FASEB J August 2015 PMID 25957282

Activation of autophagy in human skeletal muscle is dependent on exercise intensity and AMPK activation.

Céline Schwalm, Cécile Jamart, Nicolas Benoit, Damien Naslain, Christophe Prémont, Jérémy Prévet, Ruud Van Thienen, Louise Deldicque, Marc Francaux

Mentions

87
Peak: 13 in Jun 2022
across 5 sources since Apr 2019

Extended reach

1,879,002
potential audience

Total likes

561

Video views

2,744

Mentions per month

Apr 2019 – Mar 2025

Where it's discussed

  • X / Twitter76 posts
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AI synopsis

What people are saying

The overall tone shows enthusiastic support for the idea that exercise heightens autophagy, with many posts citing the importance of exercise intensity and molecular factors like AMPK, suggesting a recognition of the study’s significance in understanding muscle health and aging. Words like 'powerful,' 'most effective,' and 'activation' reflect a tone of validation and emphasis on real-world applications, indicating strong deep engagement and perceived high impact.

AgreementStrong agreement

Most discussions emphasize the strong relationship between exercise intensity and autophagy activation, clearly supporting the publication's findings.

InterestModerate interest

There is moderate interest, with many acknowledging the significance of exercise for cellular health but not delving into detailed mechanisms.

EngagementHigh engagement

Posts show deep engagement by referencing molecular details like AMPK activation and discussing implications for health and fitness.

ImpactHigh impact

Participants believe the research has high impact, highlighting exercise as a powerful tool for muscle health, thereby influencing fitness strategies.

Abstract in brief

  • The study found that both fasting and high-intensity exercise activate autophagy in human skeletal muscle, with the strongest effect observed after high-intensity exercise.
  • Indicators such as increased phosphorylation of ULK1 and decreased levels of autophagy markers like LC3b and p62 suggest that autophagic flux is higher following high-intensity activity, especially in fasting conditions.
  • The activation of autophagy appears to be linked to increased AMPK activity, which was higher after high-intensity exercise, indicating that exercise intensity plays a more critical role than diet in stimulating muscle autophagy.]

Top posts

Most liked on X and Bluesky
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

Exercise is also a powerful way to increase autophagy, perhaps even more powerful than short-term fasting. The higher the exercise intensity, the higher the autophagy activation. https://t.co/l4fnbwkK1g

Mar 5, 2021 · 208 likes · 20 shares · 295,571 followers View post →
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

Activation of autophagy in human skeletal muscle is dependent on exercise intensity and AMPK activation "the most effective strategy to activate autophagy in human skeletal muscle seems to rely on exercise intensity more than diet" https://t.co/j8kmDO3P6U

Oct 27, 2019 · 106 likes · 10 shares · 295,571 followers View post →
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

Activation of autophagy in human skeletal muscle is dependent on exercise intensity and AMPK activation High intensity exercise activated AMPK, a key molecular sensor in lifespan and healthspan, more than low intensity. https://t.co/OJyLHvZF0U

Jun 12, 2022 · 88 likes · 13 shares · 295,571 followers View post →
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

Activation of autophagy in human skeletal muscle is dependent on exercise intensity and AMPK activation https://t.co/QGuUt1WnQT

Apr 23, 2019 · 40 likes · 8 shares · 295,571 followers View post →
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

High intensity exercise activates autophagy more than low intensity. https://t.co/OJyLHvZF0U

Jun 25, 2020 · 38 likes · 10 shares · 295,571 followers View post →
Hábitos 5 punto 0
@Habitos5punto0 · X

El ejercicio induce autofagia en tejidos periféricos y cerebro: https://t.co/yXLRVs5fhg Ejercicio, autofagia y apoptosis https://t.co/3Adk0mSibf Mitofagia en personas mayores: efectos del ejercicio https://t.co/2leVmtuKR0 Autofagia e intensidad de ej https://t.co/5dp4DAS7MJ

