J Am Coll Cardiol April 2015 PMID 25835438

Impact of statins on serial coronary calcification during atheroma progression and regression.

Rishi Puri, Stephen J Nicholls, Mingyuan Shao, Yu Kataoka, Kiyoko Uno, Samir R Kapadia, E Murat Tuzcu, Steven E Nissen

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Mentions

55
Peak: 6 in Dec 2020
across 4 sources since Dec 2020

Extended reach

527,144
potential audience

Total likes

5,524

Video views

187,154

Mentions per month

Dec 2020 – Oct 2025

Where it's discussed

  • X / Twitter40 posts
  • Facebook8 posts
  • News4 articles
  • YouTube3 videos

AI synopsis

What people are saying

Several discussions examine whether calcification caused by statins is detrimental or beneficial, with posts using words like 'stabilize' and 'progress' to explore this paradox. The tone varies from cautious skepticism to scientific curiosity, emphasizing an in-depth engagement with the article's implications on cardiovascular risk management.

AgreementModerate agreement

Most discussions acknowledge that statins are linked to increased calcification, with some highlighting that this may actually be part of their stabilizing effect on plaques, indicating a moderate consensus.

InterestHigh interest

Discussions show significant curiosity, with many posts mentioning complex concepts like plaque stabilization, calcification, and the overall impact of statins, reflecting high engagement interest.

EngagementHigh engagement

Posts often reference specific mechanisms, citations of scientific journals, and clinical implications, showing deep analysis and thoughtful engagement.

ImpactHigh impact

Given the focus on how calcification might indicate plaque stabilization and influence treatment understanding, users perceive the study as having a notable impact on clinical strategies and perceptions of statin therapy.

Abstract in brief

  • This study analyzed how different levels of statin therapy impact coronary artery plaque volume and calcification, finding that high-intensity statins can reduce plaque size but may increase calcification, which is important for plaque stability.
  • All patient groups, regardless of statin use, showed an increase in calcium indices, suggesting statins promote coronary calcification in vivo, consistent with preclinical suggestions of procalcific effects.
  • The study found no link between changes in calcification and levels of lipoproteins or inflammatory markers, indicating that calcification might be a separate process influenced by statins, contributing to plaque stabilization and potentially lowering cardiovascular risk.

Top posts

Most liked on X and Bluesky
Gil Carvalho MD PhD
@NutritionMadeS3 · X

Low Carb diets & Heart Health ▶️heart-healthy, low carb sources of fat and protein ▶️starchy vs non-starchy veg ▶️a low carb cardiologist´s take on oil, butter, salt Low carb =/= high cholesterol/high ApoB !!!!!! part II with @ethanjweiss https://t.co/HrhgyZ5x9v

Nov 7, 2022 · 29 likes · 3 shares · 27,940 followers View post →
Thomas Dayspring
@Drlipid · X

@Kevin4Liberty Acceleration of calcification is a desirable effect that shows the statins are working - the plaque iso not only stabilizing (calcifying) but also regressing (see graphics). Stop wasting $$ on repeat CAC. Please read https://t.co/0gtb3ZKftO https://t.co/j6ybzLj4sN

Jun 26, 2023 · 12 likes · 1 share · 42,127 followers View post →
Sean Stewart
@umdpharmd · X

A3: Statins actually have been demonstrated to increase CAC by promoting coronary atheroma calcification. However, this may be how statins stabilize plaques. https://t.co/m5rdvBb0l2. #NLATwitterChat #NLACAC https://t.co/bAOiVtHgWf

Dec 3, 2020 · 9 likes · 3 shares · 352 followers View post →
Agingdoc
@agingdoc1 · X

Impact of Statins on Coronary Calcification During Atheroma Progression & Regression A reminder to our pts it may be the MOA for stabilization ⁦@JACCJournals⁩ ⁦@nationallipid⁩ ⁦@jlipidres⁩ ⁦@ExpertLipid⁩ ⁦⁦@atherosociety⁩ https://t.co/p1ivGytzBa

Dec 5, 2020 · 4 likes · 42,362 followers View post →
Dr. Ozan Ünlü
@DrOzanUnlu · X

Referanslar: https://t.co/bCwaPVvI4K https://t.co/2CayD1CE3F https://t.co/TOUl8PAobu https://t.co/0QloGwsRiY https://t.co/KYfLpt3tOS https://t.co/Q39TwUAEof https://t.co/7EuElwQxFy https://t.co/6ku6YeNyLc https://t.co/xuFPwg8ueG https://t.co/ekOjIkTf0S

May 6, 2024 · 4 likes · 36,523 followers View post →
Gil Carvalho MD PhD
@NutritionMadeS3 · X

