November 2014 PMID 25213996

Pilot study of the 5-HT2AR agonist psilocybin in the treatment of tobacco addiction.

Matthew W Johnson, Albert Garcia-Romeu, Mary P Cosimano, Roland R Griffiths

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Mentions

238
Peak: 4 in Jul 2021
across 7 sources since Jul 2020

Extended reach

24,201
potential audience

Total likes

39

Video views

747

Mentions per month

Jul 2020 – Oct 2025

Where it's discussed

  • News180 articles
  • Facebook24 posts
  • Blogs16 articles
  • X / Twitter13 posts
  • YouTube2 videos
  • Reddit2 posts
  • Bluesky1 posts

AI synopsis

What people are saying

The groups of discussions collectively show a strong belief in the transformative potential of psilocybin for smoking cessation, using enthusiastic language like 'most effective' and references to high success rates (80%), along with questions about dosage effects, which reveal active engagement and curiosity about the research. Technical references and comparisons to existing treatments highlight the perceived high impact of these findings.

AgreementStrong agreement

Most discussions highlight the promising results of the study, emphasizing high quit rates and comparing them favorably to traditional treatments.

InterestHigh interest

The posts demonstrate a high level of curiosity about psilocybin's potential, with mentions of future research and different applications, indicating strong engagement with the topic.

EngagementHigh engagement

Several posts provide detailed summaries, comparisons, and questions about the methodology, showing deep involvement in understanding the implications.

ImpactHigh impact

The discussions suggest that the findings could significantly influence future approaches to addiction treatment, potentially reshaping perceptions of psychedelics in medicine.

Abstract in brief

  • The study explored the safety and feasibility of using psilocybin, a hallucinogen, alongside a structured 15-week smoking cessation program, with participants showing promising abstinence rates.
  • Despite the open-label design limiting definitive conclusions, 80% of participants remained abstinent after six months, which is higher than typical cessation success rates of around 35%.
  • The results suggest psilocybin could be a promising addition to addiction treatments, paving the way for future research to better understand its effectiveness and how it works in helping people quit smoking.]

Top posts

Most liked on X and Bluesky
Raphael Sirtoli
@raphaels7 · X

"the most effective smoking cessation medications typically demonstrate < 31% abstinence at 12 months post-treatment, whereas [magic mushrooms

Jul 1, 2021 · 9 likes · 4 shares · 8,598 followers View post →
Brian Barnett
@BrianBarnettMD · X

As far as I know, this is the only study that comments on whether a second dose of psilocybin increases response rates for any condition. “All participants who quit smoking did so after their initial moderate-dose session.” Anyone know of any other data? https://t.co/pi6ciqb5B6

Sep 17, 2025 · 2 likes · 1,083 followers View post →
M.Bernie MD
@mbzbmd · X

The highest rate of treatment success for tobacco addiction is….. shrooms!

Jul 12, 2024 · 2 likes · 480 followers View post →
Blossom
@blossomact · X

Enter psilocybin, Nayak describes the 2014 smoking cessation trial 15 participants 80% quit smoking (6 months) 67% still smoke-free at 12 months But, open-label trial, so take it with a grain of salt https://t.co/edpkpqbqJG

Dec 4, 2021 · 1 like · 3,349 followers View post →
Fungo
@fungistan.bsky.social · Bluesky

pubmed.ncbi.nlm.nih.gov/41008340/ adicciones y psicodélicos pubmed.ncbi.nlm.nih.gov/25213996/ tabaco y psilocibina pubmed.ncbi.nlm.nih.gov/35711024/ psilocibina y desórdenes asociados a trauma

Oct 1, 2025 · 1 like View post →
Blossom
@blossomact · X

More notes on this study: https://t.co/QCGqXSfLxk Original study: https://t.co/edpkpqbqJG

Jan 4, 2021 · 3,349 followers View post →

All mentions

Fungo
@fungistan.bsky.social · Bluesky

pubmed.ncbi.nlm.nih.gov/41008340/ adicciones y psicodélicos pubmed.ncbi.nlm.nih.gov/25213996/ tabaco y psilocibina pubmed.ncbi.nlm.nih.gov/35711024/ psilocibina y desórdenes asociados a trauma

