Obesity (Silver Spring) December 2014 PMID 25236175

Metabolic adaptation following massive weight loss is related to the degree of energy imbalance and changes in circulating leptin.

Nicolas D Knuth, Darcy L Johannsen, Robyn A Tamboli, Pamela A Marks-Shulman, Robert Huizenga, Kong Y Chen, Naji N Abumrad, Eric Ravussin, Kevin D Hall

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Mentions

67
Peak: 5 in Dec 2025
across 5 sources since Dec 2014

Extended reach

43,207
potential audience

Total likes

876

Video views

36,093

Mentions per month

Dec 2014 – Dec 2025

Where it's discussed

  • Facebook50 posts
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  • X / Twitter3 posts
  • Instagram3 posts
  • YouTube2 videos

AI synopsis

What people are saying

The overall discussions reflect a strong interest in the long-term effects of weight loss methods, with posts highlighting studies comparing surgical and non-surgical approaches. The tone varies from informative to sarcastic, such as calling out misconceptions and emphasizing scientific evidence, which demonstrates thoughtful engagement and recognition of the study's importance.

AgreementModerate agreement

Most posts acknowledge the significance of the study, especially in contrasting different weight loss methods and their long-term effects.

InterestHigh interest

Discussions show high interest, with references to follow-up data and debates about weight loss strategies.

EngagementModerate engagement

Some posts actively debate the scientific findings and compare them to popular programs, indicating moderate engagement.

ImpactModerate impact

While not universally transformative, the posts highlight how this research influences understanding of weight management and obesity treatment.

Abstract in brief

  • The study compares two groups of obese individuals who lost a similar amount of weight: one through bariatric surgery (RYGB) and the other through a calorie-restricted diet combined with vigorous exercise (The Biggest Loser).
  • It finds that both groups experienced a decrease in resting metabolic rate (RMR) that was more significant than expected based on changes in body composition, with the decline being linked to the level of energy imbalance and circulating leptin levels.
  • Despite similar weight loss, the group that exercised and dieted preserved more fat-free mass and showed greater metabolic adaptation, highlighting the role of energy balance and leptin in metabolic changes after weight loss.]

Top posts

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TJ Jurkiewicz | Fat Loss Coach
@TheFitnessJurk · X

Remember The Biggest Loser? Contestants lost insane amounts of weight in just a few months. But a 6-year follow-up study tracked them afterward and the results were staggering. Here is how to avoid the same fate.

Jul 7, 2025 · 3 likes · 5,987 followers View post →
Tough Love Jesus
@kderosa · X

@Wiseguy42727489 @JasonDoesTwitta @_Nick_Diller @ericasaysyes @dogdadCA Lol. It’s not my fault you’re blissfully unaware of the science. It’s better to get gastric bypass surgery than do the stupid shit you’re touting. https://t.co/5t5fshWZwG https://t.co/VcFVVYlMtd

Jan 26, 2023 · 410 followers View post →

All mentions

TJ Jurkiewicz | Fat Loss Coach
@TheFitnessJurk · X

Remember The Biggest Loser? Contestants lost insane amounts of weight in just a few months. But a 6-year follow-up study tracked them afterward and the results were staggering. Here is how to avoid the same fate.

Jul 7, 2025 · 3 likes · 5,987 followers View post →
Dollynho Fazul Eli
@dollynhofazul2 · X

@Wagner_Guinne @Miniminvs Wagner mais uma, olha esse estudo comparando bariátrica com os participantes vencedores do programa biggest losers https://t.co/So4KzoKx4c

Aug 10, 2023 · 97 followers View post →
Tough Love Jesus
@kderosa · X

@Wiseguy42727489 @JasonDoesTwitta @_Nick_Diller @ericasaysyes @dogdadCA Lol. It’s not my fault you’re blissfully unaware of the science. It’s better to get gastric bypass surgery than do the stupid shit you’re touting. https://t.co/5t5fshWZwG https://t.co/VcFVVYlMtd

Jan 26, 2023 · 410 followers View post →
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