Mar 4, 2022 · 14 likes · 6 shares · 33,604 followers View post →

All mentions

Linda Eyring
@LyndaMargee · X

RT @Mangan150: Exercise is also a powerful way to increase autophagy, perhaps even more powerful than short-term fasting. The higher the e…

Mar 8, 2025 · 20 shares · 1,890 followers View post →
Architect Neo
@Neo1Architect · X

Η άσκηση είναι επίσης ένας ισχυρός τρόπος για την αύξηση της αυτοφαγίας, ίσως ακόμη πιο ισχυρός από τη βραχυπρόθεσμη νηστεία. Όσο μεγαλύτερη είναι η ένταση της άσκησης, τόσο μεγαλύτερη είναι η ενεργοποίηση της αυτοφαγίας.⏬ https://t.co/uRhTeSgkcw

Feb 6, 2025 · 4 likes · 525 followers View post →
Kirsty Woods
@MetabolicEP · X

Fasting alone not enough? https://t.co/lyh6tApzy8

Nov 29, 2024 · 1 like · 2,043 followers View post →
Jas. Leading Hordes to Data Won't make them Think.
@JasSpin1 · X

RT @Mangan150: Exercise is also a powerful way to increase autophagy, perhaps even more powerful than short-term fasting. The higher the e…

Oct 27, 2024 · 20 shares · 2,327 followers View post →
TLB
@TLB_Thinks · X

Check out this study on how exercise activates autophagy more than diet: https://t.co/0EgX857zjq

Oct 11, 2024 · 42 followers View post →
TLB
@TLB_Thinks · X

Curious about how exercise triggers your body’s cellular ‘cleanup’? Check out these studies: • https://t.co/0EgX857zjq • https://t.co/wge3i8ijgR • https://t.co/DkwGcyY3TZ Inspirational blog post with more information: https://t.co/St3nGKwIqU

Sep 24, 2024 · 42 followers View post →
drehman ☕️#ReadWriteThinkCriticallyDaily
@pomdr · X

Instead of fasting, research has found that cutting calories is just as effective as time-restricted eating. —The Daily Pump @Schwarzenegger @BornFitness @ketch https://t.co/yPDkoRMpm4 https://t.co/QWEcuYVQZP

Sep 24, 2024 · 593 followers View post →
Michael Huerta
@M_T_Huerta · X

RT @Mangan150: Exercise is also a powerful way to increase autophagy, perhaps even more powerful than short-term fasting. The higher the e…

Mar 8, 2024 · 20 shares · 448 followers View post →
Purplebutterfly
@GHerman527 · X

RT @Mangan150: Exercise is also a powerful way to increase autophagy, perhaps even more powerful than short-term fasting. The higher the e…

Dec 24, 2023 · 20 shares · 1,495 followers View post →
Holly Loves Chows
@ChowsHolly · X

RT @Mangan150: Exercise is also a powerful way to increase autophagy, perhaps even more powerful than short-term fasting. The higher the e…

Oct 3, 2023 · 20 shares · 383 followers View post →
Criscella
@CriscellaTX · X

RT @Mangan150: Exercise is also a powerful way to increase autophagy, perhaps even more powerful than short-term fasting. The higher the e…

Oct 2, 2023 · 20 shares · 306 followers View post →
H Nairobian
@HNairobian · X

RT @Mangan150: Exercise is also a powerful way to increase autophagy, perhaps even more powerful than short-term fasting. The higher the e…

Oct 2, 2023 · 20 shares · 33 followers View post →
tokatti
@tokatti_ · X

オートファジーをオンにするためにもっとも効果的な方法は、食事よりもエクササイズ 運動の負荷が高いほど効果あり https://t.co/Ll9YrftcdT 2016年のワシントン大学の研究 37人のカロリーリストリクション実践者を対象にした だいたい3〜15年の長さでカロリーリストリクションをしていて、同じ体型の

Aug 18, 2023 · 189 followers View post →
Pietro Bianchin ✝️
@bianchin_pietro · X

RT @Mangan150: Exercise is also a powerful way to increase autophagy, perhaps even more powerful than short-term fasting. The higher the e…

