5/ Mais son indication reine est surtout l’insuffisance respiratoire aiguë hypoxémique du patient GRAVE (vous me direz ça tombe bien) https://t.co/7T1nXSqdr9
High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure.
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Feb 2019 – May 2025Where it's discussed
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What people are saying
The overall tone demonstrates strong support and interest, citing specific trial results such as lower 90-day mortality rates with high-flow oxygen and its superiority over other forms like NIV, which are highlighted by words like 'solid' and 'benefits.' The recognition of the trial's influence on practice and detailed analysis of its findings contribute to high engagement and perceived impact.
Most discussions support the findings of the FLORALI trial, emphasizing the benefits of high-flow nasal cannula and its role in reducing mortality and intubation.
The discussions indicate high engagement with detailed references to trial results, implications for practice, and diverse perspectives, showing strong interest.
Posts analyze the trial's methods, compare it to other studies, and consider its implications, reflecting deep engagement.
User comments suggest that the findings influence clinical decision-making, with some highlighting the potential to change treatment strategies significantly.
Abstract in brief
- The study investigates whether high-flow oxygen therapy is a better option compared to standard oxygen therapy and noninvasive ventilation for patients with acute hypoxemic respiratory failure, focusing on intubation rates and mortality outcomes.*
- In a trial involving 310 patients, the intubation rates were similar across all three treatment groups, but the high-flow oxygen group had the most ventilator-free days (24 days) compared to the other methods.*
- Findings suggest that while intubation rates did not significantly differ, high-flow oxygen therapy was associated with lower 90-day mortality rates compared to standard oxygen and noninvasive ventilation.*
Top posts
Most liked on X and Bluesky@mongenwu @chhoaniau 目前還沒有看到已經發表的針對 COVID-19 的 High flow oxygenation 臨床實驗。 我們認為會有效,主要是因為2015 年 NEJM 這篇:在肺炎造成缺氧性呼吸衰竭的患者,HFNC 有效降低死亡率與進展成需要侵襲性呼吸器的患者比例。 https://t.co/d3TWmjTvDm https://t.co/lq1sFNgye1
Also use HFNC to prevent intubation! https://t.co/GZTKEANnJj
The FLORALI study (DOI:10.1056/NEJMoa1503326) in 2015 showed that in hypoxemic resp failure, there was no difference in intubation rates (HFNC 38%, Face mask 47%, NIV 50%) BUT ventilator-free ds at d28 were ⬆️ (good!) in the HFNC group; there was also sig diff in favor of HFNC... https://t.co/PdP77g7b2A
The FLORALI trial might add some indirect evidence of this. BIPAP provides pressure support so; If pt has a high respiratory drive, BIPAP could actually worsen P-SILI. CPAP is not expected to do this. HFNC by reducing dead space can reduce WOB. 10.1056/NEJMoa1503326 (13) https://t.co/P9Rx0L5Fl2
Le niveau de preuve de l’efficacité de l’oxygénation à haut débit dans les pneumonies graves est bon (cf essai FLORALI https://t.co/ZBb2JGgxZg . Cette technique permet d’éviter parfois le recours à l’intubation (technique plus invasive).
