose Tolerance in Both the Morning and Evening https://t.co/Kdn0p1qqVh https://t.co/Qy9ATchquc
@Scrambu11 @DorissLoh Here's a small study showing acute doses impair glucose tolerance though. No one is going to evaluate chronic exogenous dosing of melatonin for years, the same way they've studied the effects of hypoactive/disrupted melatonin systems over time https://t.co/m5jYE5yRV9
@SaulNutri Saúl, ¿cómo podríamos interpretar y aplicar entonces resultados aparentemente perjudiciales del consumo de melatonina? https://t.co/eVkDEd3CfM
RT @SatchinPanda: In healthy young women, 5mg Melatonin, 15 min before a glucose test causes much higher blood glucose in the next 2 h. @ma…
RT @SatchinPanda: In healthy young women, 5mg Melatonin, 15 min before a glucose test causes much higher blood glucose in the next 2 h. @ma…
RT @SatchinPanda: In healthy young women, 5mg Melatonin, 15 min before a glucose test causes much higher blood glucose in the next 2 h. @ma…
RT @SatchinPanda: In healthy young women, 5mg Melatonin, 15 min before a glucose test causes much higher blood glucose in the next 2 h. @ma…
RT @SatchinPanda: In healthy young women, 5mg Melatonin, 15 min before a glucose test causes much higher blood glucose in the next 2 h. @ma…
RT @SatchinPanda: In healthy young women, 5mg Melatonin, 15 min before a glucose test causes much higher blood glucose in the next 2 h. @ma…
RT @SatchinPanda: In healthy young women, 5mg Melatonin, 15 min before a glucose test causes much higher blood glucose in the next 2 h. @ma…
RT @SatchinPanda: In healthy young women, 5mg Melatonin, 15 min before a glucose test causes much higher blood glucose in the next 2 h. @ma…
RT @SatchinPanda: In healthy young women, 5mg Melatonin, 15 min before a glucose test causes much higher blood glucose in the next 2 h. @ma…
RT @SatchinPanda: In healthy young women, 5mg Melatonin, 15 min before a glucose test causes much higher blood glucose in the next 2 h. @ma…
RT @SatchinPanda: In healthy young women, 5mg Melatonin, 15 min before a glucose test causes much higher blood glucose in the next 2 h. @ma…
RT @SatchinPanda: In healthy young women, 5mg Melatonin, 15 min before a glucose test causes much higher blood glucose in the next 2 h. @ma…
RT @SatchinPanda: In healthy young women, 5mg Melatonin, 15 min before a glucose test causes much higher blood glucose in the next 2 h. @ma…
RT @SatchinPanda: In healthy young women, 5mg Melatonin, 15 min before a glucose test causes much higher blood glucose in the next 2 h. @ma…
RT @SatchinPanda: In healthy young women, 5mg Melatonin, 15 min before a glucose test causes much higher blood glucose in the next 2 h. @ma…
RT @SatchinPanda: Taking melatonin close to mealtime can be dangerous for blood glucose. @martagaraulet showed even in young healthy women,…
RT @SatchinPanda: In healthy young women, 5mg Melatonin, 15 min before a glucose test causes much higher blood glucose in the next 2 h. @ma…
RT @SatchinPanda: Taking melatonin close to mealtime can be dangerous for blood glucose. @martagaraulet showed even in young healthy women,…
RT @SatchinPanda: In healthy young women, 5mg Melatonin, 15 min before a glucose test causes much higher blood glucose in the next 2 h. @ma…
RT @SatchinPanda: In healthy young women, 5mg Melatonin, 15 min before a glucose test causes much higher blood glucose in the next 2 h. @ma…
The study mentioned in tweet 3 is the one by Lusardi et al. https://t.co/ygGCttp7VI Here's a study on the acute effects of 5 mg of liquid (!) melatonin on blood glucose regulation - impaired acutely after both morning & evening melatonin: https://t.co/gl89gfhTMG https://t.co/PHu0L6fYeT
RT @SatchinPanda: In healthy young women, 5mg Melatonin, 15 min before a glucose test causes much higher blood glucose in the next 2 h. @ma…
RT @SatchinPanda: In healthy young women, 5mg Melatonin, 15 min before a glucose test causes much higher blood glucose in the next 2 h. @ma…
