February 2015 PMID 25721705

Withdrawal Symptoms after Selective Serotonin Reuptake Inhibitor Discontinuation: A Systematic Review.

Giovanni A Fava, Alessia Gatti, Carlotta Belaise, Jenny Guidi, Emanuela Offidani

Mentions

68
Peak: 15 in Mar 2023
across 7 sources since Mar 2015

Extended reach

100,295
potential audience

Total likes

86

Video views

6

Mentions per month

Mar 2015 – Nov 2025

Where it's discussed

  • X / Twitter39 posts
  • News15 articles
  • Instagram7 posts
  • YouTube2 videos
  • TikTok2 posts
  • Reddit2 posts
  • Blogs1 articles

AI synopsis

What people are saying

This collection of discussions demonstrates a strong collective interest and agreement regarding the importance of the systematic review on SSRI withdrawal, with posters referencing specific sections like long-lasting symptoms, delayed effects, and the need for better terminology. The tone ranges from professional critique to advocacy for increased awareness, emphasizing the potential impact of recognizing withdrawal symptoms on clinical practices and patient safety.

AgreementStrong agreement

Most discussions acknowledge the significance of the systematic review by Fava et al., emphasizing the need to recognize withdrawal symptoms and criticize underreporting or trivialization in clinical practice.

InterestHigh interest

Participants show high interest by referencing specific research findings and emphasizing the long-term effects and recognition of withdrawal symptoms that have often been overlooked.

EngagementModerate engagement

Posts reflect active engagement through citations of the paper, debates over clinical responses, and mentions of various health organizations, indicating meaningful discussion rather than superficial mentioning.

ImpactHigh impact

The discussions suggest this publication could influence clinical practice and public awareness about long-term effects of SSRIs, as many argue it highlights critical issues in medication management and patient well-being.

Abstract in brief

  • The systematic review highlights that SSRIs, commonly used antidepressants, can cause withdrawal symptoms when discontinued, with symptoms often appearing within days and lasting several weeks, sometimes with delayed onset or persistence.
  • The prevalence of withdrawal symptoms varies across studies and is frequently underreported due to challenges in identifying these symptoms, which can be mistaken for relapse of the original condition.
  • The authors suggest that the terminology should shift from "discontinuation syndrome" to "withdrawal syndrome" to better emphasize the potential vulnerabilities caused by SSRIs and advise clinicians to be aware of this risk when stopping these medications.]

Top posts

Most liked on X and Bluesky
Brooke Siem — Subscribe to my Substack
@BrookeSiem · X

The first systematic review of antidepressant withdrawal did not even exist until 2015, a full 28 years after Prozac was first released to the public in 1987. https://t.co/0iNjqYKCo9

Mar 3, 2023 · 59 likes · 16 shares · 1,143 followers View post →
Jose Valdecasas
@jose_valdecasas · X

https://t.co/Czw3FNbUkW

Sep 17, 2022 · 8 likes · 3 shares · 2,453 followers View post →
Alyne Duthie
@DuthieAlyne · X

@Louthewarrior @DrHannahBelcher @functionalnurse Fava et al published this paper in 2015 concerning antidepressant withdrawal. "Many variations are possible, including late onset and/or longer persistence of disturbances." https://t.co/WkWLpRfuvY

Oct 11, 2025 · 4 likes · 2 shares · 1,924 followers View post →
Stuart (SSRI taperer)
@FarewellSSRI · X

@DrCarlHindy @cheesyredrocket @jonathanstea @tylerblack32 @psychunseen https://t.co/ZnQHvX2ufC https://t.co/Ypk6SqH2KA

Aug 5, 2025 · 4 likes · 217 followers View post →
Jose Valdecasas
@jose_valdecasas · X

@CALDirector @SEPsiq El Dr.Fava no parece opinar como usted. Saludos. https://t.co/Czw3FNbmvo https://t.co/DpGll6p4A4

