The article discusses the implications of the research @jbhclock published in @PNASNews : "A circadian gene expression atlas in mammals: Implications for biology and medicine" https://t.co/bFUqIUgLuQ
A circadian gene expression atlas in mammals: implications for biology and medicine.
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Jul 2022 – Jun 2025Where it's discussed
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Discussions show a strong interest in the implications of the article, with bloggers emphasizing how many drugs target cycling genes and how timing treatments could improve outcomes, evidenced by phrases like 'many drugs target cycling genes' and 'should be investigated for enhanced outcomes.' The tone indicates engagement with its potential for impact on medicine and biology, reflecting a recognition of the research's transformative possibilities.
Most posts recognize the significance of the research, highlighting its relevance for medicine and drug timing strategies.
Discussions demonstrate high curiosity about how circadian gene data could influence treatments and biological understanding.
Posts include references to implications and future applications, showing thoughtful consideration.
Comments underscore the potential for medical advancements and personalized therapy based on the study's findings.
Abstract in brief
- The study used RNAseq and DNA arrays to analyze gene expression in 12 mouse organs over time, revealing that 43% of protein-coding genes show circadian rhythms, mostly peaking before dawn and dusk.
- Rhythmic genes tend to cluster, be longer, and have more splice variants, with an intricate, time-based regulation of gene pathways across the body, including many noncoding RNAs that are conserved between mice and humans.
- Most major drugs target products of rhythmic genes, suggesting that timing their administration (chronotherapy) could improve treatment effectiveness, emphasizing the importance of the circadian clock in both biological processes and medicine.]
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Most liked on X and Blueskyhttps://t.co/bImq6mVHhD
@owl_posting This goes beyond cancer too! Many drugs target cycling genes and should be investigated for enhanced outcomes based on dosage timing: https://t.co/UUT4MAj2sz
A circadian gene expression atlas in mammals: Implications for biology and medicine | Proceedings of the National Academy of Sciences https://t.co/9Pub2XpSG9
All mentions
Using Melatonin and Body Temperature to Track Human Circadian Rhythms
This short video introduces the 12 tools Chris and I use to maintain our active lifestyle. We explain the reliability of melatonin and body temperature as circadian markers and their relationship to sleep times. Please…
Using Melatonin and Temperature to Track Human Circadian Rhythms
This video explains how melatonin and core body temperature serve as markers for the human circadian clock and their relation to sleep times. Melatonin phases are more consistent and better correlate with actual sleep…
Using Melatonin and Body Temperature to Track Human Circadian Rhythms
This video explores the stability of melatonin levels and body temperature as circadian phase markers and their relationship to sleep times. Melatonin phases are more reliable indicators of circadian timing than…
Understanding Circadian Markers for Sleep and Wake Timing Analysis
This video explains the last four of the 12 tools used to maintain an active lifestyle, focusing on circadian phase markers like melatonin and core body temperature, and their relation to sleep times.
@owl_posting This goes beyond cancer too! Many drugs target cycling genes and should be investigated for enhanced outcomes based on dosage timing: https://t.co/UUT4MAj2sz
https://t.co/bImq6mVHhD
A circadian gene expression atlas in mammals: Implications for biology and medicine | Proceedings of the National Academy of Sciences https://t.co/9Pub2XpSG9
RT @Kottyan_Lab: The article discusses the implications of the research @jbhclock published in @PNASNews : "A circadian gene expression at…
The article discusses the implications of the research @jbhclock published in @PNASNews : "A circadian gene expression atlas in mammals: Implications for biology and medicine" https://t.co/bFUqIUgLuQ