Circulation March 2015 PMID 25632043

Antiandrogenic therapy with finasteride attenuates cardiac hypertrophy and left ventricular dysfunction.

Carolin Zwadlo, Elisa Schmidtmann, Malgorzata Szaroszyk, Badder Kattih, Natali Froese, Hebke Hinz, Jan Dieter Schmitto, Julian Widder, Sandor Batkai, Heike Bähre, Volkhard Kaever, Thomas Thum, Johann Bauersachs, Joerg Heineke

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Mentions

Peak: 1 in Jul 2023

across 4 sources since Jul 2023

Extended reach

57,483

potential audience

Total likes

686

Video views

27,114

Mentions per month

Jul 2023 – Apr 2025

Where it's discussed

X / Twitter4 posts
Facebook4 posts
YouTube2 videos
News2 articles

AI synopsis

What people are saying

The collective discussions highlight strong agreement with the article's findings, exemplified by comments like 'Finasteride reverses pathological cardiac hypertrophy,' and emphasize its potential as a therapeutic option, with active engagement through references to mechanisms like DHT reduction and clinical relevance, demonstrating both interest and perceived significance.

AgreementStrong agreement

Most discussions clearly support the positive effects of finasteride on heart health, emphasizing its potential benefits and mechanisms.

InterestHigh interest

Posts demonstrate strong curiosity about the therapeutic implications, pharmacology, and broader relevance to health and longevity.

EngagementModerate engagement

Several posts reference specific biological pathways, drug uses, and potential clinical applications, showing thoughtful involvement.

ImpactHigh impact

The discussions suggest that this research could influence future treatment strategies for heart failure, indicating high potential impact.

Abstract in brief

Finasteride, a drug known to inhibit dihydrotestosterone production, was shown to significantly improve heart structure and function in mice with pressure-induced cardiac hypertrophy, reducing fibrosis and preventing heart failure progression.
The study found that enzymes producing dihydrotestosterone are highly active in hypertrophic hearts, leading to increased dihydrotestosterone levels, which contribute to heart damage; finasteride counteracts this by lowering dihydrotestosterone and its harmful effects.
Finasteride's mechanism involves blocking prohypertrophic signaling pathways (like Akt) in heart cells, and it was effective in both male and female mice, suggesting it could be a potential treatment for certain types of heart failure.]

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All mentions

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Finasteride, a medication for prostate issues and hair loss, delays atherosclerosis progression in mice and reduces plasma cholesterol levels in men. It decreases inflammation and influences liver function related to…

Haircafe · Jun 20, 2024 23,421 views

Assessing the Cardiovascular Safety of Testosterone Replacement Therapy

This discussion covers the pros and cons of TRT, including potential risks like atrial fibrillation, kidney injury, and blood pressure changes, based on recent studies. It explores different administration methods and…

Gillett Health · Jul 17, 2023 3,693 views

J O H N

@johnholowach · X

@Winning369369 @HyRillero @bryan_johnson Lowering DHT levels is cardio protective, one reason why women live longer: https://t.co/PUjmGwOqpS

Apr 15, 2025 · 15,311 followers View post →

theonlylolking

@theonlylolking · X

@jjohnpotter It is likely because lower DHT in adulthood. Finasteride lowers DHT and https://t.co/nMNyWzo5mx https://t.co/CNWcLkvGbb https://t.co/vVU70JAFrB https://t.co/oabRAxR6Bb

Oct 3, 2024 · 6 likes · 157 followers View post →

Paul Kiesow

@KiesowPaul · X

Nov 13, 2023 · 4 likes · 1,844 followers View post →

Zetton

@Dr_Zetton · X

@DachsClinic フィナステリドもミノキシジルも、どちらかといえば心臓保護的に働きそうですもんね。https://t.co/TSyIYbYU8O

Sep 7, 2023 · 1 like · 13,057 followers View post →