@vardaanbhat low carb and healthy lipids are not mutually exclusive. that notion is an internet construct https://t.co/HrhgyZ4ZjX

Mar 4, 2023 · 4 likes · 27,940 followers View post →

All mentions

david wolstenholme
@davidwo79952625 · X

Statins Work... But You MUST Know THIS! https://t.co/SLcHpLJFkE via @YouTube

Oct 18, 2025 · 442 followers View post →
Hoggo
@HoraceOflaherty · X

Statins Problematical https://t.co/KhZmJh0EVR

Oct 4, 2025 · 2,864 followers View post →
mi2bobswrth
@mi2bobs · X

Statins Work... But You MUST Know THIS! Lifestyle i.e Exercise & diet is most important Dr. Ford Brewer https://t.co/2LMc06Q9Dl

Oct 2, 2025 · 161 followers View post →
Andreas Helke
@AndreasHelke · X

Statins Work... But You MUST Know THIS! https://t.co/sr9CZyCt50 via @YouTube

Sep 26, 2025 · 106 followers View post →
Talisker Skye
@taliskeronskye · X

@thewalkerseven @goddeketal Like with most things, the answer depends, and lies somewhere between the extremes. https://t.co/yTVF9xpYMn

Sep 23, 2025 · 2 likes · 365 followers View post →
Sunil Chankersingh
@renanzsignals · X

How I Use Statins to Unclog Arteries https://t.co/UARmOUj7mZ via @YouTube

Sep 14, 2025 · 237 followers View post →
matsukura masaki
@_M31_ · X

RT @keisuke4713: アテローム進行・冠状動脈石灰化 スタチン影響https://t.co/TMF6YlzrLH プラーク退行効果と無関係にスタチンは冠状動脈アテローム石灰化⬆️ 無スタチン 自然プラーク進行⇨脂質プール内微小石灰化と相まって脂質プール拡大 高強度…

Aug 4, 2024 · 5 shares · 2,975 followers View post →
Rusty Sashwaite
@RustySashwaite · X

@LoCvet @Marion436842126 https://t.co/riEx8ceFIS

Aug 3, 2024 · 2 likes · 487 followers View post →
Rusty Sashwaite
@RustySashwaite · X

@Marion436842126 https://t.co/riEx8ceFIS

Aug 3, 2024 · 487 followers View post →
限界漂流
@NetSurfNote · X

RT @keisuke4713: アテローム進行・冠状動脈石灰化 スタチン影響https://t.co/TMF6YlzrLH プラーク退行効果と無関係にスタチンは冠状動脈アテローム石灰化⬆️ 無スタチン 自然プラーク進行⇨脂質プール内微小石灰化と相まって脂質プール拡大 高強度…

Jul 6, 2024 · 5 shares · 863 followers View post →
Dr. Ozan Ünlü
@DrOzanUnlu · X

Referanslar: https://t.co/bCwaPVvI4K https://t.co/2CayD1CE3F https://t.co/TOUl8PAobu https://t.co/0QloGwsRiY https://t.co/KYfLpt3tOS https://t.co/Q39TwUAEof https://t.co/7EuElwQxFy https://t.co/6ku6YeNyLc https://t.co/xuFPwg8ueG https://t.co/ekOjIkTf0S

May 6, 2024 · 4 likes · 36,523 followers View post →
Gil Carvalho MD PhD
@NutritionMadeS3 · X

@ozlfc1982 hi, we have one exactly like that https://t.co/HrhgyZ4ZjX

Oct 22, 2023 · 2 likes · 27,940 followers View post →
James
@_jeemus · X

@Drlipid Any help on these please, difficult to make the right decision Statin increases plaque progression: https://t.co/sZc10iKe6D Statin increases plaque progression: https://t.co/CaTnuy9ZB6 Statin increases CAC: https://t.co/oKw1XG1d37 Statin increases CAC: https://t.co/8XOl4VQW34

Aug 18, 2023 · 127 followers View post →
James
@_jeemus · X

@Paddy_Barrett I'm facing this choice,opinion on these would help Statin increases vascular calcification: https://t.co/sZc10iKe6D Statin increases CAC score&plaque progression: https://t.co/CaTnuy9ZB6 Statin increases CAC: https://t.co/oKw1XG1d37 Statin increases CAC: https://t.co/8XOl4VQW34

Aug 18, 2023 · 3 likes · 127 followers View post →
Batman-Echo
@echo_batman · X

@abdelhamed012 @iamritu @JACCJournals @BudoffMd @almallahmo @lesleejshaw @ToddVillinesMD @Heart_SCCT @AChoiHeart @ErinMichos @DrMarthaGulati @purviparwani Statins can based on observational data: https://t.co/AEyUYMm7Rj https://t.co/snkf90O5dC https://t.co/3veDld8Y6c GLP1 RA: don’t know …