Apr 20, 2024 · 2 likes · 3 shares · 2,453 followers View post →
Jose Valdecasas
@jose_valdecasas · X

https://t.co/Czw3FNbUkW

Sep 17, 2022 · 2 likes · 1 share · 2,453 followers View post →

All mentions

MASATOMO
@Masatomoh01 · X

RT @DuthieAlyne: @Louthewarrior @DrHannahBelcher @functionalnurse Fava et al published this paper in 2015 concerning antidepressant withdra…

Oct 13, 2025 · 2 shares · 53 followers View post →
Lou Lou
@Louthewarrior · X

RT @DuthieAlyne: @Louthewarrior @DrHannahBelcher @functionalnurse Fava et al published this paper in 2015 concerning antidepressant withdra…

Oct 11, 2025 · 2 shares · 1,854 followers View post →
Alyne Duthie
@DuthieAlyne · X

@Louthewarrior @DrHannahBelcher @functionalnurse Fava et al published this paper in 2015 concerning antidepressant withdrawal. "Many variations are possible, including late onset and/or longer persistence of disturbances." https://t.co/WkWLpRfuvY

Oct 11, 2025 · 4 likes · 2 shares · 1,924 followers View post →
Stuart (SSRI taperer)
@FarewellSSRI · X

@DrCarlHindy @cheesyredrocket @jonathanstea @tylerblack32 @psychunseen https://t.co/ZnQHvX2ufC https://t.co/Ypk6SqH2KA

Aug 5, 2025 · 4 likes · 217 followers View post →
Thorsten Padberg
@PadbergThorsten · X

@depressionsliga Dazu kommen Entzugssymptome, die nicht dadurch besser werden, dass sie verharmlosend „Absetzsyndrom“ genannt werden. Sie bestehen bei über der Hälfte der Behandelten länger als zwei Wochen, darunter Stimmungsschwankungen, Ängste und vieles mehr. 12/n https://t.co/3memgfPNBU

May 30, 2024 · 2 likes · 862 followers View post →
Silviaenpropiavoz
@SilviaGarcaEst2 · X

RT @jose_valdecasas: @CALDirector @SEPsiq El Dr.Fava no parece opinar como usted. Saludos. https://t.co/Czw3FNbmvo https://t.co/DpGll6p4A4

May 3, 2024 · 3 shares · 552 followers View post →
Desmesura
@Demesura_ · X

RT @jose_valdecasas: @CALDirector @SEPsiq El Dr.Fava no parece opinar como usted. Saludos. https://t.co/Czw3FNbmvo https://t.co/DpGll6p4A4

Apr 20, 2024 · 3 shares · 2,389 followers View post →
postPsiquiatría
@postPsiquiatria · X

RT @jose_valdecasas: @CALDirector @SEPsiq El Dr.Fava no parece opinar como usted. Saludos. https://t.co/Czw3FNbmvo https://t.co/DpGll6p4A4

Apr 20, 2024 · 3 shares · 5,545 followers View post →
Jose Valdecasas
@jose_valdecasas · X

@CALDirector @SEPsiq El Dr.Fava no parece opinar como usted. Saludos. https://t.co/Czw3FNbmvo https://t.co/DpGll6p4A4

Apr 20, 2024 · 2 likes · 3 shares · 2,453 followers View post →
Al Sure
@AlSure5 · X

RT @BrookeSiem: The first systematic review of antidepressant withdrawal did not even exist until 2015, a full 28 years after Prozac was fi…

Mar 6, 2023 · 16 shares · 294 followers View post →
Andy O Barnes
@AndreaB63735256 · X

RT @BrookeSiem: The first systematic review of antidepressant withdrawal did not even exist until 2015, a full 28 years after Prozac was fi…

Mar 5, 2023 · 16 shares · 1,244 followers View post →
PSSD WARRIOR
@PssdWarrior · X

