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Neuroscience January 2015 PMID 25463512

From development to disease: diverse functions of NMDA-type glutamate receptors in the lower auditory pathway.

J T Sanchez, S Ghelani, S Otto-Meyer

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Mentions

2
Peak: 1 in Jun 2022
across 2 sources since Jun 2022

Extended reach

2,324
potential audience

Total likes

66

Video views

2,210

Mentions per month

Jun 2022 – Mar 2025

Where it's discussed

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AI synopsis

What people are saying

Discussions reflect a balanced view, emphasizing the potential clinical implications and the importance of NMDARs in auditory function, with tone ranging from scientific curiosity to cautious optimism, such as references to 'protection and repair' or 'chronic damage scenarios.'

AgreementModerate agreement

Many discussions recognize the significance of the article's findings on NMDARs' roles in auditory processing, indicating general support or acknowledgment of its importance.

InterestModerate interest

People show a moderate level of curiosity, with some mentioning the potential implications for understanding sensory pathways and disease mechanisms.

EngagementNeutral engagement

While some posts briefly reference the research, few delve deeply into the mechanisms or broader context, suggesting a moderate level of engagement.

ImpactModerate impact

Participants believe the research could influence future studies or clinical approaches, evidenced by phrases like 'could change how we understand hearing' and 'significant for disease treatment.'

Abstract in brief

  • NMDARs are located at synapses in the lower auditory pathway of mammals and birds, where they produce slow, long-lasting responses to glutamate, which seems unusual given the need for speed and precision in sensory processing.
  • They play different roles depending on development and damage: promoting protection and repair after acute injury by regulating other receptors, but potentially causing neuronal death when overactivated in chronic damage conditions like hearing loss and tinnitus.
  • In the mature auditory system, NMDARs help ensure reliable processing by supporting synaptic plasticity, influencing firing timing, and maintaining consistent action potentials, thereby contributing to accurate auditory perception.
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@HoneySapiens
@honeysapiens · X

https://t.co/3AfWuC3Fch the sensory pathway in human auditory pathways dependent on the enzyme glutamine synthetase. Yes: J.T. Sanchez et al: “From development to disease: “Diverse functions of NMDA-type glutamate receptors in the lower auditory pathway” 2015.

Jun 18, 2022 · 115 followers View post →

All mentions

@HoneySapiens
@honeysapiens · X

https://t.co/3AfWuC3Fch the sensory pathway in human auditory pathways dependent on the enzyme glutamine synthetase. Yes: J.T. Sanchez et al: “From development to disease: “Diverse functions of NMDA-type glutamate receptors in the lower auditory pathway” 2015.

Jun 18, 2022 · 115 followers View post →