Neuropsychopharmacology May 2015 PMID 25533534

The sleep-promoting and hypothermic effects of glycine are mediated by NMDA receptors in the suprachiasmatic nucleus.

Nobuhiro Kawai, Noriaki Sakai, Masashi Okuro, Sachie Karakawa, Yosuke Tsuneyoshi, Noriko Kawasaki, Tomoko Takeda, Makoto Bannai, Seiji Nishino

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Mentions

72
Peak: 6 in Jan 2023
across 7 sources since Jul 2020

Extended reach

190,626
potential audience

Total likes

102

Video views

831

Mentions per month

Jul 2020 – Oct 2025

Where it's discussed

  • News34 articles
  • X / Twitter21 posts
  • Facebook6 posts
  • Blogs5 articles
  • YouTube3 videos
  • Reddit2 posts
  • Bluesky1 posts

AI synopsis

What people are saying

The social discussions show enthusiasm supported by scientific references, such as mentions of how glycine influences sleep and is mediated by NMDA receptors, with users expressing curiosity and sharing personal experiences. The tone combines scientific interest with personal relevance, indicating active engagement with the research's implications.

AgreementStrong agreement

Most discussions express strong support and validation for the findings, with several posts citing research and personal experiences that align with the publication.

InterestHigh interest

Posts demonstrate high curiosity and enthusiasm, with users asking about mechanisms and potential applications like sleep improvement and mental health conditions.

EngagementModerate engagement

Several comments reference scientific concepts such as NMDA receptors and the SCN, engaging deeply with the research, though some are more reflective or anecdotal.

ImpactModerate impact

The discussions highlight potential significance for sleep treatments and mental health issues, though it remains partly speculative and based on preliminary evidence.

Abstract in brief

  • Glycine promotes sleep and lowers body temperature mainly by acting on NMDA receptors in the suprachiasmatic nucleus (SCN) of the brain, leading to increased blood flow and heat loss.
  • The sleep-enhancing and hypothermic effects of glycine are prevented by NMDA receptor antagonists, indicating that these receptors are crucial for its action, while blocking glycine receptors does not have the same effect.
  • Injecting glycine directly into the SCN increases blood flow and aids sleep, and removing the SCN completely stops glycine's sleep and temperature effects, confirming the SCN's key role in mediating glycine's benefits.]

Top posts

Most liked on X and Bluesky
Heewon Jung
@DrEcsta · X

불면을 겪을 때에 시도는 한 번 해 볼 만 할 것 같습니다. Aging Cell (2019) Jun;18(3):e12953. doi: 10.1111/acel.12953 Open Heart (2014) 1:e000103. doi:10.1136/openhrt-2014-000103 Neuropsychopharmacology (2015) 40, 1405–1416; doi:10.1038/npp.2014.326

Jan 21, 2023 · 29 likes · 9 shares · 127,436 followers View post →
Naomi Harvey PhD #WearAMask
@Naomi_D_Harvey · X

Some research suggests that glycine supplements may improve sleep in people with insomnia, which is also a big problem in #pwME and #LongCovid https://t.co/qgS7k3NMDl

Jan 3, 2023 · 12 likes · 5 shares · 16,577 followers View post →
NV ENVY?
@VilNateDog · X

@Babygravy9 Glycine helps immensely for me, collagen powder is high in glycine https://t.co/z0vCAJxFES

Jun 6, 2023 · 8 likes · 176 followers View post →
Ally Houston
@AllyTransforms · X

Promising glycine results for: OCD: https://t.co/Xmf24hhacV Schizophrenia: https://t.co/SE5JSnclrM Sleep: https://t.co/703pUIzQof For more on these amino acids, see @fire_bottle videos e.g. https://t.co/2T5zHZsc8E 5/6