RT @SatchinPanda: In healthy young women, 5mg Melatonin, 15 min before a glucose test causes much higher blood glucose in the next 2 h. @ma…
RT @SatchinPanda: In healthy young women, 5mg Melatonin, 15 min before a glucose test causes much higher blood glucose in the next 2 h. @ma…
RT @SatchinPanda: Taking melatonin close to mealtime can be dangerous for blood glucose. @martagaraulet showed even in young healthy women,…
RT @SatchinPanda: In healthy young women, 5mg Melatonin, 15 min before a glucose test causes much higher blood glucose in the next 2 h. @ma…
RT @SatchinPanda: In healthy young women, 5mg Melatonin, 15 min before a glucose test causes much higher blood glucose in the next 2 h. @ma…
RT @SatchinPanda: In healthy young women, 5mg Melatonin, 15 min before a glucose test causes much higher blood glucose in the next 2 h. @ma…
RT @SatchinPanda: Taking melatonin close to mealtime can be dangerous for blood glucose. @martagaraulet showed even in young healthy women,…
RT @SatchinPanda: In healthy young women, 5mg Melatonin, 15 min before a glucose test causes much higher blood glucose in the next 2 h. @ma…
RT @SatchinPanda: In healthy young women, 5mg Melatonin, 15 min before a glucose test causes much higher blood glucose in the next 2 h. @ma…
RT @SatchinPanda: Taking melatonin close to mealtime can be dangerous for blood glucose. @martagaraulet showed even in young healthy women,…
RT @SatchinPanda: Taking melatonin close to mealtime can be dangerous for blood glucose. @martagaraulet showed even in young healthy women,…
RT @SatchinPanda: In healthy young women, 5mg Melatonin, 15 min before a glucose test causes much higher blood glucose in the next 2 h. @ma…
RT @SatchinPanda: In healthy young women, 5mg Melatonin, 15 min before a glucose test causes much higher blood glucose in the next 2 h. @ma…
RT @SatchinPanda: In healthy young women, 5mg Melatonin, 15 min before a glucose test causes much higher blood glucose in the next 2 h. @ma…
RT @SatchinPanda: Taking melatonin close to mealtime can be dangerous for blood glucose. @martagaraulet showed even in young healthy women,…
RT @SatchinPanda: In healthy young women, 5mg Melatonin, 15 min before a glucose test causes much higher blood glucose in the next 2 h. @ma…
RT @SatchinPanda: Taking melatonin close to mealtime can be dangerous for blood glucose. @martagaraulet showed even in young healthy women,…
RT @SatchinPanda: In healthy young women, 5mg Melatonin, 15 min before a glucose test causes much higher blood glucose in the next 2 h. @ma…
RT @SatchinPanda: Taking melatonin close to mealtime can be dangerous for blood glucose. @martagaraulet showed even in young healthy women,…
In healthy young women, 5mg Melatonin, 15 min before a glucose test causes much higher blood glucose in the next 2 h. @martagaraulet found morning melatonin makes insulin less efficient and evening melatonin leads to too much insulin release. https://t.co/FqtCtUyywU https://t.co/yxHKJJdTic
@DrDrChristel Generellt kan man spekulera om t.ex. ökad risk för störd glukosreglering (https://t.co/qlAsHFhFdA), särskilt hos de med en viss genvariant av melatoninreceptorn MTNR1B (https://t.co/pE3zVH0ZoI), som reglerar insulinutsöndring på betacellerna (se t.ex. https://t.co/CapuQUXJmj)
3) La melatonina induce resistencia a la insulina para favorecer la redistribución energética hacia el sistema inmune. Incorporar CHO en la cena podría ser malo para la gestión de la glucosa https://t.co/qVpj1iHFVz
RT @PauOller: 1) La melatonina provoca RI https://t.co/qVpj1iHFVz desde la hipótesis energética: la melatonina redistribuye energía al SI (…
1) La melatonina provoca RI https://t.co/qVpj1iHFVz desde la hipótesis energética: la melatonina redistribuye energía al SI (menos energía para el músculo y el cerebro y más para el SI) https://t.co/w4fX9us5s5
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