Impaired mitochondrial fat oxidation induces adaptive remodeling of muscle metabolism.

Abstract in brief

• Impaired mitochondrial fat oxidation in muscles leads to metabolic changes such as increased carbohydrate use, more circulating fatty acids, and lipid buildup within muscles, which can contribute to insulin resistance.
• When mitochondrial fatty acid oxidation is severely inhibited, muscles adapt by increasing mitochondrial biogenesis, activating peroxisomal fat oxidation, and breaking down amino acids to maintain energy, all coordinated by signaling pathways like AMPK and PGC1α.
• These muscle adaptations help the body resist obesity, demonstrating a complex relationship between fat metabolism, energy regulation, and metabolic health.]