Jul 22, 2023 · 2 likes · 1,328 followers View post →
TedRenwick
@RenwickTed · X

RT @Drlipid: @Kevin4Liberty Acceleration of calcification is a desirable effect that shows the statins are working - the plaque iso not onl…

Jun 27, 2023 · 1 share · 16 followers View post →
Thomas Dayspring
@Drlipid · X

@Kevin4Liberty Acceleration of calcification is a desirable effect that shows the statins are working - the plaque iso not only stabilizing (calcifying) but also regressing (see graphics). Stop wasting $$ on repeat CAC. Please read https://t.co/0gtb3ZKftO https://t.co/j6ybzLj4sN

Jun 26, 2023 · 12 likes · 1 share · 42,127 followers View post →
Red-pilled Rebel
@doctorvasan · X

@LDLSkeptic @robertlufkinmd @DrPaulMason @BenBikmanPhD @ethanjweiss Your paper has cherry picked studies to suit your agenda, conveniently ignore wealth of evidence and hordes of studies that have shown linear relationships between Apo-B (and LDL) and ASCVD. https://t.co/0tvuN1ctPH

Jun 6, 2023 · 1,486 followers View post →
Ippei, 大工見習い in NZ
@IT2013000440 · X

ケトダイエット(低炭水化物で高脂質で疑問は どんな脂肪をとればいいということ。 心臓専門医の彼は、 水銀蓄積少ない魚とたくさんのオリーブオイル、 適度に肉 クッキングにはアヴォカドオイル。 飽和脂肪酸、バターなど、は心臓の健康のためにさける。 https://t.co/nCemGC7wuN via @YouTube

Apr 8, 2023 · 3 likes · 796 followers View post →
Ethan Alexander, M.D.
@JayhawkLipidDoc · X

@TheNutrivore @BioLayne CAC is always a one step extrapolation. I’m not worrried about the calcified plaque. I’m worried about the soft vulnerable plaque that is implied due to the discovery of calcified plaque. Statins impact calcification. https://t.co/9FyXucX0cV

Mar 9, 2023 · 1 like · 344 followers View post →
Gil Carvalho MD PhD
@NutritionMadeS3 · X

@arvindsrinivasa @Drlipid @hjluks how much have you optimized diet? https://t.co/HrhgyZ4ZjX if you prefer low carb, here are some tips to optimize ApoB on a low carb diet

Mar 8, 2023 · 2 likes · 27,940 followers View post →
Gil Carvalho MD PhD
@NutritionMadeS3 · X

@vardaanbhat low carb and healthy lipids are not mutually exclusive. that notion is an internet construct https://t.co/HrhgyZ4ZjX

Mar 4, 2023 · 4 likes · 27,940 followers View post →
at sushi
@JOf1MMMIos9r0y0 · X

RT @keisuke4713: アテローム進行・冠状動脈石灰化 スタチン影響https://t.co/TMF6YlzrLH プラーク退行効果と無関係にスタチンは冠状動脈アテローム石灰化⬆️ 無スタチン 自然プラーク進行⇨脂質プール内微小石灰化と相まって脂質プール拡大 高強度…

Feb 7, 2023 · 5 shares · 4,197 followers View post →
Harmless Frog
@FrogHarmless · X

@Nutradvance @ScepticalDoctor @ethanjweiss Per him, chiefly vegetables and fish. He describes it here: https://t.co/qHpNr8eH8e

Nov 27, 2022 · 1 like · 503 followers View post →
Jan Vyjidak
@janvyjidak · X

RT @NutritionMadeS3: Low Carb diets & Heart Health ▶️heart-healthy, low carb sources of fat and protein ▶️starchy vs non-starchy veg ▶️a l…

Nov 8, 2022 · 3 shares · 4,149 followers View post →
Craig
@JeffersonCraigg · X

RT @NutritionMadeS3: Low Carb diets & Heart Health ▶️heart-healthy, low carb sources of fat and protein ▶️starchy vs non-starchy veg ▶️a l…

Nov 7, 2022 · 3 shares · 825 followers View post →
Bhopender Thakur
@TheBhupiThakur · X

RT @NutritionMadeS3: Low Carb diets & Heart Health ▶️heart-healthy, low carb sources of fat and protein ▶️starchy vs non-starchy veg ▶️a l…

Nov 7, 2022 · 3 shares · 1,369 followers View post →
Gil Carvalho MD PhD
@NutritionMadeS3 · X

