December 2014 PMID 25484259

An integrative analysis reveals coordinated reprogramming of the epigenome and the transcriptome in human skeletal muscle after training.

Maléne E Lindholm, Francesco Marabita, David Gomez-Cabrero, Helene Rundqvist, Tomas J Ekström, Jesper Tegnér, Carl Johan Sundberg

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Mentions

159

Peak: 3 in Jul 2020

across 5 sources since Jan 2019

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1,847,524

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4,471

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Jan 2019 – Oct 2025

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AI synopsis

What people are saying

The overall tone reflects interest and recognition of the scientific significance, with comments like 'echt gut erklärt' and mentions of gene influence, emphasizing the importance of understanding epigenetic changes in muscle training. The tone varies from casual curiosity to brief technical observations, indicating curiosity and moderate engagement with the topic's broader implications.

AgreementModerate agreement

Most comments acknowledge the scientific validity and importance of the research, with some questioning aspects of gene influence and the novelty of findings.

InterestModerate interest

Discussions show a moderate level of curiosity, especially with summaries of the study and its implications, but some comments are basic or casual.

EngagementModerate engagement

Participants reference specific elements like molecular processes and broader implications, indicating a decent level of engagement without deep technical analysis.

ImpactModerate impact

The posts suggest the findings are viewed as impactful, highlighting how training influences muscle at the molecular level, though some express curiosity rather than certainty about long-term effects.

Abstract in brief

The study finds that endurance exercise training causes significant changes in the epigenome (DNA methylation) and gene expression in human skeletal muscle, which are linked to muscle remodeling and energy use.
These epigenetic and transcriptomic changes are influenced by factors like gender and are mainly seen in enhancer regions and gene bodies rather than promoters, involving key transcription factors like MRF, MEF2, and ETS.
The research highlights that these molecular changes are coordinated and likely contribute to the physical and health benefits of training, acting as an important link between environmental stimuli and genetic regulation.]

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Epigenetics and Gene Influence: How Environment Shapes Our DNA

Ralph Caspers explores whether epigenetics can influence our genes and if these changes are inheritable. Epigenetics involves mechanisms that regulate gene activity through DNA packaging, affected by environmental…

Quarks Dimension Ralph · Dec 12, 2023 284,933 views

Epigenetic and Transcriptomic Changes in Skeletal Muscle After Training

Endurance exercise induces significant epigenetic and gene expression alterations in human skeletal muscle, promoting muscle remodeling and energy utilization. These changes involve enhancer regions and key…

Sergey Novikov - мужской канал уролога · Dec 17, 2022 1,577 views

✌ Silva Arnemann

@SilvaAtTwitta · X

Epigenetik: Wie kann ich meine Gene beeinflussen? https://t.co/Ak06E3mjPn

Oct 26, 2025 · 1 like · 1,251 followers View post →

✌ Silva Arnemann

@SilvaAtTwitta · X

Aber die KIWI!!11! Entschuldigung https://t.co/Ak06E3lLZP

Oct 25, 2025 · 1,251 followers View post →

ottersnoot

@ottersnoot · X

https://t.co/J70I83liCZ Das ist echt gut erklärt. Ich frage mich ob man Verwandtschaft nicht neu definieren sollte denn man muss nicht aus derselben Person gekrochen sein um dieselbe Gene zu haben und vor allem wenn es um das Gehirn geht fühlt man sich dann doch zu ähnlichen

Dec 12, 2023 · 4 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Mar 22, 2023 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Mar 8, 2023 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Feb 19, 2023 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Feb 6, 2023 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Jan 23, 2023 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Jan 11, 2023 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Dec 27, 2022 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Dec 12, 2022 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Nov 25, 2022 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7TnM

Nov 14, 2022 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9OuPK9E

Nov 2, 2022 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Oct 19, 2022 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Oct 2, 2022 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7TnM

Sep 19, 2022 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Sep 2, 2022 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Aug 22, 2022 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Aug 9, 2022 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Jun 8, 2022 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

May 27, 2022 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

May 11, 2022 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

May 1, 2022 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Apr 14, 2022 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Mar 31, 2022 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Mar 21, 2022 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Mar 6, 2022 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Feb 17, 2022 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Feb 6, 2022 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Jan 23, 2022 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Jan 8, 2022 · 1 like · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Dec 22, 2021 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Dec 9, 2021 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Nov 24, 2021 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Nov 10, 2021 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Nov 1, 2021 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Oct 18, 2021 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Oct 4, 2021 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Sep 17, 2021 · 1 like · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Sep 3, 2021 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Aug 17, 2021 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Aug 8, 2021 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Jul 21, 2021 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Jul 13, 2021 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Jun 28, 2021 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Jun 11, 2021 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

May 26, 2021 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

May 15, 2021 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

May 2, 2021 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Apr 16, 2021 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Apr 5, 2021 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Mar 21, 2021 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Mar 2, 2021 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Feb 16, 2021 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Feb 7, 2021 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Jan 24, 2021 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Jan 8, 2021 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Dec 25, 2020 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Dec 11, 2020 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Nov 27, 2020 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Nov 1, 2020 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Oct 19, 2020 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Oct 8, 2020 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Sep 11, 2020 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Aug 24, 2020 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Aug 14, 2020 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Jul 30, 2020 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Jul 18, 2020 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Jul 10, 2020 · 22,790 followers View post →

Mortar & Pestle

@MortarPestleUSA · X

Integrative Analysis Reveals Coordinated Reprogramming of Epigenome & Transcriptome in Human Muscle After Training: https://t.co/Wps9Ov7lye

Jun 24, 2020 · 22,790 followers View post →

SeqComplete

@SeqComplete · X

An integrative analysis reveals coordinated reprogramming of the epigenome and the transcriptome in human skeletal muscle after training. - PubMed - NCBI https://t.co/c6hJ5ZauPh

Jan 14, 2019 · 4,395 followers View post →

SeqComplete

@SeqComplete · X

An integrative analysis reveals coordinated reprogramming of the epigenome and the transcriptome in human skeletal muscle after training. - PubMed - NCBI https://t.co/c6hJ5ZauPh

Jan 6, 2019 · 4,395 followers View post →

An integrative analysis reveals coordinated reprogramming of the epigenome and the transcriptome in human skeletal muscle after training.

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Abstract in brief

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All mentions

Epigenetics and Gene Influence: How Environment Shapes Our DNA

Epigenetic and Transcriptomic Changes in Skeletal Muscle After Training