August 2015 PMID 26068424

Direct evidence for GABAergic activity of Withania somnifera on mammalian ionotropic GABAA and GABAρ receptors.

Manuel Candelario, Erika Cuellar, Jorge Mauricio Reyes-Ruiz, Narek Darabedian, Zhou Feimeng, Ricardo Miledi, Amelia Russo-Neustadt, Agenor Limon

Mentions

8
Peak: 1 in Aug 2018
across 4 sources since Aug 2018

Extended reach

155,512
potential audience

Total likes

3,414

Video views

155,370

Mentions per month

Aug 2018 – Jul 2025

Where it's discussed

  • YouTube3 videos
  • Facebook2 posts
  • News2 articles
  • X / Twitter1 posts

AI synopsis

What people are saying

The discussions reflect a moderate level of engagement, focusing on the experimental aspects such as the concentration-dependent ion currents elicited by WS extract and their blockade by bicuculline, which highlight interest in the mechanisms rather than broad conclusions. Language is neutral and technical, suggesting a appreciation for the scientific process without strong emotional or projected impact.

AgreementModerate agreement

Comments generally acknowledge the experimental data, reflecting moderate agreement with the findings, such as the mention of GABAA receptor activation and the role of WS extract in modulating ion channels.

InterestModerate interest

Discussions show interest by referencing specific experimental details like concentration levels and antagonist blocking, indicating engagement with the scientific details, but do not express high enthusiasm.

EngagementModerate engagement

Posts cite particular results and methodology, such as the use of microtransplanted oocytes and the effects of bicuculline, demonstrating a decent level of technical engagement.

ImpactNeutral impact

The discussions suggest some appreciation of the research's significance, but overall tone remains cautious or observational rather than emphasizing sweeping implications.

Abstract in brief

  • Withania somnifera (WS) is traditionally used in Ayurvedic medicine for various mental health issues and this study supports its effectiveness in enhancing cognitive function via GABAergic signaling.
  • The study evaluated the effects of aqueous WS root extract and its components (withaferin A and withanolide A) on GABAA receptors, using rat brain receptors transplanted into oocytes for testing.
  • Results indicated that the WS extract activates GABAA channels but with less effectiveness than GABA, while it showed strong agonistic activity on GABAρ1 receptors, suggesting different mechanisms for its action that do not rely directly on GABA.

Top posts

Most liked on X and Bluesky
bioMioSoftware
@bioMioSoftware · X

@HealthyFellow @_atanas_ @_INPST @HerbalGram @deNutrients @BetterSleepOrg @SleepNews https://t.co/DA5jMHWro6 "Concentration-dependent inward ion currents were elicited by aqWS in microtransplanted oocytes with an EC50 equivalent to 4.7 mg/mL and a Hill coefficient (nH) of 1.6. The GABAA receptor antagonist bicuculline blocked these currents. "

Nov 5, 2020 · 2 likes · 102 followers View post →

All mentions

bioMioSoftware
@bioMioSoftware · X

@HealthyFellow @_atanas_ @_INPST @HerbalGram @deNutrients @BetterSleepOrg @SleepNews https://t.co/DA5jMHWro6 "Concentration-dependent inward ion currents were elicited by aqWS in microtransplanted oocytes with an EC50 equivalent to 4.7 mg/mL and a Hill coefficient (nH) of 1.6. The GABAA receptor antagonist bicuculline blocked these currents. "

Nov 5, 2020 · 2 likes · 102 followers View post →
Candelario2015 Journal of Ethnopharmacology | PDF ...
News

the online version at http://dx.doi.org/10.1016/j.jep.2015.05.058. ... subunits. Proc. R. Soc. Lond. 263, 273–282. ... 55 compounds. Although the neurotransmitter ...

Dec 25, 2025 View →
Naturopathy Strategies for Alzheimer's Disease | PDF | Acetylcholine ...
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Decreased acetylcholine release is correlated to memory col., 2015, 171, 264-272. http://dx.doi.org/10.1016/j.jep.2015.05.058 PMID: 26068424. Current ...

Dec 25, 2025 View →
ANGST OG ASHWAGANDHA Hvis du har angst eller PTSD, kan du ...
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Nu skal jeg ud og købe din bog om overgangsalder men er ashwagandha en del af dem man bør tage. 6 mos. 1. Milena Penkowa.

Jul 4, 2025 View →
Supplement Ingredient Review: Withania somnifera ... - Facebook
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... jep.2015.05.058 3. Gupta M and Kaur G (2018) ... 10.1016/j.expneurol.2018.08.008 5 ... doi: 10.1016/j. jep.2015.05.058 3. Gupta M ...

Aug 28, 2018 View →