Oct 1, 2025 · 1 like View post →
wu
@wu662571429198 · X

@PortSzymon @MMalolepszy93 Pierdolenie, SYSTEM ci wmówił, żebyś nie jadł bo poszerzają świadomość. Poza tym te grzyby skutecznie wyprowadzają z nałogów: Pilot study of the 5-HT2AR agonist psilocybin in the treatment of tobacco addiction https://t.co/SU9CM7BZQB

Sep 29, 2025 · 7 followers View post →
Brian Barnett
@BrianBarnettMD · X

As far as I know, this is the only study that comments on whether a second dose of psilocybin increases response rates for any condition. “All participants who quit smoking did so after their initial moderate-dose session.” Anyone know of any other data? https://t.co/pi6ciqb5B6

Sep 17, 2025 · 2 likes · 1,083 followers View post →
Max Wolff
@trpwolff · X

@tkaiser_science Here is a small pilot study testing psilocybin + CBT for nicotine use disorder: https://t.co/p6tuqKExFm A larger study from the same group @JHPsychedelics has been concluded recently. Looking forward to see the results.

Jul 27, 2024 · 2,845 followers View post →
M.Bernie MD
@mbzbmd · X

The highest rate of treatment success for tobacco addiction is….. shrooms!

Jul 12, 2024 · 2 likes · 480 followers View post →
Blossom
@blossomact · X

Enter psilocybin, Nayak describes the 2014 smoking cessation trial 15 participants 80% quit smoking (6 months) 67% still smoke-free at 12 months But, open-label trial, so take it with a grain of salt https://t.co/edpkpqbqJG

Dec 4, 2021 · 1 like · 3,349 followers View post →
Guðmundur Jóhannsson
@gfj1979 · X

RT @raphaels7: "the most effective smoking cessation medications typically demonstrate < 31% abstinence at 12 months post-treatment, wherea…

Jul 1, 2021 · 4 shares · 2,019 followers View post →
Dan Donaldson
@DanDona21972788 · X

RT @raphaels7: "the most effective smoking cessation medications typically demonstrate < 31% abstinence at 12 months post-treatment, wherea…

Jul 1, 2021 · 4 shares · 65 followers View post →
not░zero░sum
@n0tzer0sum · X

RT @raphaels7: "the most effective smoking cessation medications typically demonstrate < 31% abstinence at 12 months post-treatment, wherea…

Jul 1, 2021 · 4 shares · 358 followers View post →
Raphael Sirtoli
@raphaels7 · X

"the most effective smoking cessation medications typically demonstrate < 31% abstinence at 12 months post-treatment, whereas [magic mushrooms

Jul 1, 2021 · 9 likes · 4 shares · 8,598 followers View post →
Blossom
@blossomact · X

More notes on this study: https://t.co/QCGqXSfLxk Original study: https://t.co/edpkpqbqJG

Jan 4, 2021 · 3,349 followers View post →
cyrilio MSc.
@Mod_Cyrilio · X

@EU_Health Did you know that LSD is very promising for help with smoking session. Here's some research you need to read up to improve your anti smoking laws and actually help people quit: https://t.co/ZpmltkZXsC https://t.co/zNiiIpXoJS #HarmReduction @PhilipMorris_NL

Dec 18, 2020 · 992 followers View post →
@maxminja
@369MaxMinja · X

RT @Sansero_Life: Pilot Study of the 5-HT2AR Agonist #Psilocybin in the Treatment of Tobacco Addiction https://t.co/vMLIbDLB9H #psilocybin…

Aug 15, 2020 · 1 share · 179 followers View post →
Sansero Life Sciences
@Sansero_Life · X

Pilot Study of the 5-HT2AR Agonist #Psilocybin in the Treatment of Tobacco Addiction https://t.co/vMLIbDLB9H #psilocybinresearch #tobacco

Aug 14, 2020 · 1 share · 95 followers View post →