All mentions
High-Flow Nasal Oxygen in Hypoxemic Respiratory Failure: Critical Insights
The FLORALI trial was a landmark study examining high-flow nasal oxygen in acute hypoxemic respiratory failure. It highlighted that in sicker patients, high-flow therapy reduced intubation and mortality, emphasizing its…
Advances and Paradigms in Ventilatory Support for ARDS Patients
This episode features expert Ft Andr Nascimento discussing recent advances in ventilatory assistance and management of respiratory failure. He reviews strategies impacting clinical outcomes, different support…
Ce genre de patient hypoxemique pur est l’archétype du patient de l’étude FLORALI https://t.co/VjadfD6tJ7 , arrêtez avec la VNI (le tirage clinique n’est pas une indication d’Aide Inspiratoire) ..si il s’aggrave sous OHD, intubez le (VNI autorisée si juste pour pré-ox, of course)
RT @tipssovetorax: RECORDAR. Estudio FLORI. Oxígeno de alto flujo a través de la cánula nasal en la insuficiencia respiratoria hipoxémica a…
RT @tipssovetorax: RECORDAR. Estudio FLORI. Oxígeno de alto flujo a través de la cánula nasal en la insuficiencia respiratoria hipoxémica a…
RT @tipssovetorax: RECORDAR. Estudio FLORI. Oxígeno de alto flujo a través de la cánula nasal en la insuficiencia respiratoria hipoxémica a…
RECORDAR. Estudio FLORI. Oxígeno de alto flujo a través de la cánula nasal en la insuficiencia respiratoria hipoxémica aguda https://t.co/D3jCzZ0xTw
#TrialOfTheDay for May 16th is the FLORALI trial. This trial compared how we deliver oxygen in AHRF Open Access Article Link: https://t.co/UZ0KBo7XLb #pharmicu #pharmed #emrx #twitterx #pulmtwitter #medtwitter #foamed #foamcc #meded #some https://t.co/BH7ivNRbXl
RT @iceman_ex: Sorry @dfmcauley I only had 4 options so couldn’t stick awake proning in…. And once again the love for HFNC wins through. D…
RT @iceman_ex: Sorry @dfmcauley I only had 4 options so couldn’t stick awake proning in…. And once again the love for HFNC wins through. D…
Sorry @dfmcauley I only had 4 options so couldn’t stick awake proning in…. And once again the love for HFNC wins through. Did FLORALI win over so many hearts and minds? https://t.co/7QtSQdB7Am #ardstalk https://t.co/7oDBpsxRod https://t.co/YeRPsbXGE6
@Paul_Wischmeyer @NEJM @lancet @TheLancet TTM https://t.co/eHhhSzp4Xa 3 SITES https://t.co/Ye3HT0Yw7u FLORALI https://t.co/vYpacvRb5x SAPS https://t.co/hn0GpNolID
Our next #justthegist email #journalclub is brought to you by @asha_anandaiah @HarvardPulm @NEJM Check out full article here: https://t.co/wjbEAIGCcR https://t.co/OMtfCA8C3q
FLORALI - 2015 - FM vs HFNO vs NIV in non intubated ARDS - ∅rates of IPPV ↓90d mortality in HFNO - https://t.co/gzKFz8ORxa
FLORALI - 2015 - FM vs HFNO vs NIV in non intubated ARDS - ∅rates of IPPV ↓90d mortality in HFNO - https://t.co/gzKFz8ORxa
https://t.co/8Y1X8qMdi5 Fret - original paper -- high flow has benefits.
