PubHawk
Circ Res January 2015 PMID 25599331

Gut microbiota-dependent trimethylamine N-oxide (TMAO) pathway contributes to both development of renal insufficiency and mortality risk in chronic kidney disease.

W H Wilson Tang, Zeneng Wang, David J Kennedy, Yuping Wu, Jennifer A Buffa, Brendan Agatisa-Boyle, Xinmin S Li, Bruce S Levison, Stanley L Hazen

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Mentions

23
Peak: 3 in Jul 2020
across 5 sources since Aug 2019

Extended reach

11,401
potential audience

Total likes

167

Video views

5,744

Mentions per month

Aug 2019 – May 2025

Where it's discussed

  • News8 articles
  • Facebook5 posts
  • Blogs5 articles
  • X / Twitter3 posts
  • YouTube2 videos

AI synopsis

What people are saying

Discussions highlight the significance of TMAO in kidney health, with comments like 'TMAO promotes renal fibrosis' and references to animal studies, reflecting a recognition of the research's importance. The tone and words such as 'strong evidence' and 'bad for your kidneys' convey concern and awareness of potential health consequences, demonstrating balanced engagement and perceived impact.

AgreementModerate agreement

Most discussions support the findings, especially emphasizing TMAO's role in kidney damage and mortality risk.

InterestModerate interest

Posts demonstrate moderate interest, focusing on the implications for health and disease progression.

EngagementModerate engagement

Participants reference specific mechanisms like renal fibrosis and include some mentions of animal studies, showing a reasonable depth of engagement.

ImpactModerate impact

The discussions suggest the research has noteworthy implications for understanding CKD and potential interventions, indicating a moderate impact.

Abstract in brief

  • Elevated TMAO levels are found in patients with chronic kidney disease (CKD) and are associated with an increased risk of mortality over a 5-year period, even after accounting for other risk factors.
  • In CKD patients, higher TMAO levels significantly improve the ability to predict long-term survival outcomes, suggesting its potential as a prognostic biomarker.
  • Animal studies indicate that increasing dietary choline or TMAO can cause kidney damage, including fibrosis and dysfunction, supporting a direct role of TMAO in the progression of renal disease.
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Top posts

Most liked on X and Bluesky
Evan Allen
@EAllen0417 · X

TMAO promotes renal fibrosis (this is bad for your kidneys). The association between TMAO and overall mortality is quite strong, even after controlling for traditional CV risk factors. Animal model shows both TMAO & choline progress renal fibrosis. https://t.co/vNwIewPHpV

Jul 2, 2020 · 3 likes · 1 share · 2,797 followers View post →
Evan Allen
@EAllen0417 · X

@ScepticalDoctor My feed has been full of links. The strongest evidence is the ACM data in my opinion. https://t.co/SW0oIxs4dW https://t.co/vrIaiSvYXZ

Jul 6, 2020 · 1 like · 2,797 followers View post →

All mentions

Evan Allen
@EAllen0417 · X

@ScepticalDoctor My feed has been full of links. The strongest evidence is the ACM data in my opinion. https://t.co/SW0oIxs4dW https://t.co/vrIaiSvYXZ

Jul 6, 2020 · 1 like · 2,797 followers View post →
Go Green
@zzkstk · X

RT @EAllen0417: TMAO promotes renal fibrosis (this is bad for your kidneys). The association between TMAO and overall mortality is quite st…

Jul 2, 2020 · 1 share · 60 followers View post →
Evan Allen
@EAllen0417 · X

TMAO promotes renal fibrosis (this is bad for your kidneys). The association between TMAO and overall mortality is quite strong, even after controlling for traditional CV risk factors. Animal model shows both TMAO & choline progress renal fibrosis. https://t.co/vNwIewPHpV

Jul 2, 2020 · 3 likes · 1 share · 2,797 followers View post →