Feb 26, 2023 · 20 shares · 370 followers View post →
Jas. Leading Hordes to Data Won't make them Think.
@JasSpin1 · X

RT @Mangan150: Exercise is also a powerful way to increase autophagy, perhaps even more powerful than short-term fasting. The higher the e…

Feb 11, 2023 · 20 shares · 2,327 followers View post →
Wayne Small
@waynemystir · X

RT @Mangan150: Exercise is also a powerful way to increase autophagy, perhaps even more powerful than short-term fasting. The higher the e…

Nov 25, 2022 · 20 shares · 890 followers View post →
くわお
@kuwao_beauty888 · X

@tad_fasting Tad0429さん✨ オートファジーは断食などの空腹だけでなく運動においても起きます。ようは身体の細胞に喝を入れるイメージ。 断食と運動では効果は運動の圧勝なんです

Jul 28, 2022 · 1 like · 3,965 followers View post →
ConcernedCitizen.io
@Serious_Serb · X

RT @Mangan150: Activation of autophagy in human skeletal muscle is dependent on exercise intensity and AMPK activation High intensity exer…

Jun 13, 2022 · 13 shares · 3,247 followers View post →
leelenton
@leelenton · X

RT @Mangan150: Activation of autophagy in human skeletal muscle is dependent on exercise intensity and AMPK activation High intensity exer…

Jun 12, 2022 · 13 shares · 577 followers View post →
Bitcoin Érick ∞/21M
@bitcoinerick · X

RT @Mangan150: Activation of autophagy in human skeletal muscle is dependent on exercise intensity and AMPK activation High intensity exer…

Jun 12, 2022 · 13 shares · 1,400 followers View post →
Murphy Arana
@AranaMurphy · X

RT @Mangan150: Activation of autophagy in human skeletal muscle is dependent on exercise intensity and AMPK activation High intensity exer…

Jun 12, 2022 · 13 shares · 37 followers View post →
Dr Sam Pappas
@DrSamPappas · X

RT @Mangan150: Activation of autophagy in human skeletal muscle is dependent on exercise intensity and AMPK activation High intensity exer…

Jun 12, 2022 · 13 shares · 2,099 followers View post →
Rafael Jodeskleydson
@Rafaeljodes · X

RT @Mangan150: Activation of autophagy in human skeletal muscle is dependent on exercise intensity and AMPK activation High intensity exer…

Jun 12, 2022 · 13 shares · 379 followers View post →
Chris Birklan
@BirklandChris · X

RT @Mangan150: Activation of autophagy in human skeletal muscle is dependent on exercise intensity and AMPK activation High intensity exer…

Jun 12, 2022 · 13 shares · 685 followers View post →
Dr. Edward Trausti
@Alfred_The_Okay · X

RT @Mangan150: Activation of autophagy in human skeletal muscle is dependent on exercise intensity and AMPK activation High intensity exer…

Jun 12, 2022 · 13 shares · 14 followers View post →
kike
@FUENTESMANZULLI · X

RT @Mangan150: Activation of autophagy in human skeletal muscle is dependent on exercise intensity and AMPK activation High intensity exer…

Jun 12, 2022 · 13 shares · 249 followers View post →
Mercantile Mindset
@Tb33648182 · X

RT @Mangan150: Activation of autophagy in human skeletal muscle is dependent on exercise intensity and AMPK activation High intensity exer…

Jun 12, 2022 · 13 shares · 114 followers View post →
TK
@Kreutzjr1 · X

RT @Mangan150: Activation of autophagy in human skeletal muscle is dependent on exercise intensity and AMPK activation High intensity exer…

Jun 12, 2022 · 13 shares · 1,626 followers View post →
Kal
@Winters96310300 · X

RT @Mangan150: Activation of autophagy in human skeletal muscle is dependent on exercise intensity and AMPK activation High intensity exer…

Jun 12, 2022 · 13 shares · 1,382 followers View post →
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

