PubHawk
J Am Chem Soc May 2015 PMID 25870881

Toward Efficient Enzymes for the Generation of Universal Blood through Structure-Guided Directed Evolution.

David H Kwan, Iren Constantinescu, Rafi Chapanian, Melanie A Higgins, Miriam P Kötzler, Eric Samain, Alisdair B Boraston, Jayachandran N Kizhakkedathu, Stephen G Withers

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Mentions

117
Peak: 22 in Aug 2020
across 5 sources since Aug 2018

Extended reach

698,011
potential audience

Total likes

16,268

Video views

520,950

Mentions per month

Aug 2018 – Sep 2025

Where it's discussed

  • Facebook41 posts
  • X / Twitter38 posts
  • News27 articles
  • Blogs9 articles
  • YouTube2 videos

AI synopsis

What people are saying

The overall tone reflects curiosity, particularly from posts questioning whether blood types can change and sharing videos about the research, which indicates interest but not strong agreement or detailed engagement. Examples include comments like 'Could Your Blood Type Ever Change?' with mentions of videos and discussions, highlighting a general fascination and a desire for more information.

AgreementNeither agree nor disagree

Most discussions show curiosity rather than strong agreement or disagreement with the research implications.

InterestModerate interest

Many social discussions indicate moderate interest, especially related to the possibility of blood type changes and enzyme advancements.

EngagementModerate engagement

Participants are engaging with the topic by sharing videos and asking questions, but often in a superficial manner without deep technical analysis.

ImpactNeutral impact

The conversations suggest general curiosity but lack widespread evidence of the research's transformative impact at this stage.

Abstract in brief

  • This text discusses how scientists are working on creating more effective enzymes to convert regular blood into universal donor blood (type O) by removing specific antigens (A and B) from red blood cells, which currently is a slow process.
  • Using a family of enzymes from Streptococcus pneumoniae, researchers have used a technique called structure-guided directed evolution to develop enzyme variants that are much better at breaking down the blood group antigens that are usually resistant to removal.
  • The improved enzymes can more completely strip these antigens from red blood cells, potentially making blood transfusions safer and more universally compatible by engineering enzymes that can produce "antigennull" blood.]
Read the full abstract

Top posts

Most liked on X and Bluesky
SciShow
@SciShow · X

Is it possible for your blood type to change? Well, yes… but it wouldn’t take you by surprise. https://t.co/eUWWmupnzv https://t.co/PFDcRI58Gg

Aug 1, 2020 · 37 likes · 7 shares · 115,089 followers View post →
tune
@keisuke4713 · X

Could Your Blood Type Ever Change? https://t.co/XhkZiOeQM8 造血幹細胞移植 https://t.co/TDAMn3tMkw 移植後,

Nov 5, 2024 · 36 likes · 12 shares · 3,739 followers View post →
OmniPuro
@OmniPuro · X

#ぷろHealth #ぷろEnglish ◆#今日のリスニング :2020/08/02 Could Your Blood Type Ever Change? - YouTube https://t.co/RSG6gPpgq0

Aug 2, 2020 · 1 like · 12,836 followers View post →
Xavier Duran
@xduran_e · X

@therfer @NatureMicrobiol Veig que un equip canadenc va publicar un treball semblant amb un altre bacteri el 2015, però no he trobat més resultats publicats https://t.co/mK3ZHgUHHS

Apr 30, 2024 · 1 like · 3,044 followers View post →
Ahmad Younis
@AhmadYounis15 · X

Could Your Blood Type Ever Change? https://t.co/wf6ZAEWoLe via @YouTube

Aug 1, 2020 · 1 like · 1,015 followers View post →
Folmer Fredslund @folfdk@helvede.net
@folfDK · X

@GntlmnScientist Sounds very similar to what Steve Withers is working on for a while https://t.co/0qL66ROgLp

Sep 12, 2020 · 1 like · 370 followers View post →

All mentions

ايمان || エマン
@em_200k · X

RT @iBB_2020: أنجاز.. باحثون صنعو انزيم يعمل على تكسير الأنتجين المكون للفصيلة A و B بحيث يتحول الدم الي فصيلة O وكذلك Null-Antigen http://…

Sep 5, 2025 · 17 shares · 163 followers View post →
tune
@keisuke4713 · X

https://t.co/lHClbSLKNW https://t.co/EOPSCjqStH A型B型

Nov 7, 2024 · 3,742 followers View post →
ワクチン問題の本質を問う
@Astrology1962 · X

RT @keisuke4713: Could Your Blood Type Ever Change? https://t.co/XhkZiOeQM8 造血幹細胞移植 https://t.co/TDAMn3tMkw 移植後,