FLORALI - 2015 - FM vs HFNO vs NIV in non intubated ARDS - ∅rates of IPPV ↓90d mortality in HFNO - https://t.co/gzKFz8PpmI
3️⃣ wrong comparator - most patients (84%) in the standard of care group received HFNC. We know from the FLORALI trial that HFNC is *superior* to NIPPV at preventing intubations. A better interface probably can’t overcome this inherent disadvantage. https://t.co/b1XssqWoMO 9/ https://t.co/EdC7ThDwcV
FLORALI trial referenced during #criticalmedboston High-Flow Oxygen through Nasal Cannula in Acute Hypoxemic Respiratory Failure | NEJM https://t.co/YMKaBrzkdX
FLORALI - 2015 - FM vs HFNO vs NIV in non intubated ARDS - ∅rates of IPPV ↓90d mortality in HFNO - https://t.co/gzKFz8ORxa
FLORALI - 2015 - FM vs HFNO vs NIV in non intubated ARDS - ∅rates of IPPV ↓90d mortality in HFNO - https://t.co/gzKFz8ORxa
FLORALI - 2015 - FM vs HFNO vs NIV in non intubated ARDS - ∅rates of IPPV ↓90d mortality in HFNO - https://t.co/gzKFz8PpmI
RT @JayHineMD: I was less than familiar with this trial. Pretty solid. Reach for HiFlo. https://t.co/6ozOPPaeYm #AAEM22 https://t.co/eI0N…
I was less than familiar with this trial. Pretty solid. Reach for HiFlo. https://t.co/6ozOPPaeYm #AAEM22 https://t.co/eI0NoI4AaU
I was less than familiar with this trial. Pretty solid. Reach for HiFlo. https://t.co/6ozOPPaeYm #AAEM22 https://t.co/cRD1pTuvpn
FLORALI - 2015 - FM vs HFNO vs NIV in non intubated ARDS - ∅rates of IPPV ↓90d mortality in HFNO - https://t.co/gzKFz8ORxa
FLORALI - 2015 - FM vs HFNO vs NIV in non intubated ARDS - ∅rates of IPPV ↓90d mortality in HFNO - https://t.co/gzKFz8ORxa
FLORALI - 2015 - FM vs HFNO vs NIV in non intubated ARDS - ∅rates of IPPV ↓90d mortality in HFNO - https://t.co/gzKFz8ORxa
2015年のFLORALIstudyだとⅠ型呼吸不全に対してVS NPPVで成績よかったけど、Ⅱ型呼吸不全だとどうだろうか。ちらほら文献でてるみたいだけど。 https://t.co/K8UTJFi4fx
RT @tjcjqps: #jointcommissionjournal #highflowoxygen @NEJM https://t.co/jlKynXoAkH
#jointcommissionjournal #highflowoxygen @NEJM https://t.co/jlKynXoAkH
Summary from Morgan Soffler at #criticalmedboston of the FLORALI Trial - https://t.co/ETbTDmXhWY @NEJM #HFNC https://t.co/F22To0MB2F
FLORALI - 2015 - FM vs HFNO vs NIV in non intubated ARDS - ∅rates of IPPV ↓90d mortality in HFNO - https://t.co/gzKFz8ORxa
RT @IM_Crit_: The FLORALI study (DOI:10.1056/NEJMoa1503326) in 2015 showed that in hypoxemic resp failure, there was no difference in intub…
RT @IM_Crit_: The FLORALI study (DOI:10.1056/NEJMoa1503326) in 2015 showed that in hypoxemic resp failure, there was no difference in intub…
RT @IM_Crit_: The FLORALI study (DOI:10.1056/NEJMoa1503326) in 2015 showed that in hypoxemic resp failure, there was no difference in intub…
RT @IM_Crit_: The FLORALI study (DOI:10.1056/NEJMoa1503326) in 2015 showed that in hypoxemic resp failure, there was no difference in intub…
RT @IM_Crit_: The FLORALI study (DOI:10.1056/NEJMoa1503326) in 2015 showed that in hypoxemic resp failure, there was no difference in intub…
RT @IM_Crit_: The FLORALI study (DOI:10.1056/NEJMoa1503326) in 2015 showed that in hypoxemic resp failure, there was no difference in intub…