Jan 6, 2024 · 7 likes · 5,815 followers View post →
UltimApe
@ultimape · X

Was just exploring the same space in the brain WRT impacts of glycine and gaba on sleep. "The Sleep-Promoting and Hypothermic Effects of Glycine are Mediated by NMDA Receptors in the Suprachiasmatic Nucleus" https://t.co/ThfeshCfnR https://t.co/KBho3kEctI

Jul 15, 2020 · 3 likes · 6,687 followers View post →
NV ENVY?
@VilNateDog · X

@hubermanlab Glycine works very well in my experience https://t.co/z0vCAJyduq

Jan 19, 2025 · 2 likes · 176 followers View post →

All mentions

Rene Sugar
@renesugar · X

@saffronandsky Glycine Stimulates Protein Synthesis and Inhibits Oxidative Stress ... https://t.co/ihgS9umCGd 3g / day: The Sleep-Promoting and Hypothermic Effects of Glycine are Mediated by NMDA Receptors in the Suprachiasmatic Nucleus https://t.co/1VQUw3NnQp.

Oct 7, 2025 · 3,970 followers View post →
Awakened Princess
@GastricpH · X

Not

Sep 6, 2025 · 1,015 followers View post →
-
@ja_apple1284 · X

RT @DrEcsta: 불면을 겪을 때에 시도는 한 번 해 볼 만 할 것 같습니다. Aging Cell (2019) Jun;18(3):e12953. doi: 10.1111/acel.12953 Open Heart (2014) 1:e000103. do…

Feb 22, 2025 · 9 shares · 200 followers View post →
NV ENVY?
@VilNateDog · X

@hubermanlab Glycine works very well in my experience https://t.co/z0vCAJyduq

Jan 19, 2025 · 2 likes · 176 followers View post →
xlefr dada-son
@kristleifur.bsky.social · Bluesky

Things I’m curious about: If sub-clinical nutrient deficiencies aren’t one of the issues. (Like, say, roughly: if our microbiota are overly simple and proteins aren’t broken down into amino acids quite as well as we’d like?

Jun 21, 2024 · 1 share View post →
奎圓
@TheatreQ · X

RT @DrEcsta: 불면을 겪을 때에 시도는 한 번 해 볼 만 할 것 같습니다. Aging Cell (2019) Jun;18(3):e12953. doi: 10.1111/acel.12953 Open Heart (2014) 1:e000103. do…

Apr 14, 2024 · 9 shares · 998 followers View post →
Oui
@Oui_0705 · X

RT @DrEcsta: 불면을 겪을 때에 시도는 한 번 해 볼 만 할 것 같습니다. Aging Cell (2019) Jun;18(3):e12953. doi: 10.1111/acel.12953 Open Heart (2014) 1:e000103. do…

Apr 14, 2024 · 9 shares · 3 followers View post →
수선화H
@kanggyoungsuk · X

RT @DrEcsta: 불면을 겪을 때에 시도는 한 번 해 볼 만 할 것 같습니다. Aging Cell (2019) Jun;18(3):e12953. doi: 10.1111/acel.12953 Open Heart (2014) 1:e000103. do…

Apr 14, 2024 · 9 shares · 1,165 followers View post →
Misty
@MistyNotaBot · X

RT @Naomi_D_Harvey: Some research suggests that glycine supplements may improve sleep in people with insomnia, which is also a big problem…

Feb 15, 2024 · 5 shares · 347 followers View post →
8Eevert ✨
@8Eevert · X

@phantom_opus @ChrisMasterjohn > Is this related to why 3g glycine before bed helps my sleep quality? I’ve believed it to be related to the role Glycine has in NMDAR function: “The #Sleep-Promoting and Hypothermic Effects of #Glycine Are Mediated by NMDA Receptors in the Suprachiasmatic Nucleus.” https://t.co/M9mZRZn2q3

Jan 9, 2024 · 1,150 followers View post →
Ally Houston
@AllyTransforms · X

Promising glycine results for: OCD: https://t.co/Xmf24hhacV Schizophrenia: https://t.co/SE5JSnclrM Sleep: https://t.co/703pUIzQof For more on these amino acids, see @fire_bottle videos e.g. https://t.co/2T5zHZsc8E 5/6

