Acta Crystallogr D Biol Crystallogr September 2015 PMID 26327377

Structural insights into conformational switching in the copper metalloregulator CsoR from Streptomyces lividans.

Tatiana V Porto, Michael A Hough, Jonathan A R Worrall

Mentions

3
Peak: 2 in Jul 2016
across 2 sources since Jul 2016

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Jul 2016 – Mar 2023

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The discussion exemplifies a moderate positive attitude by recounting a personal connection to the research and scientific facilities, such as the Diamond Light Source, emphasizing the importance of the publication to individual scientific journeys. The tone is nostalgic and appreciative, sparking a sense of relevance and achievement without extensive technical analysis.

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Abstract in brief

  • The study presents a new X-ray crystal structure of the CsoR copper metalloregulator from Streptomyces lividans, revealing how it changes shape (conformational switching) when binding copper(I) ions.
  • The switching mechanism involves a concertina effect at the end of specific helices in the protein, causing key residues like Cys104 to move into a position where they can bind copper, leading to structural rearrangements.
  • This conformational change also alters the electrostatic surface of the protein, particularly on the DNA-binding face, which explains how copper binding causes CsoR to disassemble from DNA, triggering a genetic response to copper stress.]

Top posts

Most liked on X and Bluesky
Dr Tatiana Porto
@drtatianaporto5 · X

Inside the amazing Diamond Light Source on a training day as part of my PhD in 2013. My protein crystals were measured there,including the star of my very first scientific paper Structural insights into conformational switching in the copper metalloregulator CsoR from S.lividans. https://t.co/mg4Staanur

Mar 8, 2023 · 2 likes · 1,108 followers View post →

All mentions

Dr Tatiana Porto
@drtatianaporto5 · X

Inside the amazing Diamond Light Source on a training day as part of my PhD in 2013. My protein crystals were measured there,including the star of my very first scientific paper Structural insights into conformational switching in the copper metalloregulator CsoR from S.lividans. https://t.co/mg4Staanur

Mar 8, 2023 · 2 likes · 1,108 followers View post →