Plant Biotechnol J September 2015 PMID 25572960

Engineering soya bean seeds as a scalable platform to produce cyanovirin-N, a non-ARV microbicide against HIV.

Barry R O'Keefe, André M Murad, Giovanni R Vianna, Koreen Ramessar, Carrie J Saucedo, Jennifer Wilson, Karen W Buckheit, Nicolau B da Cunha, Ana Claudia G Araújo, Cristiano C Lacorte, Luisa Madeira, James B McMahon, Elibio L Rech

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Mentions

25
Peak: 8 in Nov 2019
across 5 sources since Apr 2015

Extended reach

154,623
potential audience

Total likes

21

Video views

243

Mentions per month

Apr 2015 – Apr 2023

Where it's discussed

  • X / Twitter12 posts
  • Facebook8 posts
  • YouTube2 videos
  • News2 articles
  • Bluesky1 posts

AI synopsis

What people are saying

The discussions emphasize the social importance of affordable HIV microbicides, mentioning how large-scale soybean engineering could address viral resistance concerns and improve global health, with words like 'urgent,' 'important,' and 'promising' underscoring their perceived significance and engagement with the research's societal implications.

AgreementModerate agreement

Most discussions acknowledge the importance and potential of producing cyanovirin-N via soybeans for HIV prevention, showing general support.

InterestModerate interest

Participants show moderate interest, highlighting contexts like HIV in developing countries and emphasizing microbicide affordability, indicating engagement with socially relevant issues.

EngagementModerate engagement

Posts include references to research goals, potential health impacts, and broader social implications, demonstrating a moderate level of detailed discussion.

ImpactModerate impact

Discussions suggest that this approach could significantly improve access to HIV prevention tools in resource-limited settings, implying a notable potential impact.

Abstract in brief

  • The study focuses on genetically engineering soybeans to produce cyanovirinN (CVN), an antiviral protein that can prevent HIV entry into cells, aiming to make microbicides more affordable for resource-poor areas.
  • The researchers successfully produced active recombinant CVN in soybean seeds, with a yield of 350 micrograms per gram of dry seed, and confirmed its structure and activity relate closely to the natural protein.
  • Importantly, the standard industrial process used for soybean oil extraction does not reduce CVN's antiviral activity, enabling the simultaneous production of soybean oil and antiviral proteins in a cost-effective way for HIV prevention.

Top posts

Most liked on X and Bluesky
ABCiências
@ABCiencias · X

#DivulgaçãoCientífica • Um estudo do Instituto Nacional de Ciência e Tecnologia em Biologia Sintética, dirigido pelo Acadêmico Elibio Rech, torna possível a produção de microbicidas contra o HIV a preços acessíveis!

Nov 23, 2019 · 15 likes · 5 shares · 75,974 followers View post →
Elibio Rech
@Elibio_Rech · X

There is an urgent need to provide effective anti-HIV microbicides to resource-poor areas worldwide. It is vital to reduce the cost. Enginnering soybean seeds as scalable platform to produce cyanovirin-N, a microbicide against HIV (doi: 10.1111/pbi.12309). Pic: F. Bastos, Embrapa https://t.co/YaYHtDKPnR

Feb 13, 2019 · 2 likes · 1 share · 151 followers View post →
Research Square
@researchsquare · X

Of the 35 million people worldwide living with #HIV, over half of new infections occur in women in developing countries, so affordable preventatives are crucial. A @PlantBiotechJ study reveals a possible avenue to produce an affordable microbicide: https://t.co/Kq2sXUCpIh @UNAIDS https://t.co/2EgA2xvaUZ

May 18, 2021 · 1 like · 1 share · 16,579 followers View post →
augusto
@Diego7au · X

artigo científico: Engineering soya bean seeds as a scalable platform to produce cyanovirin-N, a non-ARV microbicide against HIV https://t.co/TsoCemcgn8

Apr 15, 2023 · 1 like · 84 followers View post →
Mayana Zatz
@Mayanazatz · X

RT @ABCiencias: #DivulgaçãoCientífica • Um estudo do Instituto Nacional de Ciência e Tecnologia em Biologia Sintética, dirigido pelo Acadêm…

Nov 23, 2019 · 5 shares · 19,598 followers View post →
Research Square
@researchsquare · X

Today is #WorldAIDSDay. Topical #microbicides, used to combat HIV, are mostly based on #antiretroviral (ARV) drugs, but viral resistance is a concern. A non-ARV, #cyanovirin-N, is promising, but large-scale production is too expensive. What can be done?: https://t.co/iSLH2RdW7i https://t.co/YKInT3s9EV