Activation of autophagy in human skeletal muscle is dependent on exercise intensity and AMPK activation High intensity exercise activated AMPK, a key molecular sensor in lifespan and healthspan, more than low intensity. https://t.co/OJyLHvZF0U

Jun 12, 2022 · 88 likes · 13 shares · 295,571 followers View post →
Xavier Gonzalez
@fxxxavierrr · X

RT @AAlos40: El ejercicio induce autofagia en tejidos periféricos y cerebro: https://t.co/yXLRVs5fhg Ejercicio, autofagia y apoptosis http…

Apr 16, 2022 · 6 shares · 206 followers View post →
Osmel Hernandez
@osmeloxs · X

RT @AAlos40: El ejercicio induce autofagia en tejidos periféricos y cerebro: https://t.co/yXLRVs5fhg Ejercicio, autofagia y apoptosis http…

Mar 4, 2022 · 6 shares · 290 followers View post →
Juan Garabeti
@JGarabeti · X

RT @AAlos40: El ejercicio induce autofagia en tejidos periféricos y cerebro: https://t.co/yXLRVs5fhg Ejercicio, autofagia y apoptosis http…

Mar 4, 2022 · 6 shares · 138 followers View post →
Negrita
@Makana20201 · X

RT @AAlos40: El ejercicio induce autofagia en tejidos periféricos y cerebro: https://t.co/yXLRVs5fhg Ejercicio, autofagia y apoptosis http…

Mar 4, 2022 · 6 shares · 30 followers View post →
Marina
@cansada11869 · X

RT @AAlos40: El ejercicio induce autofagia en tejidos periféricos y cerebro: https://t.co/yXLRVs5fhg Ejercicio, autofagia y apoptosis http…

Mar 4, 2022 · 6 shares · 207 followers View post →
Luis Alonso
@luis_alonso_g · X

RT @AAlos40: El ejercicio induce autofagia en tejidos periféricos y cerebro: https://t.co/yXLRVs5fhg Ejercicio, autofagia y apoptosis http…

Mar 4, 2022 · 6 shares · 74 followers View post →
Hábitos 5 punto 0
@Habitos5punto0 · X

El ejercicio induce autofagia en tejidos periféricos y cerebro: https://t.co/yXLRVs5fhg Ejercicio, autofagia y apoptosis https://t.co/3Adk0mSibf Mitofagia en personas mayores: efectos del ejercicio https://t.co/2leVmtuKR0 Autofagia e intensidad de ej https://t.co/5dp4DAS7MJ

Mar 4, 2022 · 14 likes · 6 shares · 33,604 followers View post →
H Nairobian
@HNairobian · X

RT @Mangan150: Exercise is also a powerful way to increase autophagy, perhaps even more powerful than short-term fasting. The higher the e…

Jan 8, 2022 · 20 shares · 33 followers View post →
optimyystique
@optimyystique · X

RT @Mangan150: Exercise is also a powerful way to increase autophagy, perhaps even more powerful than short-term fasting. The higher the e…

Jan 8, 2022 · 20 shares · 72 followers View post →
Khaleesi
@aishlingmara · X

RT @Mangan150: Exercise is also a powerful way to increase autophagy, perhaps even more powerful than short-term fasting. The higher the e…

May 6, 2021 · 20 shares · 3,370 followers View post →
Joseph Evans
@Odote · X

RT @Mangan150: Exercise is also a powerful way to increase autophagy, perhaps even more powerful than short-term fasting. The higher the e…

May 5, 2021 · 20 shares · 1,727 followers View post →
David
@dchrist81 · X

RT @Mangan150: Exercise is also a powerful way to increase autophagy, perhaps even more powerful than short-term fasting. The higher the e…

Apr 3, 2021 · 20 shares · 1,581 followers View post →
Kuki Muki
@kukimuki99 · X

RT @Mangan150: Exercise is also a powerful way to increase autophagy, perhaps even more powerful than short-term fasting. The higher the e…

Mar 30, 2021 · 20 shares · 213 followers View post →
Rakan I. Nazer راكان بن ابراهيم ناظر
@RakanINazer · X

