Biogerontology June 2016 PMID 26349924

Skeletal muscle cells possess a 'memory' of acute early life TNF-α exposure: role of epigenetic adaptation.

Adam P Sharples, Ioanna Polydorou, David C Hughes, Daniel J Owens, Thomas M Hughes, Claire E Stewart

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Peak: 6 in Jun 2019

across 4 sources since Jun 2019

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What people are saying

The discussions highlight specific findings like demethylation's role in muscle differentiation, as seen in the mention of 'demethylation of myogenic genes' and observations related to myoD, reflecting a focus on molecular mechanisms and scientific relevance, with a tone suggesting curiosity and scientific interest.

AgreementModerate agreement

The posts show a general agreement with the importance of epigenetic changes in muscle cells, as they reference the significance of demethylation in muscle differentiation.

InterestModerate interest

There is moderate interest, with discussions focusing on specific mechanisms and observations, such as demethylation of myogenic genes in muscle differentiation.

EngagementModerate engagement

The posts demonstrate some engagement by connecting the study to known processes and personal observations, suggesting a thoughtful reflection rather than casual mentions.

ImpactNeutral impact

The comments indicate some recognition of the impact of epigenetic mechanisms on muscle health, but lack strong claims about broad impacts.

Abstract in brief

Skeletal muscle cells have a form of "memory" that records early life stress and influences muscle decline with age, such as in conditions like fetal malnutrition, obesity, or cancer.
The cytokine TNF-alpha, which is often elevated in muscle-wasting diseases like sarcopenia and cachexia, impairs muscle regeneration and reduces muscle strength through mechanisms involving epigenetic regulation, specifically via the SIRT1 enzyme.
The research suggests that exposure to TNF can lead to lasting epigenetic changes in muscle cells, influencing their ability to grow and repair, which is studied using muscle precursor cells (myoblasts) that are exposed to TNF and then observed over multiple cell divisions to understand muscle memory and loss.]

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