Nat Med March 2015 PMID 25686106

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease.

Yun-Hee Youm, Kim Y Nguyen, Ryan W Grant, Emily L Goldberg, Monica Bodogai, Dongin Kim, Dominic D'Agostino, Noah Planavsky, Christopher Lupfer, Thirumala D Kanneganti, Seokwon Kang, Tamas L Horvath, Tarek M Fahmy, Peter A Crawford, Arya Biragyn

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Mentions

170

Peak: 13 in Apr 2020

across 6 sources since Jan 2019

Extended reach

588,657

potential audience

Total likes

469

Video views

9,833

Mentions per month

Jan 2019 – Jul 2025

Where it's discussed

X / Twitter60 posts
News44 articles
Facebook42 posts
Blogs15 articles
YouTube6 videos
Reddit3 posts

AI synopsis

What people are saying

The collective discussions express enthusiasm for the research, with posts emphasizing BHB’s specificity in blocking NLRP3 and linking it to anti-inflammatory effects of diets; the tone and detailed references to studies and molecular pathways reflect high interest and perceived significance of this discovery.

AgreementStrong agreement

Most discussions support the findings, emphasizing BHB’s role in inflammation control and highlighting the therapeutic potential of ketogenic diets.

InterestHigh interest

The discussions probe into mechanisms, clinical applications, and broader implications, indicating high curiosity and engagement.

EngagementHigh engagement

Posts reference specific mechanisms like NLRP3 inflammasome inhibition, cite research studies, and discuss therapeutic effects, demonstrating deep engagement.

ImpactHigh impact

Numerous posts highlight the potential for BHB and ketogenic diets to influence inflammatory diseases, suggesting strong perceived impact on health treatments.

Abstract in brief

Hydroxybutyrate (BHB) suppresses the activation of the NLRP3 inflammasome, which is involved in inflammatory diseases, by preventing key processes like K efflux and ASC oligomerization.
BHB's inhibitory effects are specific to NLRP3 and do not affect other inflammasomes or rely on common energy-regulation pathways like AMPK, ROS, or glycolysis, and it does not need to be oxidized in the TCA cycle.
In mouse models and human monocytes, BHB or a ketogenic diet reduces inflammation by decreasing IL-1 and IL-18 production, suggesting potential therapeutic uses for inflammatory conditions linked to NLRP3 activation.

Read the full abstract

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diana flores

@dianaflores37 · X

RT @KetoCounselor: How about this next one stating that evidence suggests anti-inflammatory effects of caloric restriction/keto diets could…

May 28, 2023 · 4 shares · 345 followers View post →

WJW Mental Health Legal Fund

@wjwmhlf · X

RT @KetoCounselor: How about this next one stating that evidence suggests anti-inflammatory effects of caloric restriction/keto diets could…

May 28, 2023 · 4 shares · 1,249 followers View post →

Bobbi Horne

@bob64horne · X

RT @KetoCounselor: How about this next one stating that evidence suggests anti-inflammatory effects of caloric restriction/keto diets could…

May 28, 2023 · 4 shares · 14 followers View post →

Citizen of EU

@wavetossed · X

RT @KetoCounselor: How about this next one stating that evidence suggests anti-inflammatory effects of caloric restriction/keto diets could…

May 27, 2023 · 4 shares · 9,498 followers View post →

Nicole Laurent, LMHC

@KetoCounselor · X

How about this next one stating that evidence suggests anti-inflammatory effects of caloric restriction/keto diets could be due to BHB-inhibited NLRP3 inflammasome. (3/17) https://t.co/JSsTBozCWY

May 27, 2023 · 37 likes · 4 shares · 9,020 followers View post →

Nicole Laurent, LMHC

@KetoCounselor · X

Ketogenic diets show a better reduction of IL-8 than isocaloric diets low in fat over a 12-week period. (15/19) https://t.co/JSsTBozCWY

Feb 26, 2023 · 8 likes · 1 share · 9,020 followers View post →

ياسر ابو دارين

@YasserAbuDarin · X

@Bain_al7naya @eQM5UHccBURdVbg https://t.co/Uq5OuIM2VS https://t.co/GZGC3unmVT https://t.co/znXAiUyDKg https://t.co/Kr52k5wfB7 https://t.co/03MOeNts56 https://t.co/aDlIsFI17j

Dec 19, 2022 · 1 like · 43,057 followers View post →

Dr. Shashank Joshi

@AskDrShashank · X

RT @agingdoc1: The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease (2015) https://t.co/08mF4wu…

Dec 6, 2022 · 3 shares · 32,533 followers View post →

Alexander Dakhovnik

@ADakhovnik · X

RT @agingdoc1: The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease (2015) https://t.co/08mF4wu…

Dec 5, 2022 · 3 shares · 77 followers View post →

Dr. Helen E. Collins

@DrHelenECollin1 · X

RT @agingdoc1: The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease (2015) https://t.co/08mF4wu…

Dec 5, 2022 · 3 shares · 2,198 followers View post →

Agingdoc

@agingdoc1 · X

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease (2015) https://t.co/08mF4wuWG2

Dec 5, 2022 · 12 likes · 3 shares · 41,281 followers View post →

Dr L Boominathan PhD

@DrLBoominathan · X

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease https://t.co/hTNtizUWD7 https://t.co/R0dXUTERSM

Aug 6, 2022 · 1 like · 880 followers View post →

Bruce Burkhalter

@fineartsdad · X

RT @raphaels7: « the anti-inflammatory effects of caloric restriction or ketogenic diets may be linked to BHB-mediated inhibition of the NL…

