Circ Res January 2015 PMID 25552691

Reproducibility in science: improving the standard for basic and preclinical research.

C Glenn Begley, John P A Ioannidis

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Mentions

59
Peak: 3 in May 2022
across 5 sources since Apr 2019

Extended reach

210,616
potential audience

Total likes

4,467

Video views

187,659

Mentions per month

Apr 2019 – Sep 2025

Where it's discussed

  • X / Twitter23 posts
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  • Facebook4 posts
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AI synopsis

What people are saying

Discussions demonstrate strong agreement with the article, as seen in comments referencing notable researchers like Ioannidis and Begley, and concern about research sloppiness, with words like 'crisis' and 'irreproducibility' emphasizing significance. The tone combines critical analysis with recognition of systemic issues, reflecting deep engagement and perceived impact on scientific practices.

AgreementModerate agreement

Most discussions acknowledge the reproducibility crisis and the importance of the article, showing general support for addressing scientific reliability.

InterestHigh interest

Participants are highly engaged, referencing multiple studies, experts, and debates about research practices.

EngagementModerate engagement

Several contributors critically analyze research quality, quoting specific studies and authors, indicating meaningful engagement.

ImpactModerate impact

The conversations highlight the potential influence of the article on scientific standards and public trust, with mentions of widespread issues and reforms.

Abstract in brief

  • Scientific progress depends on reliable and robust data, but there is a growing "reproducibility crisis" in biomedical research, where many findings may not be replicable.
  • This issue is partly due to poor adherence to good scientific practices and the "publish or perish" culture that pressures researchers to produce new results quickly.
  • Addressing this complex problem requires combined efforts from all stakeholders involved in the research process, along with potential solutions aimed at improving research quality and reproducibility.

Top posts

Most liked on X and Bluesky
Cristina Rodríguez-Prada
@crodriguezprada · X

La investigación es una actividad humana que no ocurre en el vacío. Por ello es importante analizar el contexto en el que se desarrolla: si es uno que incentiva prácticas cuestionables, lo normal es que así las obtengamos https://t.co/xqpOEeGNoW https://t.co/WYiuagjAjp

Apr 21, 2022 · 5 likes · 476 followers View post →
Miss Information
@MargoCa26504030 · X

@KenSycspng @LordPerkins @buddha3321 @StephenNRA2 @KVandetti Like Dr's: Ryan Cole Robert Malone Peter McCullough Paul Marik Pierre Kory etc etc etc AND Is this the data you claim to be reviewing? 'Irreproducibility based on these empirical observations range from 75% to 90%' Irreproducibility = is this info correct? https://t.co/OlPMXKXGuE

Aug 28, 2022 · 1 like · 566 followers View post →
Why is Nurse Tiffany Dover Missing?
@JamieConner8 · X

@immunotoxPhD @Boxmenot @BeckyJohnson222 @lex6m @doritmi @ladybugobgyn @Plasticdoe @Raelove65451372 @CoercedTaxSlave @bruce_barrett @RogueTrader84 @GansenJared @KrochetxKorner @TYLERG927 @Anguish4ever @PileOfGoop @MsTrixter @VeritasEver @mcfunny @Siubhan_H @bobsnee @kmerian @ianfmusgrave @StopVaxxedLies @Sohnhicc @EmmaGPaley @45HammerTime @Nukem37 @amanda_pompili @t3tragrammat0n @kidoctr @TeddyFreddy11 @erikwilson1975 @Notyour28981739 @jjay_1984 @Stephaniethe2nd @BigTheyInc @Golfergirl2018 @DCataneo @SkepticalMutant @MAhealthforkids @JulieAMcLean @weaponizedword1 @kuriousmind93 @milnem @begarcia87 @laurast30381821 @Just4TheCause @michabird67 @KittyAmnezia 'concerns have been expressed for observational research where zero of 52 predictions from observational studies were confirmed in randomized clinical trials'. https://t.co/lAPL1akLKW

Apr 29, 2019 · 1 like · 285 followers View post →
Julie Babyar
@juliebabyar · X

@tandfonline Thanks. Also, it's well known that the experimental unit, measure or other defined term for unit of analysis is often incorrectly identified, translating to incorrect analytics. https://t.co/mC2ue7KXHj https://t.co/QUegZul9bi https://t.co/IcHW5Ldvzj https://t.co/XGG5KMu7gX

Feb 1, 2022 · 9,253 followers View post →
Social Media Freed the World
@VittoJC · X

@BerryTartlet @TheChiefNerd @P_McCulloughMD Plus there is a crisis of sloppiness in peer reviewed research. https://t.co/pwj60NQHDc

