Curr Pharm Biotechnol March 2016 PMID 26278529

Inhibition of Melanogenesis by Yeast Extracts from Cultivations of Recombinant Pichia pastoris Catalyzing ortho-Hydroxylation of Flavonoids.

Te-sheng Chang, Yi-Hsuan Tsai

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Peak: 9 in Jul 2024

across 2 sources since Dec 2020

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9,709

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Dec 2020 – Jul 2024

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AI synopsis

What people are saying

The discussions reflect a generally positive outlook on the article's findings, with users mentioning the potential for skin-lightening agents and skin protection, exemplified by phrases like 'promising new approach' and 'important step forward'. The tone and choice of technical terms like 'melanin synthesis' and 'Nrf2 signaling' show engagement with scientific details, emphasizing the perceived importance of the research's implications.

AgreementModerate agreement

Most discussions acknowledge the significance of the research, especially the potential for new skin-lightening agents and protective skin effects, with phrases like 'promising', 'exciting', and 'innovative'.

InterestModerate interest

Posts show moderate interest, frequently referencing specific flavonoids like apigenin and naringenin and their skin-related effects, indicating curiosity in the detailed mechanisms and applications.

EngagementModerate engagement

Comments delve into aspects such as molecular pathways, effects on keratinocytes, and implications for skincare, demonstrating a decent level of engagement and analysis.

ImpactModerate impact

Several posts highlight the potential impact on dermatology, cosmetic science, and skin health, suggesting the research could influence future treatments or products.

Abstract in brief

The study investigated how yeast extracts from genetically modified Pichia pastoris can change flavonoids (plant compounds) and potentially inhibit melanin production in skin cells.
Researchers identified that five specific flavonoids (apigenin, naringenin, liquiritigenin, daidzein, genistein) could be transformed by the yeast, and extracts from these transformations showed skin-lightening effects, especially the one from genistein.
This research highlights a new way to produce skin-whitening agents using genetically engineered yeast that modifies flavonoids, focusing on their ability to inhibit melanin synthesis in skin cells.]

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lavicub

@lavicub · X

12. **Enhancement of UVB-induced apoptosis by apigenin in human keratinocytes and organotypic keratinocyte cultures** - [Study Link](https://t.co/ZWyjcSYGtY).