The FLORALI study (DOI:10.1056/NEJMoa1503326) in 2015 showed that in hypoxemic resp failure, there was no difference in intubation rates (HFNC 38%, Face mask 47%, NIV 50%) BUT ventilator-free ds at d28 were ⬆️ (good!) in the HFNC group; there was also sig diff in favor of HFNC... https://t.co/PdP77g7b2A
RT @isawamaho: @mongenwu @chhoaniau 目前還沒有看到已經發表的針對 COVID-19 的 High flow oxygenation 臨床實驗。 我們認為會有效,主要是因為2015 年 NEJM 這篇:在肺炎造成缺氧性呼吸衰竭的患者,HFNC…
RT @isawamaho: @mongenwu @chhoaniau 目前還沒有看到已經發表的針對 COVID-19 的 High flow oxygenation 臨床實驗。 我們認為會有效,主要是因為2015 年 NEJM 這篇:在肺炎造成缺氧性呼吸衰竭的患者,HFNC…
RT @isawamaho: @mongenwu @chhoaniau 目前還沒有看到已經發表的針對 COVID-19 的 High flow oxygenation 臨床實驗。 我們認為會有效,主要是因為2015 年 NEJM 這篇:在肺炎造成缺氧性呼吸衰竭的患者,HFNC…
RT @isawamaho: @mongenwu @chhoaniau 目前還沒有看到已經發表的針對 COVID-19 的 High flow oxygenation 臨床實驗。 我們認為會有效,主要是因為2015 年 NEJM 這篇:在肺炎造成缺氧性呼吸衰竭的患者,HFNC…
@mongenwu @chhoaniau 目前還沒有看到已經發表的針對 COVID-19 的 High flow oxygenation 臨床實驗。 我們認為會有效,主要是因為2015 年 NEJM 這篇:在肺炎造成缺氧性呼吸衰竭的患者,HFNC 有效降低死亡率與進展成需要侵襲性呼吸器的患者比例。 https://t.co/d3TWmjTvDm https://t.co/lq1sFNgye1
RT @intensivecare_c: FLORALI以降、低酸素性呼吸不全にはHFNCの方がNIVよりも良いとされてきたので、興味深い結果です。 FLORALIはこちら https://t.co/qU8ERy0iDv
FLORALI - 2015 - FM vs HFNO vs NIV in non intubated ARDS - ∅rates of IPPV ↓90d mortality in HFNO - https://t.co/gzKFz8ORxa
RT @MisterBrown82: 5/ Mais son indication reine est surtout l’insuffisance respiratoire aiguë hypoxémique du patient GRAVE (vous me direz ç…
5/ Mais son indication reine est surtout l’insuffisance respiratoire aiguë hypoxémique du patient GRAVE (vous me direz ça tombe bien) https://t.co/7T1nXSqdr9
RT @intensivecare_c: FLORALI以降、低酸素性呼吸不全にはHFNCの方がNIVよりも良いとされてきたので、興味深い結果です。 FLORALIはこちら https://t.co/qU8ERy0iDv
FLORALI以降、低酸素性呼吸不全にはHFNCの方がNIVよりも良いとされてきたので、興味深い結果です。 FLORALIはこちら https://t.co/qU8ERy0iDv
@MDaware @emily_fri @EMHighAK @elewMD @TheShenger @drjgutt @SkylerLentz @rbyyny @sreeja_natesan @MprizzleER @alvarezzzy @kaynani32 @MikePallaci @Chris_McStay @NotSoLilMD @ShehniNadeem @HeyDrNik @ResusOne @davidcarr333 FLORALI https://t.co/S4Onhm6KET
The management of Acute Chest Syndrome is mainly supportive, the need for IMV is associated with higher mortality, likely because of a reflection of higher disease severity. HFNC is superior to NIVPPV in these patients. #SickleCell #CHESTCritCare https://t.co/5VWT6DueK6
FLORALI - 2015 - FM vs HFNO vs NIV in non intubated ARDS - ∅rates of IPPV ↓90d mortality in HFNO - https://t.co/gzKFz8ORxa
FLORALI - 2015 - FM vs HFNO vs NIV in non intubated ARDS - ∅rates of IPPV ↓90d mortality in HFNO - https://t.co/gzKFz8ORxa
FLORALI - 2015 - FM vs HFNO vs NIV in non intubated ARDS - ∅rates of IPPV ↓90d mortality in HFNO - https://t.co/gzKFz8ORxa
FLORALI - 2015 - FM vs HFNO vs NIV in non intubated ARDS - ∅rates of IPPV ↓90d mortality in HFNO - https://t.co/gzKFz8ORxa
FLORALI - 2015 - FM vs HFNO vs NIV in non intubated ARDS - ∅rates of IPPV ↓90d mortality in HFNO - https://t.co/gzKFz8ORxa
FLORALI - 2015 - FM vs HFNO vs NIV in non intubated ARDS - ∅rates of IPPV ↓90d mortality in HFNO - https://t.co/gzKFz8ORxa