RT @Mangan150: Exercise is also a powerful way to increase autophagy, perhaps even more powerful than short-term fasting. The higher the e…

Mar 5, 2021 · 20 shares · 10,180 followers View post →
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

Exercise is also a powerful way to increase autophagy, perhaps even more powerful than short-term fasting. The higher the exercise intensity, the higher the autophagy activation. https://t.co/l4fnbwkK1g

Mar 5, 2021 · 208 likes · 20 shares · 295,571 followers View post →
ilona kasza
@babilon1271 · X

RT @Mangan150: High intensity exercise activates autophagy more than low intensity. https://t.co/OJyLHvZF0U

Jun 26, 2020 · 10 shares · 204 followers View post →
Adi
@Adrian06661136 · X

RT @Mangan150: High intensity exercise activates autophagy more than low intensity. https://t.co/OJyLHvZF0U

Jun 26, 2020 · 10 shares · 483 followers View post →
pōhutukawa
@pohutukawa · X

RT @Mangan150: High intensity exercise activates autophagy more than low intensity. https://t.co/OJyLHvZF0U

Jun 25, 2020 · 10 shares · 576 followers View post →
laili
@laili_lai · X

RT @Mangan150: High intensity exercise activates autophagy more than low intensity. https://t.co/OJyLHvZF0U

Jun 25, 2020 · 10 shares · 68 followers View post →
Bernie
@miseenplace86 · X

RT @Mangan150: High intensity exercise activates autophagy more than low intensity. https://t.co/OJyLHvZF0U

Jun 25, 2020 · 10 shares · 110 followers View post →
Ana Cláudia
@Anawsantos · X

RT @Mangan150: High intensity exercise activates autophagy more than low intensity. https://t.co/OJyLHvZF0U

Jun 25, 2020 · 10 shares · 362 followers View post →
Deborah Gordon, M.D.
@DrDeborahMD · X

RT @Mangan150: High intensity exercise activates autophagy more than low intensity. https://t.co/OJyLHvZF0U

Jun 25, 2020 · 10 shares · 3,762 followers View post →
Lαzαɾմs
@gran1_ly · X

RT @Mangan150: High intensity exercise activates autophagy more than low intensity. https://t.co/OJyLHvZF0U

Jun 25, 2020 · 10 shares · 211 followers View post →
Michael
@mst4truth · X

RT @Mangan150: High intensity exercise activates autophagy more than low intensity. https://t.co/OJyLHvZF0U

Jun 25, 2020 · 10 shares · 805 followers View post →
Dave
@DaveUtterback · X

RT @Mangan150: High intensity exercise activates autophagy more than low intensity. https://t.co/OJyLHvZF0U

Jun 25, 2020 · 10 shares · 61 followers View post →
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

High intensity exercise activates autophagy more than low intensity. https://t.co/OJyLHvZF0U

Jun 25, 2020 · 38 likes · 10 shares · 295,571 followers View post →
Suzanne (Zan) Dixon (MPH, MS, RD)
@NoNutritionFear · X

@StephHfitness Here's one: https://t.co/qMHHHPdnyW

Jan 12, 2020 · 2 likes · 1,047 followers View post →
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

@jaimeraulmolina Not sure if these fit the bill but a couple https://t.co/idjnQOcjto https://t.co/j8kmDO3P6U

Dec 27, 2019 · 2 likes · 295,571 followers View post →
NordicWellnessGroup
@nordicwell · X

RT @Mangan150: Activation of autophagy in human skeletal muscle is dependent on exercise intensity and AMPK activation "the most effective…

Oct 29, 2019 · 10 shares · 503 followers View post →
Adi
@Adrian06661136 · X

RT @Mangan150: Activation of autophagy in human skeletal muscle is dependent on exercise intensity and AMPK activation "the most effective…

Oct 28, 2019 · 10 shares · 483 followers View post →
中武 壮以知
@soichinakatake · X

「オートファジーをアクティブにする最も効果的な戦略は、食事の供給ではなく運動強度に依存する」との事です。オートファジーのためには断食より運動が効率的。 Activation of autophagy in human skeletal muscle is dependent on exercise intensity and AMPK activation https://t.co/oJtlnORchh