RT @BrookeSiem: The first systematic review of antidepressant withdrawal did not even exist until 2015, a full 28 years after Prozac was fi…

Mar 4, 2023 · 16 shares · 1,434 followers View post →
sic
@kimvie · X

RT @BrookeSiem: The first systematic review of antidepressant withdrawal did not even exist until 2015, a full 28 years after Prozac was fi…

Mar 4, 2023 · 16 shares · 2,526 followers View post →
WJW Mental Health Legal Fund
@wjwmhlf · X

RT @BrookeSiem: The first systematic review of antidepressant withdrawal did not even exist until 2015, a full 28 years after Prozac was fi…

Mar 4, 2023 · 16 shares · 1,303 followers View post →
Jackie Welton DiPillo
@JaxDiP · X

RT @BrookeSiem: The first systematic review of antidepressant withdrawal did not even exist until 2015, a full 28 years after Prozac was fi…

Mar 4, 2023 · 16 shares · 670 followers View post →
La Double Vie
@Onbodyandsoul · X

RT @BrookeSiem: The first systematic review of antidepressant withdrawal did not even exist until 2015, a full 28 years after Prozac was fi…

Mar 4, 2023 · 16 shares · 1,094 followers View post →
Davison
@DavisonVideo · X

RT @BrookeSiem: The first systematic review of antidepressant withdrawal did not even exist until 2015, a full 28 years after Prozac was fi…

Mar 4, 2023 · 16 shares · 6,864 followers View post →
Informed Consent Matters
@stopharmingus · X

RT @BrookeSiem: The first systematic review of antidepressant withdrawal did not even exist until 2015, a full 28 years after Prozac was fi…

Mar 4, 2023 · 16 shares · 1,819 followers View post →
Kim Climer
@RhetoricalGirl0 · X

RT @BrookeSiem: The first systematic review of antidepressant withdrawal did not even exist until 2015, a full 28 years after Prozac was fi…

Mar 4, 2023 · 16 shares · 3,422 followers View post →
recovery&renewal
@recover2renew · X

RT @BrookeSiem: The first systematic review of antidepressant withdrawal did not even exist until 2015, a full 28 years after Prozac was fi…

Mar 4, 2023 · 16 shares · 4,162 followers View post →
Julias Jones
@JsJones994 · X

RT @BrookeSiem: The first systematic review of antidepressant withdrawal did not even exist until 2015, a full 28 years after Prozac was fi…

Mar 3, 2023 · 16 shares · 159 followers View post →
Eddy Lang
@EddyLang1 · X

RT @BrookeSiem: The first systematic review of antidepressant withdrawal did not even exist until 2015, a full 28 years after Prozac was fi…

Mar 3, 2023 · 16 shares · 3,849 followers View post →
cheesyredrocket
@cheesyredrocket · X

RT @BrookeSiem: The first systematic review of antidepressant withdrawal did not even exist until 2015, a full 28 years after Prozac was fi…

Mar 3, 2023 · 16 shares · 3,094 followers View post →
Brooke Siem — Subscribe to my Substack
@BrookeSiem · X

The first systematic review of antidepressant withdrawal did not even exist until 2015, a full 28 years after Prozac was first released to the public in 1987. https://t.co/0iNjqYKCo9

Mar 3, 2023 · 59 likes · 16 shares · 1,143 followers View post →
capsula lunar
@capsulalunar · X

Ustedes acudirían a una psiquiatra que ningunea a la más minima crítica? Es hasta un riesgo Si los medicamentos no tuvieran efectos a largo plazo (que los tienen), para qué los recetan? https://t.co/iJD2qvZW9O https://t.co/7gO9wZrubG https://t.co/qvJBerulAT https://t.co/KPace3VrXg