Apr 1, 2023 · 2,488 followers View post →
Yvan Dutil
@YvanDutil · X

@YannBECKER4 @ThomasMoore112 @podz4 @gcomeaudotcom @jeanbarbeau2 @SebMarinMD Pêle-mêle. https://t.co/bEk67tdKSx https://t.co/EOICFW0PZy https://t.co/W0mKIOwA4b https://t.co/gRREvXRdXw https://t.co/WpwyWzuMKW https://t.co/Nb6MItzOuz https://t.co/cwpLaeyg8c https://t.co/kwWfkLCSjw

Jun 3, 2023 · 2,266 followers View post →

All mentions

Bare-Faced Plague Spreader
@bfacedplague · X

@brianartese @simonmaechling https://t.co/2THCx0dLY2

Sep 5, 2025 · 1,600 followers View post →
efdavis
@efdavis419 · X

@kevinnbass Very important to put this research in context, which the poster fails to do. There is no 28 billion of taxpayer waste proven anywhere. See quote and citation below from Begley, et al https://t.co/ihEXsxp7Hh https://t.co/PablJeaEP2

Jul 15, 2025 · 439 followers View post →
LinkToGo
@linktogo · X

@pmarca John Ioannidis had something to say about this a while back https://t.co/U7sAvhIAxy

Nov 7, 2024 · 121 followers View post →
John
@John007KL · X

@Eudaimon_Sporos @FtimaMonterros3 @AKN4710 Nunca lo fue, verdad? Ten una muestra de la realidad del mundo de las publicaciones "cientificas" y sus conclusiones cientificas. https://t.co/ZRnLKlrnlp https://t.co/BoLhGvhKA9 https://t.co/Y0maJbNXtt https://t.co/ELMKmzqrdW

Jun 15, 2023 · 17 followers View post →
Yvan Dutil
@YvanDutil · X

@YannBECKER4 @ThomasMoore112 @podz4 @gcomeaudotcom @jeanbarbeau2 @SebMarinMD Pêle-mêle. https://t.co/bEk67tdKSx https://t.co/EOICFW0PZy https://t.co/W0mKIOwA4b https://t.co/gRREvXRdXw https://t.co/WpwyWzuMKW https://t.co/Nb6MItzOuz https://t.co/cwpLaeyg8c https://t.co/kwWfkLCSjw

Jun 3, 2023 · 2,266 followers View post →
Peter Zegers
@peterzegers · X

@ReginaJ50039402 @iusethisonline @LeorSapir @TM0s41 @profjmb @MattiasDeSmet Did you read the article by Ioannidis? "[I]t is important to note at the outset that these concerns about the irreproducibility of science do not invalidate the validity or legitimacy of the scientific method." https://t.co/wq3027A6xV

May 18, 2023 · 314 followers View post →
Social Media Freed the World
@VittoJC · X

@BerryTartlet @TheChiefNerd @P_McCulloughMD Plus there is a crisis of sloppiness in peer reviewed research. https://t.co/pwj60NQHDc

Apr 1, 2023 · 2,488 followers View post →
MedicalEvidence
@massiMedical · X

https://t.co/8w7NTFrqLp

Jan 30, 2023 · 50 followers View post →
Progressive Veterinary Association
@pvavet · X

In case you missed this in 2015. The unseen reproducibility crisis in basic and preclinical research (especially relevant to animal experiments) https://t.co/6BKvGw6HWa https://t.co/FVj7Wqr9L7

Jan 3, 2023 · 111 followers View post →
R137K
@R137K · X

@mboudry Serieus?Die Nassir Gaemi kletst hier uit zijn nek, de correcte studie aanhalen waarnaar in het boek wordt verwezen was zelf te hoog gegrepen voor die man. Wat een fantast. https://t.co/4MbbDdm9Vn https://t.co/qIf8KDOch6

Oct 28, 2022 · 529 followers View post →
Miss Information
@MargoCa26504030 · X

@KenSycspng @LordPerkins @buddha3321 @StephenNRA2 @KVandetti Like Dr's: Ryan Cole Robert Malone Peter McCullough Paul Marik Pierre Kory etc etc etc AND Is this the data you claim to be reviewing? 'Irreproducibility based on these empirical observations range from 75% to 90%' Irreproducibility = is this info correct? https://t.co/OlPMXKXGuE

Aug 28, 2022 · 1 like · 566 followers View post →
Gorazd Korošec
@Gorazd_Korosec · X

@SalamonSMD @MatjazLeskovar @PeterMalovrh Vir: C. Glenn Begley and John P. Ioannidis, "Reproducibility in Science: Improving the Standard for Basic and Preclinical Research", Circulation Research 116, no. 1 (January 2015): 116–26, https://doi .org/10.1161/CIRCRESAHA.114.303819

Jul 27, 2022 · 211 followers View post →
tokatti
@tokatti_ · X

一般ウケしやすい文献が積極的に発表されがち パッとしないデータは公表されないケースが多め 統計の数値を割りといじりやすい みたいな問題がある https://t.co/zw0INO5lcz #自分用メモ