Oct 27, 2019 · 137 followers View post →
MF
@MFraylick · X

RT @Mangan150: Activation of autophagy in human skeletal muscle is dependent on exercise intensity and AMPK activation "the most effective…

Oct 27, 2019 · 10 shares · 678 followers View post →
Federico Bernuzzi, PhD
@FedericoBernuzz · X

RT @Mangan150: Activation of autophagy in human skeletal muscle is dependent on exercise intensity and AMPK activation "the most effective…

Oct 27, 2019 · 10 shares · 621 followers View post →
@partizan@twiukraine.com
@partizan · X

RT @Mangan150: Activation of autophagy in human skeletal muscle is dependent on exercise intensity and AMPK activation "the most effective…

Oct 27, 2019 · 10 shares · 681 followers View post →
James Wright
@JamesGaius · X

RT @Mangan150: Activation of autophagy in human skeletal muscle is dependent on exercise intensity and AMPK activation "the most effective…

Oct 27, 2019 · 10 shares · 479 followers View post →
Paul
@GulagAgos · X

RT @Mangan150: Activation of autophagy in human skeletal muscle is dependent on exercise intensity and AMPK activation "the most effective…

Oct 27, 2019 · 10 shares · 151 followers View post →
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

Activation of autophagy in human skeletal muscle is dependent on exercise intensity and AMPK activation "the most effective strategy to activate autophagy in human skeletal muscle seems to rely on exercise intensity more than diet" https://t.co/j8kmDO3P6U

Oct 27, 2019 · 106 likes · 10 shares · 295,571 followers View post →
m73fitness
@m73fitness · X

RT @Mangan150: Activation of autophagy in human skeletal muscle is dependent on exercise intensity and AMPK activation https://t.co/QGuUt1…

May 18, 2019 · 8 shares · 169 followers View post →
Alex
@AlexViKu · X

Activation of autophagy in human skeletal muscle is dependent on exercise intensity and AMPK activation/ 2015 https://t.co/EtWwy943wl

Apr 28, 2019 · 1 like · 96 followers View post →
No Quarter
@loganeliaslee · X

RT @Mangan150: Activation of autophagy in human skeletal muscle is dependent on exercise intensity and AMPK activation https://t.co/QGuUt1…

Apr 24, 2019 · 8 shares · 535 followers View post →
H101
@Lchf_Dude · X

RT @Mangan150: Activation of autophagy in human skeletal muscle is dependent on exercise intensity and AMPK activation https://t.co/QGuUt1…

Apr 24, 2019 · 8 shares · 23 followers View post →
Basanta Kumar Rout
@rout_basanta · X

RT @Mangan150: Activation of autophagy in human skeletal muscle is dependent on exercise intensity and AMPK activation https://t.co/QGuUt1…

Apr 23, 2019 · 8 shares · 355 followers View post →
Mass Migration
@BChinatti · X

RT @Mangan150: Activation of autophagy in human skeletal muscle is dependent on exercise intensity and AMPK activation https://t.co/QGuUt1…

Apr 23, 2019 · 8 shares · 1,204 followers View post →
Paul
@GulagAgos · X

RT @Mangan150: Activation of autophagy in human skeletal muscle is dependent on exercise intensity and AMPK activation https://t.co/QGuUt1…

Apr 23, 2019 · 8 shares · 151 followers View post →
MMA and Boxing Fight Analyst
@kostasfant · X

RT @Mangan150: Activation of autophagy in human skeletal muscle is dependent on exercise intensity and AMPK activation https://t.co/QGuUt1…

Apr 23, 2019 · 8 shares · 5,826 followers View post →
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

Activation of autophagy in human skeletal muscle is dependent on exercise intensity and AMPK activation https://t.co/QGuUt1WnQT

Apr 23, 2019 · 40 likes · 8 shares · 295,571 followers View post →