Dec 1, 2020 · 16,579 followers View post →

All mentions

augusto
@Diego7au · X

artigo científico: Engineering soya bean seeds as a scalable platform to produce cyanovirin-N, a non-ARV microbicide against HIV https://t.co/TsoCemcgn8

Apr 15, 2023 · 1 like · 84 followers View post →
Research Square
@researchsquare · X

Women in developing countries account for over half of new HIV infections worldwide. Topical microbicides are crucial preventative care for these women, and this @PlantBiotechJ study sought to find a way to make them more affordable: https://t.co/Kq2sXUCpIh #WorldAIDsDay https://t.co/VAUFbJiU5N

Dec 1, 2021 · 16,579 followers View post →
Research Square
@researchsquare · X

Of the 35 million people worldwide living with #HIV, over half of new infections occur in women in developing countries, so affordable preventatives are crucial. A @PlantBiotechJ study reveals a possible avenue to produce an affordable microbicide: https://t.co/Kq2sXUCpIh @UNAIDS https://t.co/2EgA2xvaUZ

May 18, 2021 · 1 like · 1 share · 16,579 followers View post →
Research Square
@researchsquare · X

Today is #WorldAIDSDay. Topical #microbicides, used to combat HIV, are mostly based on #antiretroviral (ARV) drugs, but viral resistance is a concern. A non-ARV, #cyanovirin-N, is promising, but large-scale production is too expensive. What can be done?: https://t.co/iSLH2RdW7i https://t.co/YKInT3s9EV

Dec 1, 2020 · 16,579 followers View post →
Caetano Costa
@caetanocosta21 · X

RT @ABCiencias: #DivulgaçãoCientífica • Um estudo do Instituto Nacional de Ciência e Tecnologia em Biologia Sintética, dirigido pelo Acadêm…

Nov 23, 2019 · 5 shares · 217 followers View post →
Paulo Cesar Hopner
@pchopner · X

RT @ABCiencias: #DivulgaçãoCientífica • Um estudo do Instituto Nacional de Ciência e Tecnologia em Biologia Sintética, dirigido pelo Acadêm…

Nov 23, 2019 · 5 shares · 4,256 followers View post →
Mayana Zatz
@Mayanazatz · X

RT @ABCiencias: #DivulgaçãoCientífica • Um estudo do Instituto Nacional de Ciência e Tecnologia em Biologia Sintética, dirigido pelo Acadêm…

Nov 23, 2019 · 5 shares · 19,598 followers View post →
Emilia Andrade Belitardo
@MilaBelitardo · X

RT @ABCiencias: #DivulgaçãoCientífica • Um estudo do Instituto Nacional de Ciência e Tecnologia em Biologia Sintética, dirigido pelo Acadêm…

Nov 23, 2019 · 5 shares · 1,084 followers View post →
ZonbieSummerboy
@antunesLord · X

RT @ABCiencias: #DivulgaçãoCientífica • Um estudo do Instituto Nacional de Ciência e Tecnologia em Biologia Sintética, dirigido pelo Acadêm…

Nov 23, 2019 · 5 shares · 801 followers View post →
ABCiências
@ABCiencias · X

#DivulgaçãoCientífica • Um estudo do Instituto Nacional de Ciência e Tecnologia em Biologia Sintética, dirigido pelo Acadêmico Elibio Rech, torna possível a produção de microbicidas contra o HIV a preços acessíveis!

Nov 23, 2019 · 15 likes · 5 shares · 75,974 followers View post →
Mauricio A. Lopes
@Science4Future · X

RT @Elibio_Rech: There is an urgent need to provide effective anti-HIV microbicides to resource-poor areas worldwide. It is vital to reduce…

Feb 13, 2019 · 1 share · 2,413 followers View post →
Elibio Rech
@Elibio_Rech · X

There is an urgent need to provide effective anti-HIV microbicides to resource-poor areas worldwide. It is vital to reduce the cost. Enginnering soybean seeds as scalable platform to produce cyanovirin-N, a microbicide against HIV (doi: 10.1111/pbi.12309). Pic: F. Bastos, Embrapa https://t.co/YaYHtDKPnR

Feb 13, 2019 · 2 likes · 1 share · 151 followers View post →
Ed Rybicki
@edrybicki.bsky.social · Bluesky

Engineering soya bean seeds as a scalable platform to produce cyanovirin-N, a non-ARV microbicide ag... | @scoopit

Apr 3, 2015 View post →