FLORALI - 2015 - FM vs HFNO vs NIV in non intubated ARDS - ∅rates of IPPV ↓90d mortality in HFNO - https://t.co/gzKFz8ORxa
FLORALI trial here: https://t.co/ETbTDmXhWY @asha_anandaiah is discussing this now and #criticalmedboston director, @MSoffler, is going to build on this talk and take it to another level soon! @HarvardPulm
https://t.co/oKdRMHWqcb
High-Flow Oxygen through Nasal Cannula in Acute Hypoxemic Respiratory Failure | NEJM https://t.co/oKdRMHWqcb
FLORALI - 2015 - FM vs HFNO vs NIV in non intubated ARDS - ∅rates of IPPV ↓90d mortality in HFNO - https://t.co/gzKFz8ORxa
RT @StephaneG05: Le niveau de preuve de l’efficacité de l’oxygénation à haut débit dans les pneumonies graves est bon (cf essai FLORALI h…
Le niveau de preuve de l’efficacité de l’oxygénation à haut débit dans les pneumonies graves est bon (cf essai FLORALI https://t.co/ZBb2JGgxZg . Cette technique permet d’éviter parfois le recours à l’intubation (technique plus invasive).
FLORALI - 2015 - FM vs HFNO vs NIV in non intubated ARDS - ∅rates of IPPV ↓90d mortality in HFNO - https://t.co/gzKFz8ORxa
FLORALI - 2015 - FM vs HFNO vs NIV in non intubated ARDS - ∅rates of IPPV ↓90d mortality in HFNO - https://t.co/gzKFz8ORxa
FLORALI - 2015 - FM vs HFNO vs NIV in non intubated ARDS - ∅rates of IPPV ↓90d mortality in HFNO - https://t.co/gzKFz8ORxa
RT @ArgaizR: The FLORALI trial might add some indirect evidence of this. BIPAP provides pressure support so; If pt has a high respiratory d…
https://t.co/6FldT2MgRK
RT @ArgaizR: The FLORALI trial might add some indirect evidence of this. BIPAP provides pressure support so; If pt has a high respiratory d…
RT @ArgaizR: The FLORALI trial might add some indirect evidence of this. BIPAP provides pressure support so; If pt has a high respiratory d…
RT @WF_Parker: Also use HFNC to prevent intubation! https://t.co/GZTKEANnJj
RT @WF_Parker: Also use HFNC to prevent intubation! https://t.co/GZTKEANnJj
RT @WF_Parker: Also use HFNC to prevent intubation! https://t.co/GZTKEANnJj
RT @WF_Parker: Also use HFNC to prevent intubation! https://t.co/GZTKEANnJj
https://t.co/n4a2flLKhO
Also use HFNC to prevent intubation! https://t.co/GZTKEANnJj
RT @ArgaizR: The FLORALI trial might add some indirect evidence of this. BIPAP provides pressure support so; If pt has a high respiratory d…
The FLORALI trial might add some indirect evidence of this. BIPAP provides pressure support so; If pt has a high respiratory drive, BIPAP could actually worsen P-SILI. CPAP is not expected to do this. HFNC by reducing dead space can reduce WOB. 10.1056/NEJMoa1503326 (13) https://t.co/P9Rx0L5Fl2
RT @jsenior64: @heiderespinel https://t.co/sw0LilRzOi
@heiderespinel https://t.co/sw0LilRzOi
RT @HollyRistell: Important to keep this and other research in mind at this time! Worse outcomes with NIV than 15L/min NRB High-Flow Oxygen…
RT @HollyRistell: Important to keep this and other research in mind at this time! Worse outcomes with NIV than 15L/min NRB High-Flow Oxygen…
RT @HollyRistell: Important to keep this and other research in mind at this time! Worse outcomes with NIV than 15L/min NRB High-Flow Oxygen…