Jan 6, 2024 · 7 likes · 5,815 followers View post →
jabe biquet
@enigmasum · X

RT @enigmasum: The Sleep-Promoting and Hypothermic Effects of Glycine are Mediated by NMDA Receptors in the Suprachiasmatic Nucleus https:…

Oct 4, 2023 · 1 share · 10,583 followers View post →
jabe biquet
@enigmasum · X

The Sleep-Promoting and Hypothermic Effects of Glycine are Mediated by NMDA Receptors in the Suprachiasmatic Nucleus https://t.co/CwSeMPmlWi

Oct 3, 2023 · 1 share · 10,583 followers View post →
NV ENVY?
@VilNateDog · X

@Babygravy9 Glycine helps immensely for me, collagen powder is high in glycine https://t.co/z0vCAJxFES

Jun 6, 2023 · 8 likes · 176 followers View post →
5대수
@AprilMay454545 · X

RT @DrEcsta: 불면을 겪을 때에 시도는 한 번 해 볼 만 할 것 같습니다. Aging Cell (2019) Jun;18(3):e12953. doi: 10.1111/acel.12953 Open Heart (2014) 1:e000103. do…

Jan 21, 2023 · 9 shares · 286 followers View post →
타히티꿈의바다
@luckystrongrab8 · X

RT @DrEcsta: 불면을 겪을 때에 시도는 한 번 해 볼 만 할 것 같습니다. Aging Cell (2019) Jun;18(3):e12953. doi: 10.1111/acel.12953 Open Heart (2014) 1:e000103. do…

Jan 21, 2023 · 9 shares · 83 followers View post →
Heewon Jung
@DrEcsta · X

불면을 겪을 때에 시도는 한 번 해 볼 만 할 것 같습니다. Aging Cell (2019) Jun;18(3):e12953. doi: 10.1111/acel.12953 Open Heart (2014) 1:e000103. doi:10.1136/openhrt-2014-000103 Neuropsychopharmacology (2015) 40, 1405–1416; doi:10.1038/npp.2014.326

Jan 21, 2023 · 29 likes · 9 shares · 127,436 followers View post →
8Eevert ✨
@8Eevert · X

RT @Naomi_D_Harvey: Some research suggests that glycine supplements may improve sleep in people with insomnia, which is also a big problem…

Jan 4, 2023 · 5 shares · 1,150 followers View post →
MPonds
@PondsMA · X

RT @Naomi_D_Harvey: Some research suggests that glycine supplements may improve sleep in people with insomnia, which is also a big problem…

Jan 3, 2023 · 5 shares · 73 followers View post →
Naomi Harvey PhD #WearAMask
@Naomi_D_Harvey · X

Some research suggests that glycine supplements may improve sleep in people with insomnia, which is also a big problem in #pwME and #LongCovid https://t.co/qgS7k3NMDl

Jan 3, 2023 · 12 likes · 5 shares · 16,577 followers View post →
8Eevert ✨
@8Eevert · X

@artistAuDH Curiously, to me, the direct effects of both are mediated via NMDA: > Mg is an NMDA antagonist and a GABA agonist, which have a relaxant effect https://t.co/wzZKIVIHX0 > glycine promotes sleep via peripheral vasodilatation through the activation of NMDAR https://t.co/n62YdCanUs

Dec 14, 2022 · 1,150 followers View post →
UltimApe
@ultimape · X

Was just exploring the same space in the brain WRT impacts of glycine and gaba on sleep. "The Sleep-Promoting and Hypothermic Effects of Glycine are Mediated by NMDA Receptors in the Suprachiasmatic Nucleus" https://t.co/ThfeshCfnR https://t.co/KBho3kEctI

Jul 15, 2020 · 3 likes · 6,687 followers View post →