November 2014 PMID 25349387

A circadian gene expression atlas in mammals: implications for biology and medicine.

Ray Zhang, Nicholas F Lahens, Heather I Ballance, Michael E Hughes, John B Hogenesch

Mentions

143
Peak: 3 in Jul 2022
across 5 sources since Jul 2022

Extended reach

41,484
potential audience

Total likes

35

Video views

1,050

Mentions per month

Jul 2022 – Jun 2025

Where it's discussed

  • News104 articles
  • Blogs24 articles
  • Facebook6 posts
  • X / Twitter5 posts
  • YouTube4 videos

AI synopsis

What people are saying

Discussions show a strong interest in the implications of the article, with bloggers emphasizing how many drugs target cycling genes and how timing treatments could improve outcomes, evidenced by phrases like 'many drugs target cycling genes' and 'should be investigated for enhanced outcomes.' The tone indicates engagement with its potential for impact on medicine and biology, reflecting a recognition of the research's transformative possibilities.

AgreementModerate agreement

Most posts recognize the significance of the research, highlighting its relevance for medicine and drug timing strategies.

InterestHigh interest

Discussions demonstrate high curiosity about how circadian gene data could influence treatments and biological understanding.

EngagementModerate engagement

Posts include references to implications and future applications, showing thoughtful consideration.

ImpactHigh impact

Comments underscore the potential for medical advancements and personalized therapy based on the study's findings.

Abstract in brief

  • The study used RNAseq and DNA arrays to analyze gene expression in 12 mouse organs over time, revealing that 43% of protein-coding genes show circadian rhythms, mostly peaking before dawn and dusk.
  • Rhythmic genes tend to cluster, be longer, and have more splice variants, with an intricate, time-based regulation of gene pathways across the body, including many noncoding RNAs that are conserved between mice and humans.
  • Most major drugs target products of rhythmic genes, suggesting that timing their administration (chronotherapy) could improve treatment effectiveness, emphasizing the importance of the circadian clock in both biological processes and medicine.]

Top posts

Most liked on X and Bluesky
Leah Kottyan
@Kottyan_Lab · X

The article discusses the implications of the research @jbhclock published in @PNASNews : "A circadian gene expression atlas in mammals: Implications for biology and medicine" https://t.co/bFUqIUgLuQ

Jul 6, 2022 · 4 likes · 1 share · 707 followers View post →
BowTiedPhys
@BowTiedPhys · X

https://t.co/bImq6mVHhD

Jan 10, 2024 · 1 like · 26,328 followers View post →
rebecca
@rebecca_sansale · X

@owl_posting This goes beyond cancer too! Many drugs target cycling genes and should be investigated for enhanced outcomes based on dosage timing: https://t.co/UUT4MAj2sz

Jun 7, 2025 · 1 like · 96 followers View post →
Sofia
@Chris_tinees · X

A circadian gene expression atlas in mammals: Implications for biology and medicine | Proceedings of the National Academy of Sciences https://t.co/9Pub2XpSG9

Jul 13, 2022 · 10,309 followers View post →

All mentions

rebecca
@rebecca_sansale · X

@owl_posting This goes beyond cancer too! Many drugs target cycling genes and should be investigated for enhanced outcomes based on dosage timing: https://t.co/UUT4MAj2sz

Jun 7, 2025 · 1 like · 96 followers View post →
BowTiedPhys
@BowTiedPhys · X

https://t.co/bImq6mVHhD

Jan 10, 2024 · 1 like · 26,328 followers View post →
Sofia
@Chris_tinees · X

A circadian gene expression atlas in mammals: Implications for biology and medicine | Proceedings of the National Academy of Sciences https://t.co/9Pub2XpSG9

Jul 13, 2022 · 10,309 followers View post →
John Hogenesch
@jbhclock · X

RT @Kottyan_Lab: The article discusses the implications of the research @jbhclock published in @PNASNews : "A circadian gene expression at…

Jul 6, 2022 · 1 share · 2,991 followers View post →
Leah Kottyan
@Kottyan_Lab · X

The article discusses the implications of the research @jbhclock published in @PNASNews : "A circadian gene expression atlas in mammals: Implications for biology and medicine" https://t.co/bFUqIUgLuQ

Jul 6, 2022 · 4 likes · 1 share · 707 followers View post →