Dec 5, 2021 · 3 shares · 581 followers View post →

Lulu la nantaise

@Lululanantaise6 · X

RT @raphaels7: « the anti-inflammatory effects of caloric restriction or ketogenic diets may be linked to BHB-mediated inhibition of the NL…

Dec 5, 2021 · 3 shares · 17 followers View post →

Matt James

@MattJames777 · X

RT @raphaels7: « the anti-inflammatory effects of caloric restriction or ketogenic diets may be linked to BHB-mediated inhibition of the NL…

Dec 5, 2021 · 3 shares · 1,970 followers View post →

Raphael Sirtoli

@raphaels7 · X

Dec 5, 2021 · 15 likes · 3 shares · 8,597 followers View post →

Equality 7-2521

@KetoSpeculator · X

@JorjxM @profplum99 @DominicDAgosti2 Here is one: https://t.co/zompQsQYwz

Jul 2, 2021 · 1,869 followers View post →

Henrik Dahlin

@henrikhddahlin · X

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease - PubMed https://t.co/AJ4N9qSEyO

May 17, 2021 · 7 followers View post →

Don Tidwell

@tidwell_don · X

RT @DominicDAgosti2: The ketone metabolite β-hydroxybutyrate also blocks NLRP3 inflammasome. https://t.co/i93DFnOwJb

Apr 10, 2021 · 4 shares · 3,415 followers View post →

David Giordano

@davidjgiordano · X

RT @DominicDAgosti2: The ketone metabolite β-hydroxybutyrate also blocks NLRP3 inflammasome. https://t.co/i93DFnOwJb

Apr 9, 2021 · 4 shares · 10 followers View post →

steenstones

@steenstones · X

RT @DominicDAgosti2: The ketone metabolite β-hydroxybutyrate also blocks NLRP3 inflammasome. https://t.co/i93DFnOwJb

Apr 9, 2021 · 4 shares · 586 followers View post →

Carl Thomas Ball

@carltball122219 · X

RT @DominicDAgosti2: The ketone metabolite β-hydroxybutyrate also blocks NLRP3 inflammasome. https://t.co/i93DFnOwJb

Apr 8, 2021 · 4 shares · 170 followers View post →

eleanorina

@_eleanorina · X

RT @DominicDAgosti2: The ketone metabolite β-hydroxybutyrate also blocks NLRP3 inflammasome. https://t.co/i93DFnOwJb

Apr 8, 2021 · 4 shares · 3,169 followers View post →

Dominic D'Agostino

@DominicDAgosti2 · X

The ketone metabolite β-hydroxybutyrate also blocks NLRP3 inflammasome. https://t.co/i93DFnOwJb

Apr 8, 2021 · 10 likes · 4 shares · 78,007 followers View post →

Nick Norwitz MD PhD

@nicknorwitz · X

@Morgan_Coburn @gwsuperfan @quacklist And bc Quack is allergic to going down the rabit hole here are a few more... https://t.co/oZUPpkk0Ih https://t.co/as6VopnbHx https://t.co/ybaNxnctoP https://t.co/qRGXkhMxue

Feb 5, 2021 · 1 like · 108,743 followers View post →

Nick Norwitz MD PhD

@nicknorwitz · X

@quacklist Nice try skimming. You're not representing the literature. Here are 4 papers to start with https://t.co/oZUPpkk0Ih https://t.co/as6VopnbHx https://t.co/ybaNxnctoP https://t.co/qRGXkhMxue if you want a dozen more I'm happy to supply, if you read them

Feb 5, 2021 · 6 likes · 108,743 followers View post →

Robert'); DROP TABLE Students;

@drop_robert · X

@BrittMezher Boron and keto. Trust me on this one, I've had to deal with reactive and psoriatic arthritis for 20+ years and as long as I behave with my diet I'm symptom free. https://t.co/txwQ2lHFba https://t.co/xN7NOuUMfX

Jan 15, 2021 · 2 likes · 322 followers View post →

Man Manu R

@ManManuR1 · X

@humanageing @agingdoc1 The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease https://t.co/pSBXXRCctW

Oct 30, 2020 · 1 like · 30 followers View post →

KOJI@プライマルコーチ

@kojija · X

【BHBとNLRP3】ケトン体 BHBはマクロファージや好中球のNLRP3活性を阻害し、炎症を抑制 BHB →NLRP3活性⇩ 　→IL-1β⇩、IL-8⇩ 　→Caspase-1⇩ 構造的に似ているAcAc、乳酸、酢酸はこの機能を持たない https://t.co/vAoojZx9lb

Oct 29, 2020 · 3 likes · 1 share · 2,307 followers View post →

Rene Sugar

@renesugar · X

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease https://t.co/AUZMq4i77Y "anti-inflammatory effects of caloric restriction or ketogenic diets may be linked to BHB-mediated inhibition of the NLRP3 inflammasome."

Oct 3, 2020 · 3,952 followers View post →

Penelope Figtree

@PenelopeFigtree · X

@robcennon Ketones inhibit the NLR3P inflammasome https://t.co/u0HyiQ0gde

Sep 13, 2020 · 1 like · 2,244 followers View post →

Nickle101

@Nickle1011 · X

@KenDBerryMD Perhaps through elevated BHB, it may also inhibit the NLRP3 inflammasone pathway https://t.co/r4jWOdkd2D

Aug 24, 2020 · 91 followers View post →

☀️MitoHacker☀️

@mitokondriac · X

@topologic_apple Bloqueo del nlrp3 inflamasoma... La creme... https://t.co/EXL9B2nt5l

Aug 1, 2020 · 1 like · 22,123 followers View post →

Kimpi Huisman

@walkingmaan · X

https://t.co/tmA1Nl4PCo

Jul 10, 2020 · 27 followers View post →

Eve Beavers

@espacetimeCO · X