Neurosci Biobehav Rev January 2015 PMID 25464029

Stress-induced perinatal and transgenerational epigenetic programming of brain development and mental health.

Olena Babenko, Igor Kovalchuk, Gerlinde A S Metz

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11
Peak: 2 in Sep 2025
across 4 sources since Feb 2015

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Feb 2015 – Sep 2025

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What people are saying

Discussions emphasize the significance of the research in understanding how prenatal stress affects mental health, with posts referencing related studies and keywords like 'epigenetics' and 'anxiety.' The tone shows curiosity and acknowledgment of the broader implications, highlighting the importance of addressing early life stress for future health outcomes.

AgreementModerate agreement

Most discussions agree with or highlight the importance of the research, referencing additional studies and relevant keywords.

InterestHigh interest

Comments show high interest, especially with mentions of other studies and emphasizing the significance of the findings.

EngagementModerate engagement

Posts demonstrate thoughtful engagement, discussing implications and suggesting further exploration of related research.

ImpactHigh impact

Users recognize the potential impact of the article for understanding stress and mental health, considering it relevant to real-world issues.

Abstract in brief

  • Stress during pregnancy can have long-lasting effects on both maternal and offspring mental health by altering epigenetic mechanisms such as DNA methylation, miRNA expression, and histone modifications.
  • These epigenetic changes, caused by stressful experiences in utero or early life, might influence brain development and increase the risk of neuropsychiatric disorders like schizophrenia, ADHD, autism, anxiety, and depression across generations.
  • Recognizing the role of transgenerational epigenetic inheritance emphasizes the importance of addressing prenatal and ancestral stress to improve lifelong health outcomes and develop better intervention strategies.

Top posts

Most liked on X and Bluesky
DrRPalmquist
@DrPalmquist · X

Stress-induced perinatal and transgenerational epigenetic programming of brain development and mental health - PubMed https://t.co/4ejiv2P4nL

Mar 16, 2022 · 3,164 followers View post →
ً
@cvlt_l34d3r · X

@goodbyefriend https://t.co/TzDzbKLBU7 (perinatal and early life stress) https://t.co/2oeocOpfRD there are a lot of other studies you can find by yourself on pubmed by adding the keywords "stress" "epigenetics" "anxiety" "PTSD" etc. It could explain a lot of what we're going through

Oct 27, 2023 · 2,820 followers View post →

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everliis
@everlyys · X

@StellarFox16 Anyone who doubts this, please see https://t.co/7lTUPT4tcv and https://t.co/MrvnxMJ1Sr and https://t.co/06pnp1g56o as well as https://t.co/upESY7JEBT

Mar 29, 2025 · 31 followers View post →
ً
@cvlt_l34d3r · X

@goodbyefriend https://t.co/TzDzbKLBU7 (perinatal and early life stress) https://t.co/2oeocOpfRD there are a lot of other studies you can find by yourself on pubmed by adding the keywords "stress" "epigenetics" "anxiety" "PTSD" etc. It could explain a lot of what we're going through

Oct 27, 2023 · 2,820 followers View post →
DrRPalmquist
@DrPalmquist · X

Stress-induced perinatal and transgenerational epigenetic programming of brain development and mental health - PubMed https://t.co/4ejiv2P4nL

Mar 16, 2022 · 3,164 followers View post →
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