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This discussion exemplifies mild interest and engagement by linking the research findings to existing medications like Propecia, pointing out that low-dose use may not cause serious side effects but neglects the role of 5-AR type 1 in the liver. The tone is analytical and cautious, emphasizing the importance of understanding the specific functions of different enzyme types in medical treatment.
The discussion suggests that the user agrees with the relevance of 5-AR type 1's role in liver health, emphasizing the importance highlighted in the publication.
The post shows moderate interest, focusing on specific medications and their side effects rather than the broader implications of the research.
The user engages by connecting the research to real-world medications like Propecia, indicating a thoughtful consideration of how this information might impact clinical understanding.
The comment hints at clinical relevance but does not directly suggest a transformative impact on medical practices or understanding.
@NotQuiteMidlife i think at </= 1 mg per day, Propecia (which does not inhibit 5-AR type 2 at low doses) is pretty unlikely to cause serious sexual side effects. what they failed to note when it was initially approved, however, is that 5-AR type 1 is important in the liver https://t.co/tE8beIiWb3
Long-term use of finasteride and dutasteride may lead to health issues such as fatty liver, insulin resistance, and kidney problems, highlighting the need for caution and further research into their long-term effects.
Men taking steroid 5-reductase inhibitors like dutasteride or finasteride for benign prostatic hyperplasia show a modestly increased risk of developing type 2 diabetes, based on population studies from the UK and Taiwan.
@NotQuiteMidlife i think at </= 1 mg per day, Propecia (which does not inhibit 5-AR type 2 at low doses) is pretty unlikely to cause serious sexual side effects. what they failed to note when it was initially approved, however, is that 5-AR type 1 is important in the liver https://t.co/tE8beIiWb3
2013;33(1):249–69. doi: 10.1146/annurev-nutr-071812-161139. pmid:23528177. 3 ... doi: 10.2337/db14-0319. pmid:24947364. 25. Locke AE, Kahali B, Berndt SI ...
... 10.2337/db14-0249. 7 Liver damage. Hazlehurst JM et al, Dual 5α-reductase inhibition promotes hepatic lipid accumulation in humans, J Clin ...
Handb Clin Neurol 2014; 126: 249-259. 7. Roh E, Song DK, Kim MS ... doi: 10.2337/db14-0340 12. Song Y, Ding W, Bei Y. Insulin is a ...
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