Jul 11, 2022 · 189 followers View post →
Wim Schuller
@toegangtotrecht · X

@veen_els @leondewinter

Jun 2, 2022 · 860 followers View post →
Wim Schuller
@toegangtotrecht · X

@WybrenvanHaga Is de kwaliteit (#waarheidsspreken) van de studies dan niet nergens problematischer dan in de #medische wetenschap, zoals o.m. de 3 hieronder genoemde studies uitwezen? #replicatiecrisis #Fanelli #Ionnidis https://t.co/E96l8wPerL https://t.co/b4uiHeQEWx https://t.co/heZjUlkDVt

May 26, 2022 · 860 followers View post →
Wim Schuller
@toegangtotrecht · X

@MarionKoopmans @_knaw @RHDijkgraaf @vanranstmarc @erasmusuni Is de kwaliteit (#waarheidsspreken) van de studies dan niet nergens problematischer dan in de #medische wetenschap, zoals o.m. de 3 hieronder genoemde studies uitwezen? #replicatiecrisis #Fanelli #Ionnidis https://t.co/E96l8wPerL https://t.co/b4uiHeQEWx https://t.co/heZjUlkDVt

May 25, 2022 · 860 followers View post →
Robert E. Juliano
@julianorobertrj · X

@StatsInTheWild Not separate issues (see enclosed on reproducibility concerns in biomedical research). https://t.co/NghdcXH6iI Plenty of additional articles available on the problems of reproducibility and medicine (e.g., the Lancet and NEJM retraction 2 years ago). https://t.co/UzcEHKtJyP

May 2, 2022 · 649 followers View post →
Cristina Rodríguez-Prada
@crodriguezprada · X

La investigación es una actividad humana que no ocurre en el vacío. Por ello es importante analizar el contexto en el que se desarrolla: si es uno que incentiva prácticas cuestionables, lo normal es que así las obtengamos https://t.co/xqpOEeGNoW https://t.co/WYiuagjAjp

Apr 21, 2022 · 5 likes · 476 followers View post →
Yuuki Reads
@YuukiReads · X

Does the desperation to publish or perish create irreproducible results?https://t.co/PiNuKEVdEt

Feb 18, 2022 · 3 followers View post →
Julie Babyar
@juliebabyar · X

@tandfonline Thanks. Also, it's well known that the experimental unit, measure or other defined term for unit of analysis is often incorrectly identified, translating to incorrect analytics. https://t.co/mC2ue7KXHj https://t.co/QUegZul9bi https://t.co/IcHW5Ldvzj https://t.co/XGG5KMu7gX

Feb 1, 2022 · 9,253 followers View post →
Romanes Eunt Domus
@FiliusDeo · X

@CubeSteve @CDogmatics @LustfulLiberal Nobody asserted a conspiracy. But if you like peer-reviewed journals with evidence as your authority for trust, you’re in luck! https://t.co/Xs8ltli1oa https://t.co/SxEQdaXZtv https://t.co/mhvY24feVL https://t.co/2mCgVEN49O

Apr 27, 2021 · 58 followers View post →
Miles (Thor) Morales
@nomamao · X

@El_Busby @JacobPoliticsKy @candleworth77 @ng0___ @TPUldi @Lars9596 @RealCandaceO @willtravers https://t.co/gaY9CaTVyK

Sep 22, 2019 · 752 followers View post →
Why is Nurse Tiffany Dover Missing?
@JamieConner8 · X

@immunotoxPhD @Boxmenot @BeckyJohnson222 @lex6m @doritmi @ladybugobgyn @Plasticdoe @Raelove65451372 @CoercedTaxSlave @bruce_barrett @RogueTrader84 @GansenJared @KrochetxKorner @TYLERG927 @Anguish4ever @PileOfGoop @MsTrixter @VeritasEver @mcfunny @Siubhan_H @bobsnee @kmerian @ianfmusgrave @StopVaxxedLies @Sohnhicc @EmmaGPaley @45HammerTime @Nukem37 @amanda_pompili @t3tragrammat0n @kidoctr @TeddyFreddy11 @erikwilson1975 @Notyour28981739 @jjay_1984 @Stephaniethe2nd @BigTheyInc @Golfergirl2018 @DCataneo @SkepticalMutant @MAhealthforkids @JulieAMcLean @weaponizedword1 @kuriousmind93 @milnem @begarcia87 @laurast30381821 @Just4TheCause @michabird67 @KittyAmnezia 'concerns have been expressed for observational research where zero of 52 predictions from observational studies were confirmed in randomized clinical trials'. https://t.co/lAPL1akLKW

Apr 29, 2019 · 1 like · 285 followers View post →