Nov 6, 2024 · 12 shares · 665 followers View post →
HSP、真実はいずこ？
@HSPFireLife · X

RT @keisuke4713: Could Your Blood Type Ever Change? https://t.co/XhkZiOeQM8 造血幹細胞移植 https://t.co/TDAMn3tMkw 移植後,

Nov 6, 2024 · 12 shares · 433 followers View post →
Tabatha
@araran100 · X

RT @keisuke4713: Could Your Blood Type Ever Change? https://t.co/XhkZiOeQM8 造血幹細胞移植 https://t.co/TDAMn3tMkw 移植後,

Nov 5, 2024 · 12 shares · 17,495 followers View post →
守田朋生
@oBmvUtvfmbgG9zT · X

RT @keisuke4713: Could Your Blood Type Ever Change? https://t.co/XhkZiOeQM8 造血幹細胞移植 https://t.co/TDAMn3tMkw 移植後,

Nov 5, 2024 · 12 shares · 45 followers View post →
win2enfant
@win2enfant · X

RT @keisuke4713: Could Your Blood Type Ever Change? https://t.co/XhkZiOeQM8 造血幹細胞移植 https://t.co/TDAMn3tMkw 移植後,

Nov 5, 2024 · 12 shares · 307 followers View post →
Azazel
@j9kEPwFTT258587 · X

RT @keisuke4713: Could Your Blood Type Ever Change? https://t.co/XhkZiOeQM8 造血幹細胞移植 https://t.co/TDAMn3tMkw 移植後,

Nov 5, 2024 · 12 shares · 657 followers View post →
hannna
@hannahumming · X

RT @keisuke4713: Could Your Blood Type Ever Change? https://t.co/XhkZiOeQM8 造血幹細胞移植 https://t.co/TDAMn3tMkw 移植後,

Nov 5, 2024 · 12 shares · 2,687 followers View post →
Liberty
@Libertygranny · X

RT @keisuke4713: Could Your Blood Type Ever Change? https://t.co/XhkZiOeQM8 造血幹細胞移植 https://t.co/TDAMn3tMkw 移植後,

Nov 5, 2024 · 12 shares · 1,504 followers View post →
つとむ
@tsutomuinfinity · X

RT @keisuke4713: Could Your Blood Type Ever Change? https://t.co/XhkZiOeQM8 造血幹細胞移植 https://t.co/TDAMn3tMkw 移植後,

Nov 5, 2024 · 12 shares · 188 followers View post →
hanano iro wa
@wsl_j0 · X

RT @keisuke4713: Could Your Blood Type Ever Change? https://t.co/XhkZiOeQM8 造血幹細胞移植 https://t.co/TDAMn3tMkw 移植後,

Nov 5, 2024 · 12 shares · 349 followers View post →
猫まんま17歳用
@14nHQQSduI9QmOY · X

RT @keisuke4713: Could Your Blood Type Ever Change? https://t.co/XhkZiOeQM8 造血幹細胞移植 https://t.co/TDAMn3tMkw 移植後,

Nov 5, 2024 · 12 shares · 486 followers View post →
tune
@keisuke4713 · X

Could Your Blood Type Ever Change? https://t.co/XhkZiOeQM8 造血幹細胞移植 https://t.co/TDAMn3tMkw 移植後,

Nov 5, 2024 · 36 likes · 12 shares · 3,739 followers View post →
Danny Flinker
@FlinkerDanny · X

https://t.co/kZ0dfqNrj4

Jul 31, 2024 · 145 followers View post →
Xavier Duran
@xduran_e · X

@therfer @NatureMicrobiol Veig que un equip canadenc va publicar un treball semblant amb un altre bacteri el 2015, però no he trobat més resultats publicats https://t.co/mK3ZHgUHHS

Apr 30, 2024 · 1 like · 3,044 followers View post →
Folmer Fredslund @folfdk@helvede.net
@folfDK · X

@GntlmnScientist Sounds very similar to what Steve Withers is working on for a while https://t.co/0qL66ROgLp

Sep 12, 2020 · 1 like · 370 followers View post →
άραχθος
@_arachthos · X

https://t.co/XWtxmXb1vS

Aug 4, 2020 · 85 followers View post →
❤️KHO
@Tayyaba_94 · X

RT @CharlesIkenna23: Could Your Blood Type Ever Change? https://t.co/eeBb9sWxo8 via @YouTube