Important to keep this and other research in mind at this time! Worse outcomes with NIV than 15L/min NRB High-Flow Oxygen through Nasal Cannula in Acute Hypoxemic Respiratory Failure | NEJM https://t.co/nKBx0S6NFM
@FrazerrespPT @mariabuxton2gm1 I agree. I can’t stop thinking about the 3 way Optiflow trial where patients on NIV did worse than on 15L NRBM. I know it was mainly bacterial pneumonia, NIV instead of CPAP & lower PEEPs but many of the principles are not dissimilar. https://t.co/RHeS09v8Fg
@innov8doc @docmartin22 @SiDenning @EMARIANOMD @SickKidsNews The difference in cough aerosol distance is minimal in this study. Additionally, ALL the patients have cough. The entire environment is contaminated. Why would you have us forego a life-saving intervention with a hypothetical risk? https://t.co/ThoWuI6uqb
RT @drdangayach: #chestchat T2: #ARDS EOLIA:https://t.co/cDzrqNrhNO my fav high flow nasal canula https://t.co/ExCh8a4lU7
#chestchat T2: #ARDS EOLIA:https://t.co/cDzrqNrhNO my fav high flow nasal canula https://t.co/ExCh8a4lU7
High-Flow Oxygen through Nasal Cannula in Acute Hypoxemic Respiratory Failure Jean-Pierre Frat, M.D., Arnaud W. Thille, M.D., Ph.D., Alain Mercat, M.D., - ppt download https://t.co/52O8mCvF6H
RT @leejanhau: Good to know some adult data as well. Schibler sharing some data of #HFNC in #ICU #PedsICU #ASMIC2019 #3rdAPIC https://t.co…
RT @leejanhau: Good to know some adult data as well. Schibler sharing some data of #HFNC in #ICU #PedsICU #ASMIC2019 #3rdAPIC https://t.co…
RT @leejanhau: Good to know some adult data as well. Schibler sharing some data of #HFNC in #ICU #PedsICU #ASMIC2019 #3rdAPIC https://t.co…
RT @CriticalCareNew: Treatment with high-flow oxygen, standard oxygen, or noninvasive ventilation did not result in significantly different…
Treatment with high-flow oxygen, standard oxygen, or noninvasive ventilation did not result in significantly different intubation rates #CriticalCare https://t.co/9I1Ph3u5PL
19.A more direct replacement for HFOV also garnered traction when High Flow Nasal Cannula (HFNC) was shown to produce ⬇️ 90d mortality compared to traditional non-invasive positive pressure ventilation. HFNC is used commonly today HFNC Trial (@NEJM 2015): https://t.co/Xyg85YqOM6
@Sam_Pannick It’s probably worse - see https://t.co/LBCUp5zxHS which compared to bilevel ventilation, albeit with fairly low settings of 13/5.
RT @drdangayach: Acute hypoxemix resp failure: https://t.co/54565EvkeP #CCC48 #critcarecontroversies HFNC and NIV: https://t.co/4a2yzLOzf…
RT @drdangayach: Acute hypoxemix resp failure: https://t.co/54565EvkeP #CCC48 #critcarecontroversies HFNC and NIV: https://t.co/4a2yzLOzf…
RT @drdangayach: Acute hypoxemix resp failure: https://t.co/54565EvkeP #CCC48 #critcarecontroversies HFNC and NIV: https://t.co/4a2yzLOzf…
Acute hypoxemix resp failure: https://t.co/54565EvkeP #CCC48 #critcarecontroversies HFNC and NIV: https://t.co/4a2yzLOzf9 Higher Vt seen on pts on NIV/HFNC in pts who failed NIV https://t.co/2a8zkOOOKi https://t.co/Ua9AGuiJkz
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