Nov 3, 2022 · 599 followers View post →
María García Gil
@mariagg26 · X

RT @jose_valdecasas: https://t.co/Czw3FNbUkW

Sep 23, 2022 · 3 shares · 2,798 followers View post →
Manuel_
@Manuel_Com_AV · X

RT @jose_valdecasas: https://t.co/Czw3FNbUkW

Sep 19, 2022 · 3 shares View post →
postPsiquiatría
@postPsiquiatria · X

RT @jose_valdecasas: https://t.co/Czw3FNbUkW

Sep 17, 2022 · 3 shares · 5,545 followers View post →
Jose Valdecasas
@jose_valdecasas · X

https://t.co/Czw3FNbUkW

Sep 17, 2022 · 8 likes · 3 shares · 2,453 followers View post →
Gacela ✳️
@Gacela1980 · X

RT @jose_valdecasas: https://t.co/Czw3FNbUkW

Sep 17, 2022 · 1 share · 3,624 followers View post →
Jose Valdecasas
@jose_valdecasas · X

https://t.co/Czw3FNbUkW

Sep 17, 2022 · 2 likes · 1 share · 2,453 followers View post →
recovery&renewal
@recover2renew · X

RT @DuthieAlyne: @recover2renew You would need to check that your patient wasn't going through withdrawal. Fava et al, 'Withdrawal Symptoms…

Feb 15, 2022 · 1 share · 4,162 followers View post →
Alyne Duthie
@DuthieAlyne · X

@recover2renew You would need to check that your patient wasn't going through withdrawal. Fava et al, 'Withdrawal Symptoms after Selective Serotonin Reuptake Inhibitor Discontinuation: A Systematic Review', Psychother Psychsom 2015; 84:72-98. Under Signs and Symptoms: General > tachycardia.

Feb 7, 2022 · 1 like · 1 share · 1,924 followers View post →
recovery&renewal
@recover2renew · X

RT @recover2renew: per thread. This is happening - to too many people Refs for infographic: 1) AD Withdrawal - Fava et al 2015 https://t.c…

Oct 1, 2021 · 1 share · 4,162 followers View post →
recovery&renewal
@recover2renew · X

per thread. This is happening - to too many people Refs for infographic: 1) AD Withdrawal - Fava et al 2015 https://t.co/Rk87hmxsIg 2) #MUS JCMPH Guidance RCPsych https://t.co/nVbQR5pOdb https://t.co/J7J4P4oXfs

Oct 1, 2021 · 1 share · 4,162 followers View post →
Duncan Double
@DBDouble · X

@BryanMcElroy8 @SameiHuda @DrNandiniC @rcpsych @rcgp @GpTrainees @IrishPsychiatry @RaniBora @markhoro @ProfRobHoward @Chrissox Withdrawal Symptoms after Selective Serotonin Reuptake Inhibitor Discontinuation: A Systematic Review https://t.co/Jf6cBZRy7w

Feb 16, 2021 · 1 like · 3,754 followers View post →
recovery&renewal
@recover2renew · X

RT @recover2renew: Rediscovering this paper … so much important stuff in here: Withdrawal Symptoms after Selective Serotonin Reuptake Inhib…

May 18, 2020 · 1 share · 4,162 followers View post →
recovery&renewal
@recover2renew · X

Rediscovering this paper … so much important stuff in here: Withdrawal Symptoms after Selective Serotonin Reuptake Inhibitor Discontinuation: A Systematic Review https://t.co/OuF8q38CBG

May 18, 2020 · 1 like · 1 share · 4,162 followers View post →
Kindly #deprescribe -- taper psychiatric drugs
@Altostrata · X

@ferguskane Your source being Fava, G.A., Gatti, A., Belaise, C., Guidi, J., Offidani, E., 2015. Withdrawal Symptoms after Selective Serotonin Reuptake Inhibitor Discontinuation: A Systematic Review. PPS 84, 72–81. https://t.co/ZAWn4DViSO -- correct? https://t.co/2zafyRQ8iw https://t.co/DuG2Td1I1P

Jun 6, 2019 · 6,578 followers View post →
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