Aug 3, 2020 · 1 share · 2,602 followers View post →
Cecile Braconnier
@braco001 · X

Could Your Blood Type Ever Change? https://t.co/Zn6lFsShIm via @YouTube

Aug 3, 2020 · 737 followers View post →
Charles Ikenna
@CharlesIkenna23 · X

Could Your Blood Type Ever Change? https://t.co/eeBb9sWxo8 via @YouTube

Aug 3, 2020 · 1 share · 3,225 followers View post →
Antwann Pleasants
@AntwannPleasant · X

I'm watching "Could Your Blood Type Ever Change?". Watch Now: https://t.co/PwaZagna7S

Aug 2, 2020 · 3 followers View post →
タラー
@4bG92ZU5hbQ6 · X

RT @SciShow: Is it possible for your blood type to change? Well, yes… but it wouldn’t take you by surprise. https://t.co/eUWWmupnzv https:…

Aug 2, 2020 · 7 shares · 99 followers View post →
Regi Bonner
@regibonn · X

https://t.co/TEHDsppfzm

Aug 2, 2020 · 332 followers View post →
Luca
@SorrisoCattivo · X

https://t.co/w7BfmEk1ze

Aug 2, 2020 · 141 followers View post →
Ned
@nedX07 · X

RT @SciShow: Is it possible for your blood type to change? Well, yes… but it wouldn’t take you by surprise. https://t.co/eUWWmupnzv https:…

Aug 2, 2020 · 7 shares · 47 followers View post →
OmniPuro
@OmniPuro · X

#ぷろHealth #ぷろEnglish ◆#今日のリスニング :2020/08/02 Could Your Blood Type Ever Change? - YouTube https://t.co/RSG6gPpgq0

Aug 2, 2020 · 1 like · 12,836 followers View post →
Jemond
@Jemonji · X

RT @SciShow: Is it possible for your blood type to change? Well, yes… but it wouldn’t take you by surprise. https://t.co/eUWWmupnzv https:…

Aug 2, 2020 · 7 shares · 32 followers View post →
Tariq Al Habtoor
@tariqalhabtoor · X

Can your blood type change https://t.co/gPtpZuSCOY

Aug 2, 2020 · 301 followers View post →
@Romaq@qoto.org
@Romaq · X

RT @SciShow: Is it possible for your blood type to change? Well, yes… but it wouldn’t take you by surprise. https://t.co/eUWWmupnzv https:…

Aug 1, 2020 · 7 shares · 92 followers View post →
e-csce
@e_csce · X

Could Your Blood Type Ever Change? @ https://t.co/udNuVjuEo2 https://t.co/EQEzdpzRfw

Aug 1, 2020 · 117 followers View post →
Ordo Fraterna Fibonacci
@OrdoFibonacci · X

Could Your Blood Type Ever Change? https://t.co/tGjlqoBG99 via @YouTube

Aug 1, 2020 · 2,568 followers View post →
William Wallace
@bill14051 · X

RT @SciShow: Is it possible for your blood type to change? Well, yes… but it wouldn’t take you by surprise. https://t.co/eUWWmupnzv https:…

Aug 1, 2020 · 7 shares · 368 followers View post →
Andrea J.
@esgaril · X

RT @SciShow: Is it possible for your blood type to change? Well, yes… but it wouldn’t take you by surprise. https://t.co/eUWWmupnzv https:…

Aug 1, 2020 · 7 shares · 128 followers View post →
Ahmad Younis
@AhmadYounis15 · X

Could Your Blood Type Ever Change? https://t.co/wf6ZAEWoLe via @YouTube

Aug 1, 2020 · 1 like · 1,015 followers View post →
SciShow
@SciShow · X

Is it possible for your blood type to change? Well, yes… but it wouldn’t take you by surprise. https://t.co/eUWWmupnzv https://t.co/PFDcRI58Gg

Aug 1, 2020 · 37 likes · 7 shares · 115,089 followers View post →
Johannes Lüke
@JohannesSLueke · X

New video by SciShow: Could Your Blood Type Ever Change? https://t.co/W3hA47b3nI

Aug 1, 2020 · 83 followers View post →
Kitty
@kittybravofan · X

Could Your Blood Type Ever Change? https://t.co/LPWfB8QYXn via @YouTube

Aug 1, 2020 · 719 followers View post →