June 2015 PMID 25999455

CD19-targeted chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia.

Shannon L Maude, David T Teachey, David L Porter, Stephan A Grupp

Mentions

10
Peak: 1 in Aug 2018
across 4 sources since Aug 2018

Extended reach

1,810
potential audience

Total likes

28

Video views

1,809

Mentions per month

Aug 2018 – Jun 2024

Where it's discussed

  • News4 articles
  • Blogs3 articles
  • YouTube2 videos
  • Bluesky1 posts

AI synopsis

What people are saying

The collective discussions reflect cautious optimism, as commenters mention the potential benefits while also emphasizing the need for further research and adjustments, using words like 'hopeful' and 'much to tweak,' which indicate a balanced view of promise and challenge.

AgreementModerate agreement

Posts generally express cautious optimism about the potential of CD19 CAR-T therapy for conditions beyond leukemia, such as multiple sclerosis, showing some support for ongoing research.

InterestModerate interest

Discussions indicate a moderate level of curiosity about the therapy's possibilities, with some posts highlighting its hopeful aspects while acknowledging the need for further investigation.

EngagementModerate engagement

Participants reference specific studies and mention the need for tweaks and more research, reflecting a genuine interest and active engagement.

ImpactModerate impact

The discussions suggest that these developments could influence future treatments, but the overall impact is seen as promising yet preliminary.

Abstract in brief

  • Relapsed and refractory ALL has been hard to treat, but CAR T-cell therapy targeting CD19 has shown promising results with high remission rates.
  • The therapy involves engineering T cells to attack B cells, leading to durable remissions in some patients, though factors like remission duration and T cell persistence need more research.
  • A major challenge with this treatment is cytokine release syndrome (CRS), a side effect caused by T cell activation, which requires careful management and remains an area of ongoing study.]

Top posts

Most liked on X and Bluesky
Marc Veldhoen
@marcveld.bsky.social · Bluesky

CD19-targeted chimeric antigen receptor T cell therapy in two patients with multiple sclerosis CD19 CAR-T cell therapy showed some promise, tested in 2 MS patients. There is much to tweak and investigate, but it is hopeful. www.cell.com/med/ful... 1/2

Jun 15, 2024 · 2 likes · 1 share View post →

All mentions

Marc Veldhoen
@marcveld.bsky.social · Bluesky

CD19-targeted chimeric antigen receptor T cell therapy in two patients with multiple sclerosis CD19 CAR-T cell therapy showed some promise, tested in 2 MS patients. There is much to tweak and investigate, but it is hopeful. www.cell.com/med/ful... 1/2

Jun 15, 2024 · 2 likes · 1 share View post →