Low Carb diets & Heart Health ▶️heart-healthy, low carb sources of fat and protein ▶️starchy vs non-starchy veg ▶️a low carb cardiologist´s take on oil, butter, salt Low carb =/= high cholesterol/high ApoB !!!!!! part II with @ethanjweiss https://t.co/HrhgyZ5x9v

Nov 7, 2022 · 29 likes · 3 shares · 27,940 followers View post →
Brian Engel
@realbrianengel · X

@HollyLarsson1 @MattBMartin @drpablocorral @NutritionMadeS3 I think there are few more out there... It's been awhile since my nerd safari on this topic. https://t.co/THY9I3tY2B

Aug 14, 2022 · 1 like · 18 followers View post →
たら
@pituitarypars · X

RT @keisuke4713: アテローム進行・冠状動脈石灰化 スタチン影響https://t.co/TMF6YlzrLH プラーク退行効果と無関係にスタチンは冠状動脈アテローム石灰化⬆️ 無スタチン 自然プラーク進行⇨脂質プール内微小石灰化と相まって脂質プール拡大 高強度…

Apr 28, 2022 · 5 shares · 133 followers View post →
tune
@keisuke4713 · X

アテローム進行・冠状動脈石灰化 スタチン影響https://t.co/TMF6YlzrLH プラーク退行効果と無関係にスタチンは冠状動脈アテローム石灰化⬆️ 無スタチン 自然プラーク進行⇨脂質プール内微小石灰化と相まって脂質プール拡大 高強度スタチン⇨プラーク退行:脱脂・血管平滑筋細胞石灰化、プラーク安定性⬆️ https://t.co/1y9izO0Mx0

Apr 27, 2022 · 4 likes · 5 shares · 3,742 followers View post →
Nathan Owens
@NathanEqualsOne · X

@MacroEight @Andrew__Lima @The_Nutrivore There's a lot of published literature on it: https://t.co/KnR2Agkzhh, https://t.co/qfQQzSmgn7 - this is a well accepted thing in cardiology, afaik.

Nov 9, 2021 · 2,108 followers View post →
Thomas Dayspring
@Drlipid · X

@jcspratt Not in a tweet - the info you seek can be found here https://t.co/0gtb3ZKftO

Oct 8, 2021 · 1 like · 42,127 followers View post →
Nick Eggleton
@NickEggleton · X

@DoctorTro 2/2 These make me sceptical. https://t.co/EDOaHZwmZf https://t.co/JVC4GwsCBG https://t.co/vGNQauhAe9

Jul 15, 2021 · 2,221 followers View post →
For health-promoting environments
@SilkeLeFay · X

#CVD #dementia #NCDs #NOTCH1 #health . Independent of their plaque-regressive effects, statins promote coronary atheroma calcification. https://t.co/oFRXmqTBrp Statin therapy was associated with greater progression of coronary artery calcification (CAC) https://t.co/e1tKv5q5AP . https://t.co/jUXWhHQAk4

Dec 10, 2020 · 4,587 followers View post →
Agingdoc
@agingdoc1 · X

Impact of Statins on Coronary Calcification During Atheroma Progression & Regression A reminder to our pts it may be the MOA for stabilization ⁦@JACCJournals⁩ ⁦@nationallipid⁩ ⁦@jlipidres⁩ ⁦@ExpertLipid⁩ ⁦⁦@atherosociety⁩ https://t.co/p1ivGytzBa

Dec 5, 2020 · 4 likes · 42,362 followers View post →
Dr. James Underberg
@lipiddoc · X

RT @umdpharmd: A3: Statins actually have been demonstrated to increase CAC by promoting coronary atheroma calcification. However, this may…

Dec 3, 2020 · 3 shares · 13,812 followers View post →
National Lipid Association
@nationallipid · X

RT @umdpharmd: A3: Statins actually have been demonstrated to increase CAC by promoting coronary atheroma calcification. However, this may…

Dec 3, 2020 · 3 shares · 13,417 followers View post →
0x Numbers
@CaseyElkinsDNP · X

RT @umdpharmd: A3: Statins actually have been demonstrated to increase CAC by promoting coronary atheroma calcification. However, this may…

Dec 3, 2020 · 3 shares · 347 followers View post →
Sean Stewart
@umdpharmd · X

A3: Statins actually have been demonstrated to increase CAC by promoting coronary atheroma calcification. However, this may be how statins stabilize plaques. https://t.co/m5rdvBb0l2. #NLATwitterChat #NLACAC https://t.co/bAOiVtHgWf

Dec 3, 2020 · 9 likes · 3 shares · 352 followers View post →