J Urol November 2015 PMID 26119670

PnPP-19, a Synthetic and Nontoxic Peptide Designed from a Phoneutria nigriventer Toxin, Potentiates Erectile Function via NO/cGMP.

Carolina Nunes Silva, Kenia Pedrosa Nunes, Fernanda Silva Torres, Juliana Silva Cassoli, Daniel Moreira Santos, Flávia De Marco Almeida, Alessandra Matavel, Jader Santos Cruz, Arthur Santos-Miranda, Allancer Divino C Nunes, Carlos Henrique Castro, Ricardo Andrés Machado de Ávila, Carlos Chávez-Olórtegui, Stephanie Stransky Láuar, Liza Felicori

Mentions

9
Peak: 5 in Jan 2020
across 3 sources since Jan 2020

Extended reach

72,560
potential audience

Total likes

3,206

Video views

67,229

Mentions per month

Jan 2020 – Oct 2025

Where it's discussed

  • X / Twitter5 posts
  • YouTube2 videos
  • News2 articles

AI synopsis

What people are saying

The overall discussions are characterized by dismissive remarks and a somewhat humorous or trivial tone, mostly centered around setting up serpentariums and extracting venom, rather than engaging with the scientific articles’ implications. Words like 'resistenciaçífica' and phrases like 'montar um serpentário, extrair veneno e ficar rico' reflect curiosity mixed with casual or ironic attitude, which diminishes perceived seriousness and impact of the research.

AgreementStrong disagreement

Most discussions express skepticism or dismissiveness regarding the technical details and significance of the study, with some seemingly mocking or trivializing the research.

InterestNeutral interest

The conversations show limited interest in the scientific findings, focusing instead on unrelated topics like setting up serpentariums and extracting venom, which suggests distraction or disconnection from the research’s importance.

EngagementLow engagement

Many posts dismiss or ignore the scientific content, engaging superficially rather than critically analyzing or discussing the implications of the publication.

ImpactLow impact

The general tone appears dismissive or trivial, indicating the discussion has little to no influence on advancing understanding or application of the research findings.

Abstract in brief

  • PnPP19 is a synthetic, non-toxic peptide derived from a toxin in Phoneutria nigriventer that enhances erectile function through the nitric oxide (NO) and cGMP pathway, without affecting sodium channels or causing heart toxicity.
  • Experiments showed PnPP19 successfully increases erectile responses in rats both in vivo and ex vivo, especially at certain frequencies, and raises cGMP levels—a process that can be blocked by specific inhibitors, confirming its mechanism involving nitric oxide synthase.
  • The peptide demonstrated low immunogenicity and no significant tissue toxicity in mice, making it a promising candidate for developing new treatments for erectile dysfunction.]

Top posts

Most liked on X and Bluesky
Jaime Culebras
@Jaime_Culebras · X

Y aquí por si alguien tiene curiosidad de leer sobre estos estudios de Phoneutria: https://t.co/pT4suaguXR https://t.co/Kzz9jKMctp https://t.co/NsP5QudhE6 https://t.co/pEwgwNDfA2 https://t.co/cXA4VADQHi

Aug 9, 2023 · 3,912 followers View post →
Marcus
@marcusrg · X

Só para os fortes! ResistênciaCientífica #BiólogoHenrique # Serpentário (AULA 4) Montar Um Serpentário, Extrair Veneno e Ficar Rico! Será? https://t.co/V8UfEY0E2k https://t.co/cnxxcGDQp6

Jan 14, 2020 · 590 followers View post →
Marcus
@marcusrg · X

Só para os fortes! ResistênciaCientífica #BiólogoHenrique # Serpentário (AULA 4) Montar Um Serpentário, Extrair Veneno e Ficar Rico! Será? https://t.co/V8UfEY0E2k https://t.co/V8UfEY0E2k

Jan 14, 2020 · 590 followers View post →
Resistência Científica
@ResistCiencia · X

Só para os fortes! ResistênciaCientífica #BiólogoHenrique # Serpentário (AULA 4) Montar Um Serpentário, Extrair Veneno e Ficar Rico! Será? https://t.co/RRWg3Omv3h https://t.co/1F7CZcWJMo

Jan 14, 2020 · 134 followers View post →

All mentions

Jaime Culebras
@Jaime_Culebras · X

Y aquí por si alguien tiene curiosidad de leer sobre estos estudios de Phoneutria: https://t.co/pT4suaguXR https://t.co/Kzz9jKMctp https://t.co/NsP5QudhE6 https://t.co/pEwgwNDfA2 https://t.co/cXA4VADQHi

Aug 9, 2023 · 3,912 followers View post →
Resistência Científica
@ResistCiencia · X

Só para os fortes! ResistênciaCientífica #BiólogoHenrique # Serpentário (AULA 4) Montar Um Serpentário, Extrair Veneno e Ficar Rico! Será? https://t.co/RRWg3Omv3h https://t.co/1F7CZcWJMo

Jan 14, 2020 · 134 followers View post →
CientoNauta
@CientoNauta · X

Só para os fortes! ResistênciaCientífica #BiólogoHenrique # Serpentário (AULA 4) Montar Um Serpentário, Extrair Veneno e Ficar Rico! Será? https://t.co/aPz5W5GQLN https://t.co/p6UgnkdrEt

Jan 14, 2020 · 86 followers View post →
Marcus
@marcusrg · X

Só para os fortes! ResistênciaCientífica #BiólogoHenrique # Serpentário (AULA 4) Montar Um Serpentário, Extrair Veneno e Ficar Rico! Será? https://t.co/V8UfEY0E2k https://t.co/cnxxcGDQp6

Jan 14, 2020 · 590 followers View post →
Marcus
@marcusrg · X

Só para os fortes! ResistênciaCientífica #BiólogoHenrique # Serpentário (AULA 4) Montar Um Serpentário, Extrair Veneno e Ficar Rico! Será? https://t.co/V8UfEY0E2k https://t.co/V8UfEY0E2k

Jan 14, 2020 · 590 followers View post →
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