February 2016 PMID 25877232

Human skin penetration of hyaluronic acid of different molecular weights as probed by Raman spectroscopy.

M Essendoubi, C Gobinet, R Reynaud, J F Angiboust, M Manfait, O Piot

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Mentions

Peak: 9 in Feb 2022

across 7 sources since May 2017

Extended reach

682,945

potential audience

Total likes

12,075

Video views

527,027

Mentions per month

May 2017 – Mar 2025

Where it's discussed

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AI synopsis

What people are saying

Overall, the discussions reveal a high level of interest and general agreement with the article's conclusions, exemplified by comments emphasizing the relevance of molecular weight in skin penetration, such as 'tout dépend de son poids moléculaire.' The tone varies from caution to appreciation, with some users urging others to understand the topic better before commenting, indicating engagement with the scientific content and its implications.

AgreementModerate agreement

Most discussions align with the article's findings that molecular weight influences skin penetration, showing general support for the published conclusions.

InterestHigh interest

The discussions demonstrate high curiosity, especially with posts referencing the specifics of molecular weight and penetration depth.

EngagementModerate engagement

While some comments briefly mention the technique used, like Raman spectroscopy, most engage with the topic's significance, indicating a moderate depth of discussion.

ImpactModerate impact

Posts highlight the importance of understanding how different weights of hyaluronic acid can affect skin care and medical applications, suggesting a moderate recognition of its importance.

Abstract in brief

The study uses Raman spectroscopy to analyze how hyaluronic acid (HA) of different molecular weights penetrates human skin, overcoming limitations of traditional methods like Franz diffusion cells.
Results show that low molecular weight HA (around 20-300 kDa) can pass through the skin's outer layer (stratum corneum), whereas high molecular weight HA (1000-1400 kDa) remains impermeable.
Raman microimaging is highlighted as a non-destructive, precise technique that can dynamically track the distribution and permeation of active molecules within skin layers.]

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All mentions

Choosing the Best Serum: Vichy, La Roche Posay, The Ordinary Comparison

This video compares popular serums from Vichy, La Roche Posay, and The Ordinary, focusing on ingredients like Vitamin C, Niacinamide, and Hyaluronic Acid to help you select the most effective option for skin…

Dermisphere Dra. Leire Barrutia · Jun 16, 2022 443,109 views

Effectiveness of Hyaluronic Acid in Skin Care: Low vs High Molecular Weight

Hyaluronsure in cosmetics is popular, but does it actually benefit the skin? This video explores how low and high molecular weight hyaluronic acid penetrate the skin using Raman spectroscopy, providing insights into…

DoktorJulie · Aug 16, 2020 83,918 views

Phoenix

@burningphoenix.bsky.social · Bluesky

But... pubmed.ncbi.nlm.nih.gov/25877232/

Jun 11, 2024 · 2 likes · 1 share View post →

Mimi Pinson

@mmepinceaux · X

@The_Economiss Ca depend du poids moléculaire https://t.co/lmFv7vcoje

Jan 20, 2023 · 3 likes · 177 followers View post →

celineemrn

@celineemrn · X

Jan 19, 2023 · 9 likes · 104 followers View post →