PubHawk
PLoS One June 2015 PMID 25295520

A validated age-related normative model for male total testosterone shows increasing variance but no decline after age 40 years.

Thomas W Kelsey, Lucy Q Li, Rod T Mitchell, Ashley Whelan, Richard A Anderson, W Hamish B Wallace

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Mentions

26
Peak: 2 in Feb 2021
across 5 sources since Feb 2021

Extended reach

884,952
potential audience

Total likes

18,557

Video views

483,960

Mentions per month

Feb 2021 – Sep 2025

Where it's discussed

  • News12 articles
  • X / Twitter9 posts
  • YouTube2 videos
  • Facebook2 posts
  • Bluesky1 posts

AI synopsis

What people are saying

Discussions reflect a positive reception to the research, highlighting points like 'testosterone stabilizes at around age 40' and 'the upper 10% of 60-year-old men still have high levels,' showing interest in individual differences and debunking myths about decline. The tone indicates curiosity and acknowledgment of nuanced findings, emphasizing relevance for health management.

AgreementModerate agreement

Most discussions support the findings that testosterone levels do not decline after 40, aligning with the study's conclusions.

InterestHigh interest

Participants demonstrate high curiosity, engaging with detailed findings about individual variability and implications for health.

EngagementModerate engagement

Posts reference specific data, such as the stability of testosterone levels and the increased variability in older men, indicating thoughtful engagement.

ImpactModerate impact

There is an acknowledgment that the study could influence how testosterone aging is understood and managed, suggesting moderate impact.

Abstract in brief

  • The study develops and validates a reference model for male total testosterone levels across different ages, showing that testosterone peaks around age 19 and decreases up to age 40 but then remains relatively stable afterward.
  • The model indicates that while the average testosterone does not decline further with age, the variation in testosterone levels increases after age 40, meaning individual testosterone levels can be more unpredictable in older men.
  • This research fills a gap in clinical practice by providing an age-specific normative range for testosterone, which can help diagnose and manage conditions like hypogonadism more accurately across the lifespan.]
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Top posts

Most liked on X and Bluesky
Bryce Hanna
@photobiogenesis · X

This study also found no decline with age, just more variation, likely also tied to other health factors The upper 10% of 60 year old men still had testosterone levels over 650 ng/dl! https://t.co/qFOG5Mwe2i

Feb 26, 2021 · 30 likes · 1 share · 34,085 followers View post →
Crémieux
@cremieuxrecueil · X

@UsingLyft @Duderichy @eigenrobot Maybe, but it doesn't seem like the decline is really large enough to explain what's going on. I suspect it has more to do with neural development. Two graphs, two sources: https://t.co/TS7rBYV4hL, https://t.co/oVnCySsJ9H https://t.co/ZWaP4M8wjf

Apr 17, 2023 · 12 likes · 279,738 followers View post →
أسيد | OSAID
@OSAID_FIT · X

على موضوع إنخفاض هرمون التيستوستيرون بعد سن الثلاثين ، الموضوع عليه كلام كثير وممكن أغير رأي خاصة مع وجود بعض الأدلة إللي بينت خلاف ذلك الإنخفاض كان في الأشخاص إللي عانوا من مشاكل صحية وأبرزها ( السمنة / الإكتئاب ) https://t.co/am7ZP6mi9j https://t.co/Qw98ZTwEuZ https://t.co/HHrljohNmX

Nov 3, 2021 · 8 likes · 2 shares · 25,551 followers View post →
Bianco
@bianco_____ · X

@cdiviuvo @mab_sp125 https://t.co/Xo0zv87WfA

Jan 4, 2025 · 5 likes · 4,176 followers View post →
Abud Bakri MD
@AbudBakri · X

Person specific and variable. However it seems it peaks in puberty and gets to a baseline at 40, according to this paper Later on in life it becomes more variable, which is wild that some men maintain high levels https://t.co/jWKYLn5Ign https://t.co/uk4YX33z3W https://t.co/RkL1HjYwXR

Oct 24, 2022 · 55,235 followers View post →
GiagT
@GiagkT · X

A Validated Age-Related Normative Model for Male Total Testosterone Shows Increasing Variance but No Decline after Age 40 Years https://t.co/H6lkdAMNAg

Mar 31, 2021 · 1,826 followers View post →

All mentions

justinstarren.bsky.social
@justinstarren.bsky.social · Bluesky

Testosterone normally does not drop with age. PLoS One. 2014 Oct 8;9(10):e109346. doi: 10.1371/journal.pone.0109346

Apr 23, 2025 View post →
Bianco
@bianco_____ · X

@cdiviuvo @mab_sp125 https://t.co/Xo0zv87WfA

Jan 4, 2025 · 5 likes · 4,176 followers View post →
Johnnyvee 333
@Johnnyvee333 · X

@realMeetJames @SBakerMD T actually stabilises at around age 40 and doesn't decline further later in life on average. But there's more heterogeneity with age, and that's where diet/lifestyle comes into play... https://t.co/85frGDgElM

Jun 12, 2023 · 28 followers View post →
Crémieux
@cremieuxrecueil · X

@UsingLyft @Duderichy @eigenrobot Maybe, but it doesn't seem like the decline is really large enough to explain what's going on. I suspect it has more to do with neural development. Two graphs, two sources: https://t.co/TS7rBYV4hL, https://t.co/oVnCySsJ9H https://t.co/ZWaP4M8wjf

Apr 17, 2023 · 12 likes · 279,738 followers View post →
TRTed
@TRTed_ · X

A model built by Kelsey et al (2013) converged 13 studies to observe total testosterone levels across the lifespan. https://t.co/VbzEfo56Hj

Nov 22, 2022 · 91 followers View post →
Abud Bakri MD
@AbudBakri · X

Person specific and variable. However it seems it peaks in puberty and gets to a baseline at 40, according to this paper Later on in life it becomes more variable, which is wild that some men maintain high levels https://t.co/jWKYLn5Ign https://t.co/uk4YX33z3W https://t.co/RkL1HjYwXR

Oct 24, 2022 · 55,235 followers View post →
أسيد | OSAID
@OSAID_FIT · X

على موضوع إنخفاض هرمون التيستوستيرون بعد سن الثلاثين ، الموضوع عليه كلام كثير وممكن أغير رأي خاصة مع وجود بعض الأدلة إللي بينت خلاف ذلك الإنخفاض كان في الأشخاص إللي عانوا من مشاكل صحية وأبرزها ( السمنة / الإكتئاب ) https://t.co/am7ZP6mi9j https://t.co/Qw98ZTwEuZ https://t.co/HHrljohNmX

Nov 3, 2021 · 8 likes · 2 shares · 25,551 followers View post →
GiagT
@GiagkT · X

A Validated Age-Related Normative Model for Male Total Testosterone Shows Increasing Variance but No Decline after Age 40 Years https://t.co/H6lkdAMNAg

Mar 31, 2021 · 1,826 followers View post →
ENDALA klinika zdraví
@endalaclinic · X

RT @ck_eternity_: This study also found no decline with age, just more variation, likely also tied to other health factors The upper 10% o…

Feb 27, 2021 · 1 share · 254 followers View post →
Bryce Hanna
@photobiogenesis · X

This study also found no decline with age, just more variation, likely also tied to other health factors The upper 10% of 60 year old men still had testosterone levels over 650 ng/dl! https://t.co/qFOG5Mwe2i

Feb 26, 2021 · 30 likes · 1 share · 34,085 followers View post →